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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Yck1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AAC3
  • mitochondrion
  • mitochondrial inner membrane
  • anaerobic respiration
  • ATP:ADP antiporter activity
  • ADH2
  • cytoplasm
  • fermentation
  • ethanol metabolic process
  • NADH oxidation
  • alcohol dehydrogenase (NAD) activity
  • AHP1
  • cytoplasm
  • response to oxidative stress
  • response to metal ion
  • thioredoxin peroxidase activity
  • CAR2
  • nucleus
  • cytoplasm
  • arginine catabolic process
  • ornithine-oxo-acid transaminase activity
  • FOL2
  • nucleus
  • cytoplasm
  • folic acid and derivative biosynthetic process
  • GTP cyclohydrolase I activity
  • HYP2
  • cytoplasm
  • mitochondrion
  • ribosome
  • translational initiation
  • translation initiation factor activity
  • protein binding
  • ILV5
  • mitochondrion
  • mitochondrial nucleoid
  • branched chain family amino acid biosynthetic process
  • mitochondrial genome maintenance
  • ketol-acid reductoisomerase activity
  • MPC54
  • spindle pole body
  • ascospore wall assembly
  • structural molecule activity
  • OYE2
  • nucleus
  • cytoplasm
  • mitochondrion
  • biological_process
  • NADPH dehydrogenase activity
  • OYE3
  • cellular_component
  • biological_process
  • NADPH dehydrogenase activity
  • POR1
  • integral to mitochondrial outer membrane
  • mitochondrion
  • mitochondrial outer membrane
  • ion transport
  • aerobic respiration
  • mitochondrion organization
  • voltage-gated anion channel activity
  • PST2
  • cytoplasm
  • mitochondrion
  • biological_process
  • molecular_function
  • PYC2
  • cytosol
  • gluconeogenesis
  • NADPH regeneration
  • pyruvate carboxylase activity
  • SOD1
  • mitochondrial intermembrane space
  • mitochondrion
  • cytosol
  • age-dependent response to reactive oxygen species involved in chronological cell aging
  • response to cold
  • superoxide metabolic process
  • cellular copper ion homeostasis
  • response to drug
  • cellular zinc ion homeostasis
  • antioxidant activity
  • metal ion binding
  • oxidoreductase activity
  • superoxide dismutase activity
  • YBL108W
    YCK1
  • mitochondrion
  • endoplasmic reticulum
  • plasma membrane
  • response to glucose stimulus
  • cell morphogenesis
  • cytokinesis
  • protein amino acid phosphorylation
  • endocytosis
  • casein kinase I activity
  • YHR112C
  • cytoplasm
  • sulfur metabolic process
  • cystathionine beta-lyase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mitochondrion 5.3772E-3 17 1125 8 6292
    cytoplasm 5.6579E-3 17 3552 15 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    superoxide metabolic process 2.7018E-3 17 1 1 6292
    coenzyme metabolic process 3.7844E-3 17 120 3 6292
    response to inorganic substance 3.8798E-3 17 35 2 6292
    age-dependent response to reactive oxygen species 5.3968E-3 17 2 1 6292
    age-dependent response to reactive oxygen species involved in chronological cell aging 5.3968E-3 17 2 1 6292
    arginine catabolic process 5.3968E-3 17 2 1 6292
    anaerobic respiration 5.3968E-3 17 2 1 6292
    nicotinamide nucleotide metabolic process 5.8138E-3 17 43 2 6292
    pyridine nucleotide metabolic process 6.6321E-3 17 46 2 6292
    energy derivation by oxidation of organic compounds 6.9354E-3 17 149 3 6292
    cofactor metabolic process 7.5985E-3 17 154 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    NADPH dehydrogenase activity 6.8716E-6 17 2 2 6292
    oxidoreductase activity 6.1355E-5 17 281 6 6292
    oxidoreductase activity, acting on NADH or NADPH 1.4001E-3 17 21 2 6292
    antioxidant activity 1.9875E-3 17 25 2 6292
    ornithine-oxo-acid transaminase activity 2.7018E-3 17 1 1 6292
    GTP cyclohydrolase activity 2.7018E-3 17 1 1 6292
    GTP cyclohydrolase I activity 2.7018E-3 17 1 1 6292
    ketol-acid reductoisomerase activity 2.7018E-3 17 1 1 6292
    superoxide dismutase activity 5.3968E-3 17 2 1 6292
    pyruvate carboxylase activity 5.3968E-3 17 2 1 6292
    oxidoreductase activity, acting on superoxide radicals as acceptor 5.3968E-3 17 2 1 6292
    ATP:ADP antiporter activity 8.0849E-3 17 3 1 6292
    voltage-gated anion channel activity 8.0849E-3 17 3 1 6292
    anion channel activity 8.0849E-3 17 3 1 6292
    cystathionine beta-lyase activity 8.0849E-3 17 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle