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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Yol054w. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 14 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
EDE1
  • cellular bud tip
  • cellular bud neck
  • actin cortical patch
  • endocytosis
  • ubiquitin binding
  • GAC1
  • protein phosphatase type 1 complex
  • negative regulation of transcription from RNA polymerase II promoter
  • mitotic cell cycle spindle assembly checkpoint
  • response to heat
  • glycogen metabolic process
  • meiosis
  • heat shock protein binding
  • structural molecule activity
  • protein phosphatase type 1 regulator activity
  • HHF1, HHF2
  • nucleus
  • nucleoplasm part
  • nuclear nucleosome
  • chromosome
  • replication fork protection complex
  • chromatin remodeling complex
  • nucleosome
  • histone acetyltransferase complex
  • nucleoplasm
  • histone H3-K79 methylation
  • DNA repair
  • negative regulation of transcription
  • chromatin assembly or disassembly
  • positive regulation of transcription
  • nucleosome assembly
  • DNA binding
  • HTA1
  • nuclear nucleosome
  • DNA repair
  • chromatin assembly or disassembly
  • DNA binding
  • HTA2
  • nuclear nucleosome
  • DNA repair
  • chromatin assembly or disassembly
  • DNA binding
  • HTB1
  • nuclear nucleosome
  • chromatin assembly or disassembly
  • postreplication repair
  • DNA binding
  • HTB2
  • nuclear nucleosome
  • chromatin assembly or disassembly
  • DNA binding
  • KNS1
  • cellular_component
  • protein amino acid phosphorylation
  • protein tyrosine kinase activity
  • protein serine/threonine kinase activity
  • MAM33
  • mitochondrial matrix
  • mitochondrion
  • response to drug
  • aerobic respiration
  • molecular_function
  • NOB1
  • nucleus
  • preribosome
  • maturation of SSU-rRNA
  • ribosomal small subunit biogenesis
  • ribosome biogenesis
  • proteasome assembly
  • RNA binding
  • protein binding
  • POB3
  • nucleus
  • FACT complex
  • nuclear chromatin
  • alpha DNA polymerase:primase complex
  • chromatin remodeling
  • DNA-dependent DNA replication
  • chromatin assembly or disassembly
  • transcription initiation from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • chromatin binding
  • PSH1
  • nucleus
  • RNA elongation from RNA polymerase II promoter
  • molecular_function
  • SPT16
  • FACT complex
  • nuclear chromatin
  • alpha DNA polymerase:primase complex
  • transcription elongation factor complex
  • transcription initiation from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • transcription elongation regulator activity
  • RNA polymerase II transcription elongation factor activity
  • SYP1
  • cellular bud tip
  • cellular bud neck
  • mating projection base
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein-DNA complex 1.1192E-11 14 57 7 6292
    nuclear nucleosome 1.9164E-11 14 12 5 6292
    nucleosome 1.9164E-11 14 12 5 6292
    nuclear chromatin 6.7898E-11 14 73 7 6292
    chromatin 9.982E-11 14 77 7 6292
    nuclear chromosome part 5.8858E-8 14 190 7 6292
    nuclear chromosome 2.0689E-7 14 228 7 6292
    chromosomal part 2.6981E-7 14 237 7 6292
    chromosome 7.2642E-7 14 274 7 6292
    FACT complex 4.5979E-6 14 2 2 6292
    nuclear replication fork 9.7792E-6 14 20 3 6292
    replication fork 9.5672E-5 14 42 3 6292
    alpha DNA polymerase:primase complex 9.5944E-5 14 7 2 6292
    non-membrane-bounded organelle 3.6012E-4 14 959 8 6292
    intracellular non-membrane-bounded organelle 3.6012E-4 14 959 8 6292
    replisome 6.8931E-4 14 18 2 6292
    nuclear replisome 6.8931E-4 14 18 2 6292
    transcription elongation factor complex 1.1326E-3 14 23 2 6292
    macromolecular complex 2.8523E-3 14 1635 9 6292
    replication fork protection complex 4.4455E-3 14 2 1 6292
    nuclear part 5.4526E-3 14 1103 7 6292
    cellular bud tip 6.8428E-3 14 57 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    chromatin assembly or disassembly 5.4927E-11 14 35 6 6292
    chromatin organization 2.5351E-6 14 203 6 6292
    RNA elongation from RNA polymerase II promoter 7.6464E-5 14 39 3 6292
    RNA elongation 1.1779E-4 14 45 3 6292
    cellular component organization 3.5382E-4 14 1582 10 6292
    DNA repair 6.6151E-4 14 192 4 6292
    chromosome organization 7.4315E-4 14 555 6 6292
    nucleic acid metabolic process 9.44E-4 14 1415 9 6292
    response to DNA damage stimulus 1.4349E-3 14 236 4 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.0587E-3 14 1566 9 6292
    histone H3-K79 methylation 2.225E-3 14 1 1 6292
    macromolecular complex assembly 2.7315E-3 14 281 4 6292
    cellular response to stress 3.0647E-3 14 290 4 6292
    response to stress 3.3093E-3 14 497 5 6292
    response to stimulus 4.0359E-3 14 766 6 6292
    protein complex biogenesis 4.3711E-3 14 155 3 6292
    protein complex assembly 4.3711E-3 14 155 3 6292
    histone lysine methylation 4.4455E-3 14 2 1 6292
    transcription initiation from RNA polymerase II promoter 4.694E-3 14 47 2 6292
    cellular nitrogen compound metabolic process 5.1472E-3 14 1770 9 6292
    transcription from RNA polymerase II promoter 5.1608E-3 14 335 4 6292
    transcription 5.2299E-3 14 552 5 6292
    nitrogen compound metabolic process 5.6129E-3 14 1791 9 6292
    organelle organization 6.1726E-3 14 1127 7 6292
    macromolecular complex subunit organization 6.4746E-3 14 357 4 6292
    DNA metabolic process 6.7131E-3 14 585 5 6292
    transcription initiation 7.0781E-3 14 58 2 6292
    cellular response to stimulus 7.9988E-3 14 379 4 6292
    cellular macromolecule metabolic process 8.0823E-3 14 2285 10 6292
    cellular component assembly 8.4529E-3 14 385 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA binding 1.5869E-4 14 256 5 6292
    binding 4.6837E-4 14 1294 9 6292
    nucleic acid binding 1.9573E-3 14 666 6 6292
    protein tyrosine kinase activity 2.225E-3 14 1 1 6292
    heat shock protein binding 6.6614E-3 14 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle