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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Rad26. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 22 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ACH1
  • mitochondrion
  • cytosol
  • acetate metabolic process
  • acetyl-CoA metabolic process
  • acetyl-CoA hydrolase activity
  • ACO1
  • mitochondrial matrix
  • mitochondrion
  • cytosol
  • mitochondrial nucleoid
  • glutamate biosynthetic process
  • response to drug
  • citrate metabolic process
  • propionate metabolic process
  • tricarboxylic acid cycle
  • mitochondrial genome maintenance
  • aconitate hydratase activity
  • ADH4
  • mitochondrion
  • fermentation
  • NADH oxidation
  • alcohol dehydrogenase activity, zinc-dependent
  • ADH6
  • soluble fraction
  • cellular aldehyde metabolic process
  • alcohol metabolic process
  • alcohol dehydrogenase (NADP+) activity
  • BIO3
  • cytoplasm
  • biotin biosynthetic process
  • adenosylmethionine-8-amino-7-oxononanoate transaminase activity
  • CDC33
  • nucleus
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • translational initiation
  • translation initiation factor activity
  • ECM10
  • mitochondrion
  • mitochondrial nucleoid
  • protein targeting to mitochondrion
  • protein refolding
  • molecular_function
  • ERG20
  • cytosol
  • ergosterol biosynthetic process
  • isoprenoid biosynthetic process
  • farnesyl diphosphate biosynthetic process
  • geranyltranstransferase activity
  • dimethylallyltranstransferase activity
  • GDI1
  • membrane fraction
  • soluble fraction
  • vesicle-mediated transport
  • Rab GDP-dissociation inhibitor activity
  • MAM33
  • mitochondrial matrix
  • mitochondrion
  • response to drug
  • aerobic respiration
  • molecular_function
  • MDH1
  • mitochondrial matrix
  • mitochondrion
  • malate metabolic process
  • tricarboxylic acid cycle
  • L-malate dehydrogenase activity
  • PTC7
  • mitochondrion
  • biological_process
  • QCR2
  • mitochondrion
  • mitochondrial respiratory chain complex III
  • mitochondrial electron transport, ubiquinol to cytochrome c
  • aerobic respiration
  • ubiquinol-cytochrome-c reductase activity
  • RAD26
  • nucleus
  • cytoplasm
  • transcription-coupled nucleotide-excision repair
  • nucleotide-excision repair
  • DNA-dependent ATPase activity
  • RAD3
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
  • DNA helicase activity
  • general RNA polymerase II transcription factor activity
  • RHR2
  • nucleus
  • cytoplasm
  • response to drug
  • response to osmotic stress
  • glycerol biosynthetic process
  • glycerol-1-phosphatase activity
  • SEC53
  • cytosol
  • protein targeting to ER
  • phosphomannomutase activity
  • TEF4
  • mitochondrion
  • ribosome
  • eukaryotic translation elongation factor 1 complex
  • translational elongation
  • translation elongation factor activity
  • TFP1
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
  • protein metabolic process
  • vacuolar acidification
  • intron homing
  • proton-transporting ATPase activity, rotational mechanism
  • endodeoxyribonuclease activity
  • TIF1, TIF2
  • plasma membrane enriched fraction
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • regulation of translation
  • translational initiation
  • regulation of translational initiation
  • translation
  • nucleotide binding
  • nucleic acid binding
  • translation initiation factor activity
  • ATP binding
  • RNA binding
  • ATP-dependent helicase activity
  • helicase activity
  • ATP-dependent RNA helicase activity
  • hydrolase activity
  • TMA29
  • nucleus
  • cytoplasm
  • ribosome
  • metabolic process
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
  • YSP2
  • mitochondrion
  • apoptosis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    eukaryotic translation initiation factor 4F complex 6.9734E-5 22 4 2 6292
    cytoplasmic part 1.5883E-3 22 2482 16 6292
    mitochondrion 2.5812E-3 22 1125 10 6292
    mitochondrial matrix 2.9167E-3 22 176 4 6292
    mitochondrial lumen 2.9167E-3 22 176 4 6292
    cytoplasm 2.9299E-3 22 3552 19 6292
    plasma membrane enriched fraction 3.4965E-3 22 1 1 6292
    nucleoid 3.6053E-3 22 26 2 6292
    mitochondrial nucleoid 3.6053E-3 22 26 2 6292
    cell fraction 9.7514E-3 22 129 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    energy derivation by oxidation of organic compounds 8.6982E-6 22 149 6 6292
    generation of precursor metabolites and energy 4.0435E-5 22 195 6 6292
    acetyl-CoA metabolic process 4.0707E-5 22 20 3 6292
    cofactor metabolic process 1.5476E-4 22 154 5 6292
    aerobic respiration 1.7186E-4 22 83 4 6292
    cellular respiration 3.1378E-4 22 97 4 6292
    coenzyme metabolic process 7.0557E-4 22 120 4 6292
    tricarboxylic acid cycle 1.1922E-3 22 15 2 6292
    acetyl-CoA catabolic process 1.1922E-3 22 15 2 6292
    coenzyme catabolic process 2.1346E-3 22 20 2 6292
    fermentation 2.1346E-3 22 20 2 6292
    metabolic process 2.2504E-3 22 3157 18 6292
    cofactor catabolic process 2.5843E-3 22 22 2 6292
    small molecule metabolic process 2.9513E-3 22 760 8 6292
    cellular metabolic process 5.2302E-3 22 3033 17 6292
    transcription-coupled nucleotide-excision repair 6.9813E-3 22 2 1 6292
    farnesyl diphosphate biosynthetic process 6.9813E-3 22 2 1 6292
    farnesyl diphosphate metabolic process 6.9813E-3 22 2 1 6292
    nucleotide-excision repair 7.6032E-3 22 38 2 6292
    translational initiation 9.2338E-3 22 42 2 6292
    response to drug 9.5462E-3 22 128 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation factor activity, nucleic acid binding 4.4788E-4 22 44 3 6292
    catalytic activity 1.1562E-3 22 2150 15 6292
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.9696E-3 22 73 3 6292
    oxidoreductase activity 2.4117E-3 22 281 5 6292
    oxidoreductase activity, acting on CH-OH group of donors 2.6534E-3 22 81 3 6292
    adenosylmethionine-8-amino-7-oxononanoate transaminase activity 3.4965E-3 22 1 1 6292
    geranyltranstransferase activity 3.4965E-3 22 1 1 6292
    phosphomannomutase activity 3.4965E-3 22 1 1 6292
    Rab GDP-dissociation inhibitor activity 3.4965E-3 22 1 1 6292
    dimethylallyltranstransferase activity 3.4965E-3 22 1 1 6292
    acetyl-CoA hydrolase activity 3.4965E-3 22 1 1 6292
    translation initiation factor activity 3.8855E-3 22 27 2 6292
    alcohol dehydrogenase activity, zinc-dependent 6.9813E-3 22 2 1 6292
    GDP-dissociation inhibitor activity 6.9813E-3 22 2 1 6292
    aconitate hydratase activity 6.9813E-3 22 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle