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Catalysis of the elimination of H2S or substituted H2S. Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate. Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: cystathionine beta-lyase activity
Acc: GO:0004121
Aspect: Molecular Function
Desc: Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate.
Synonyms:
  • cystine lyase activity
  • L-cystathionine L-homocysteine-lyase (deaminating)
  • L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)
  • beta-cystathionase activity
  • cystathionine L-homocysteine-lyase (deaminating)
  • beta C-S lyase activity
  • GO:0008799
Proteins in PDR annotated with:
   This term: 23 [Search]
   Term or descendants: 23 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004121 - cystathionine beta-lyase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle