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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Skp1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 8 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BOP2
  • cellular_component
  • biological_process
  • molecular_function
  • CDC4
  • nucleus
  • nuclear matrix
  • SCF ubiquitin ligase complex
  • nuclear SCF ubiquitin ligase complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • meiosis
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • CDC53
  • SCF ubiquitin ligase complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • DNA replication origin binding
  • ubiquitin-protein ligase activity
  • protein binding, bridging
  • PRB1
  • fungal-type vacuole lumen
  • fungal-type vacuole
  • cellular response to starvation
  • sporulation resulting in formation of a cellular spore
  • vacuolar protein catabolic process
  • serine-type endopeptidase activity
  • SGT1
  • ubiquitin ligase complex
  • protein complex assembly
  • kinetochore assembly
  • cAMP-mediated signaling
  • protein ubiquitination
  • chaperone binding
  • SKP1
  • RAVE complex
  • nucleus
  • cytoplasm
  • CBF3 complex
  • SCF ubiquitin ligase complex
  • kinetochore
  • G2/M transition of mitotic cell cycle
  • protein complex assembly
  • regulation of exit from mitosis
  • G1/S transition of mitotic cell cycle
  • cytokinesis
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • regulation of protein complex assembly
  • protein neddylation
  • kinetochore assembly
  • vacuolar acidification
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • DNA replication origin binding
  • ubiquitin-protein ligase activity
  • protein binding
  • UFO1
  • nucleus
  • cytoplasm
  • SCF ubiquitin ligase complex
  • response to DNA damage stimulus
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • protein binding
  • YDR131C
  • ubiquitin ligase complex
  • ubiquitin-dependent protein catabolic process
  • protein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ubiquitin ligase complex 1.9655E-12 8 43 6 6292
    SCF ubiquitin ligase complex 3.528E-10 8 11 4 6292
    cullin-RING ubiquitin ligase complex 1.0685E-9 8 14 4 6292
    protein complex 6.9038E-4 8 1137 6 6292
    nuclear SCF ubiquitin ligase complex 2.5415E-3 8 2 1 6292
    nuclear matrix 2.5415E-3 8 2 1 6292
    nuclear periphery 2.5415E-3 8 2 1 6292
    RAVE complex 3.8101E-3 8 3 1 6292
    CBF3 complex 5.0773E-3 8 4 1 6292
    macromolecular complex 5.1894E-3 8 1635 6 6292
    fungal-type vacuole lumen 8.8705E-3 8 7 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cellular protein catabolic process 9.8893E-9 8 171 6 6292
    protein catabolic process 1.8092E-8 8 189 6 6292
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 4.7121E-8 8 7 3 6292
    cellular macromolecule catabolic process 1.3771E-7 8 265 6 6292
    protein ubiquitination during ubiquitin-dependent protein catabolic process 2.2161E-7 8 11 3 6292
    macromolecule catabolic process 2.5613E-7 8 294 6 6292
    modification-dependent protein catabolic process 4.6357E-7 8 156 5 6292
    ubiquitin-dependent protein catabolic process 4.6357E-7 8 156 5 6292
    proteolysis involved in cellular protein catabolic process 5.099E-7 8 159 5 6292
    modification-dependent macromolecule catabolic process 5.9524E-7 8 164 5 6292
    protein ubiquitination 7.0413E-7 8 65 4 6292
    proteolysis 1.1761E-6 8 188 5 6292
    cellular catabolic process 1.9869E-6 8 415 6 6292
    protein modification by small protein conjugation 2.1849E-6 8 86 4 6292
    centromere complex assembly 4.2416E-6 8 3 2 6292
    kinetochore assembly 4.2416E-6 8 3 2 6292
    kinetochore organization 4.2416E-6 8 3 2 6292
    G2/M transition of mitotic cell cycle 4.8552E-6 8 29 3 6292
    catabolic process 5.6904E-6 8 496 6 6292
    protein modification by small protein conjugation or removal 6.7673E-6 8 114 4 6292
    G1/S transition of mitotic cell cycle 2.5718E-5 8 50 3 6292
    cellular protein metabolic process 2.8294E-5 8 1074 7 6292
    protein metabolic process 4.153E-5 8 1136 7 6292
    proteasomal protein catabolic process 6.797E-5 8 69 3 6292
    proteasomal ubiquitin-dependent protein catabolic process 6.797E-5 8 69 3 6292
    interphase of mitotic cell cycle 1.8808E-4 8 97 3 6292
    interphase 1.8808E-4 8 97 3 6292
    post-translational protein modification 5.9444E-4 8 357 4 6292
    protein-DNA complex assembly 1.0239E-3 8 39 2 6292
    cellular protein complex assembly 1.9586E-3 8 54 2 6292
    protein modification process 2.1135E-3 8 499 4 6292
    mitotic cell cycle 3.1661E-3 8 255 3 6292
    organelle assembly 3.1803E-3 8 69 2 6292
    macromolecule modification 3.4456E-3 8 569 4 6292
    cellular macromolecule metabolic process 4.5244E-3 8 2285 7 6292
    macromolecule metabolic process 5.4192E-3 8 2349 7 6292
    cyclic-nucleotide-mediated signaling 8.8705E-3 8 7 1 6292
    protein neddylation 8.8705E-3 8 7 1 6292
    cAMP-mediated signaling 8.8705E-3 8 7 1 6292
    cell cycle phase 9.4607E-3 8 376 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ubiquitin-protein ligase activity 4.125E-7 8 57 4 6292
    small conjugating protein ligase activity 5.8106E-7 8 62 4 6292
    acid-amino acid ligase activity 1.0074E-6 8 71 4 6292
    ligase activity, forming carbon-nitrogen bonds 3.1247E-6 8 94 4 6292
    ligase activity 2.0169E-5 8 150 4 6292
    DNA replication origin binding 1.0958E-4 8 13 2 6292
    protein binding 3.7374E-4 8 612 5 6292
    sequence-specific DNA binding 1.6809E-3 8 50 2 6292
    serine-type endopeptidase activity 5.0773E-3 8 4 1 6292
    serine-type peptidase activity 7.6075E-3 8 6 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle