YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Sir4. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 6 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BLM10
  • nucleus
  • proteasome core complex
  • proteasome complex
  • protein catabolic process
  • proteasome assembly
  • proteasome activator activity
  • SEC53
  • cytosol
  • protein targeting to ER
  • phosphomannomutase activity
  • SIR2
  • nuclear telomeric heterochromatin
  • RENT complex
  • nucleolus
  • chromatin silencing complex
  • nuclear telomere cap complex
  • chromatin silencing at rDNA
  • loss of chromatin silencing involved in replicative cell aging
  • chromatin assembly or disassembly
  • negative regulation of DNA replication
  • double-strand break repair via nonhomologous end joining
  • chromatin silencing at silent mating-type cassette
  • replicative cell aging
  • chromatin silencing at telomere
  • chronological cell aging
  • NAD-dependent histone deacetylase activity (H3-K9 specific)
  • NAD-dependent histone deacetylase activity (H4-K16 specific)
  • NAD-dependent histone deacetylase activity (H3-K14 specific)
  • NAD-dependent histone deacetylase activity
  • SIR3
  • nuclear telomeric heterochromatin
  • mitochondrion
  • nucleolus
  • chromatin silencing complex
  • nuclear telomere cap complex
  • loss of chromatin silencing involved in replicative cell aging
  • chromatin silencing
  • double-strand break repair via nonhomologous end joining
  • structural constituent of chromatin
  • histone binding
  • SIR4
  • nuclear telomeric heterochromatin
  • chromatin silencing complex
  • nuclear telomere cap complex
  • loss of chromatin silencing involved in replicative cell aging
  • telomere maintenance
  • chromatin silencing
  • double-strand break repair via nonhomologous end joining
  • structural constituent of chromatin
  • histone binding
  • SRP1
  • nucleus
  • cytoplasm
  • nucleocytoplasmic transport
  • protein transmembrane transporter activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear telomeric heterochromatin 1.6845E-8 6 7 3 6292
    telomeric heterochromatin 1.6845E-8 6 7 3 6292
    nuclear heterochromatin 1.6845E-8 6 7 3 6292
    heterochromatin 1.6845E-8 6 7 3 6292
    chromatin silencing complex 4.0399E-8 6 9 3 6292
    telomere cap complex 7.9298E-8 6 11 3 6292
    nuclear telomere cap complex 7.9298E-8 6 11 3 6292
    nuclear chromosome, telomeric region 8.4748E-7 6 23 3 6292
    chromosome, telomeric region 1.3977E-6 6 27 3 6292
    protein-DNA complex 1.3832E-5 6 57 3 6292
    nuclear chromatin 2.9233E-5 6 73 3 6292
    chromatin 3.4332E-5 6 77 3 6292
    chromatin remodeling complex 7.3032E-5 6 99 3 6292
    nuclear chromosome part 5.0688E-4 6 190 3 6292
    nuclear chromosome 8.6609E-4 6 228 3 6292
    chromosomal part 9.7004E-4 6 237 3 6292
    chromosome 1.4813E-3 6 274 3 6292
    RENT complex 3.8098E-3 6 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    loss of chromatin silencing involved in replicative cell aging 4.0399E-8 6 9 3 6292
    progressive alteration of chromatin involved in replicative cell aging 5.7692E-8 6 10 3 6292
    loss of chromatin silencing 5.7692E-8 6 10 3 6292
    progressive alteration of chromatin involved in cell aging 7.9298E-8 6 11 3 6292
    positive regulation of gene expression, epigenetic 7.9298E-8 6 11 3 6292
    regulation of gene silencing 7.9298E-8 6 11 3 6292
    negative regulation of gene silencing 7.9298E-8 6 11 3 6292
    regulation of chromatin silencing 7.9298E-8 6 11 3 6292
    negative regulation of chromatin silencing 7.9298E-8 6 11 3 6292
    double-strand break repair via nonhomologous end joining 1.0998E-6 6 25 3 6292
    non-recombinational repair 2.8523E-6 6 34 3 6292
    replicative cell aging 4.0152E-6 6 38 3 6292
    cell aging 8.7346E-6 6 49 3 6292
    aging 9.8657E-6 6 51 3 6292
    double-strand break repair 1.3832E-5 6 57 3 6292
    negative regulation of gene expression, epigenetic 7.5263E-5 6 100 3 6292
    gene silencing 7.5263E-5 6 100 3 6292
    regulation of gene expression, epigenetic 7.5263E-5 6 100 3 6292
    chromatin silencing 7.5263E-5 6 100 3 6292
    positive regulation of transcription, DNA-dependent 8.2226E-5 6 103 3 6292
    positive regulation of RNA metabolic process 9.2151E-5 6 107 3 6292
    positive regulation of transcription 1.0563E-4 6 112 3 6292
    positive regulation of gene expression 1.0563E-4 6 112 3 6292
    positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.2343E-4 6 118 3 6292
    positive regulation of nitrogen compound metabolic process 1.2343E-4 6 118 3 6292
    positive regulation of macromolecule biosynthetic process 1.2343E-4 6 118 3 6292
    positive regulation of biosynthetic process 1.3303E-4 6 121 3 6292
    positive regulation of cellular biosynthetic process 1.3303E-4 6 121 3 6292
    positive regulation of macromolecule metabolic process 1.5008E-4 6 126 3 6292
    positive regulation of metabolic process 1.6098E-4 6 129 3 6292
    positive regulation of cellular metabolic process 1.6098E-4 6 129 3 6292
    positive regulation of cellular process 1.8838E-4 6 136 3 6292
    positive regulation of biological process 1.9253E-4 6 137 3 6292
    negative regulation of transcription, DNA-dependent 2.8847E-4 6 157 3 6292
    negative regulation of RNA metabolic process 2.9395E-4 6 158 3 6292
    negative regulation of transcription 3.2824E-4 6 164 3 6292
    negative regulation of gene expression 3.2824E-4 6 164 3 6292
    chromatin modification 3.5249E-4 6 168 3 6292
    negative regulation of macromolecule biosynthetic process 3.9768E-4 6 175 3 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.3217E-4 6 180 3 6292
    negative regulation of nitrogen compound metabolic process 4.3217E-4 6 180 3 6292
    negative regulation of biosynthetic process 4.9905E-4 6 189 3 6292
    negative regulation of cellular biosynthetic process 4.9905E-4 6 189 3 6292
    DNA repair 5.2276E-4 6 192 3 6292
    negative regulation of macromolecule metabolic process 5.2276E-4 6 192 3 6292
    chromatin organization 6.159E-4 6 203 3 6292
    negative regulation of cellular metabolic process 6.7096E-4 6 209 3 6292
    negative regulation of metabolic process 6.8043E-4 6 210 3 6292
    response to DNA damage stimulus 9.5812E-4 6 236 3 6292
    negative regulation of cellular process 1.1339E-3 6 250 3 6292
    negative regulation of biological process 1.1741E-3 6 253 3 6292
    cellular response to stress 1.747E-3 6 290 3 6292
    developmental process 2.5619E-3 6 331 3 6292
    regulation of transcription, DNA-dependent 3.2113E-3 6 358 3 6292
    regulation of RNA metabolic process 3.3419E-3 6 363 3 6292
    cellular response to stimulus 3.7823E-3 6 379 3 6292
    regulation of transcription 3.9271E-3 6 384 3 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.9029E-3 6 415 3 6292
    regulation of nitrogen compound metabolic process 4.9367E-3 6 416 3 6292
    proteasome assembly 5.7102E-3 6 6 1 6292
    regulation of gene expression 5.9803E-3 6 445 3 6292
    regulation of macromolecule biosynthetic process 6.4094E-3 6 456 3 6292
    regulation of cellular biosynthetic process 7.0671E-3 6 472 3 6292
    regulation of biosynthetic process 7.1095E-3 6 473 3 6292
    regulation of macromolecule metabolic process 7.7652E-3 6 488 3 6292
    response to stress 8.1759E-3 6 497 3 6292
    transcription, DNA-dependent 8.4571E-3 6 503 3 6292
    negative regulation of DNA replication 8.5551E-3 6 9 1 6292
    RNA biosynthetic process 8.6959E-3 6 508 3 6292
    regulation of primary metabolic process 8.9879E-3 6 514 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of chromatin 7.579E-7 6 2 2 6292
    histone binding 6.8619E-5 6 14 2 6292
    phosphomannomutase activity 9.5359E-4 6 1 1 6292
    histone deacetylase activity (H3-K14 specific) 9.5359E-4 6 1 1 6292
    histone deacetylase activity (H3-K9 specific) 9.5359E-4 6 1 1 6292
    NAD-dependent histone deacetylase activity (H3-K9 specific) 9.5359E-4 6 1 1 6292
    NAD-dependent histone deacetylase activity (H3-K14 specific) 9.5359E-4 6 1 1 6292
    NAD-dependent histone deacetylase activity (H4-K16 specific) 9.5359E-4 6 1 1 6292
    proteasome activator activity 1.9064E-3 6 2 1 6292
    proteasome regulator activity 1.9064E-3 6 2 1 6292
    intramolecular transferase activity, phosphotransferases 6.6592E-3 6 7 1 6292
    protein transmembrane transporter activity 8.5551E-3 6 9 1 6292
    macromolecule transmembrane transporter activity 8.5551E-3 6 9 1 6292
    NAD-dependent protein deacetylase activity 8.5551E-3 6 9 1 6292
    NAD-dependent histone deacetylase activity 8.5551E-3 6 9 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle