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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Hta1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 14 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
HHF1, HHF2
  • nucleus
  • nucleoplasm part
  • nuclear nucleosome
  • chromosome
  • replication fork protection complex
  • chromatin remodeling complex
  • nucleosome
  • histone acetyltransferase complex
  • nucleoplasm
  • histone H3-K79 methylation
  • DNA repair
  • negative regulation of transcription
  • chromatin assembly or disassembly
  • positive regulation of transcription
  • nucleosome assembly
  • DNA binding
  • HIR2
  • nucleus
  • HIR complex
  • DNA replication-independent nucleosome assembly
  • regulation of transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • transcription corepressor activity
  • HTA1
  • nuclear nucleosome
  • DNA repair
  • chromatin assembly or disassembly
  • DNA binding
  • HTB1
  • nuclear nucleosome
  • chromatin assembly or disassembly
  • postreplication repair
  • DNA binding
  • KAP114
  • nucleus
  • cytoplasm
  • protein import into nucleus
  • protein transmembrane transporter activity
  • KRI1
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • NAP1
  • nucleus
  • cytoplasm
  • nuclear nucleosome
  • M phase of mitotic cell cycle
  • budding cell bud growth
  • nucleosome assembly
  • histone binding
  • NOP4
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • RET1
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • DNA-directed RNA polymerase activity
  • RPC82
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • RPO31
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • DNA-directed RNA polymerase activity
  • SPT16
  • FACT complex
  • nuclear chromatin
  • alpha DNA polymerase:primase complex
  • transcription elongation factor complex
  • transcription initiation from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • transcription elongation regulator activity
  • RNA polymerase II transcription elongation factor activity
  • UTP13
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • snoRNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear nucleosome 7.5177E-9 14 12 4 6292
    nucleosome 7.5177E-9 14 12 4 6292
    nuclear part 5.1432E-8 14 1103 12 6292
    protein-DNA complex 9.6002E-8 14 57 5 6292
    nuclear chromatin 3.3783E-7 14 73 5 6292
    chromatin 4.4225E-7 14 77 5 6292
    nuclear lumen 1.3863E-6 14 453 8 6292
    nucleus 4.2048E-6 14 2041 13 6292
    DNA-directed RNA polymerase III complex 5.8562E-6 14 17 3 6292
    organelle lumen 2.375E-5 14 660 8 6292
    intracellular organelle lumen 2.375E-5 14 660 8 6292
    membrane-enclosed lumen 3.6727E-5 14 700 8 6292
    DNA-directed RNA polymerase complex 3.8006E-5 14 31 3 6292
    RNA polymerase complex 3.8006E-5 14 31 3 6292
    nuclear DNA-directed RNA polymerase complex 3.8006E-5 14 31 3 6292
    nuclear chromosome part 3.8206E-5 14 190 5 6292
    nuclear chromosome 9.1578E-5 14 228 5 6292
    chromosomal part 1.1011E-4 14 237 5 6292
    nucleoplasm part 1.289E-4 14 245 5 6292
    nucleoplasm 1.835E-4 14 264 5 6292
    intracellular organelle part 2.0575E-4 14 2282 12 6292
    organelle part 2.0575E-4 14 2282 12 6292
    chromosome 2.186E-4 14 274 5 6292
    non-membrane-bounded organelle 3.6012E-4 14 959 8 6292
    intracellular non-membrane-bounded organelle 3.6012E-4 14 959 8 6292
    macromolecular complex 4.733E-4 14 1635 10 6292
    nuclear replication fork 8.5383E-4 14 20 2 6292
    replication fork 3.7625E-3 14 42 2 6292
    FACT complex 4.4455E-3 14 2 1 6292
    replication fork protection complex 4.4455E-3 14 2 1 6292
    membrane-bounded organelle 7.9402E-3 14 3771 13 6292
    intracellular membrane-bounded organelle 7.9402E-3 14 3771 13 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    chromatin assembly or disassembly 7.642E-9 14 35 5 6292
    cellular component biogenesis 2.7585E-6 14 694 9 6292
    nucleosome assembly 4.8291E-6 14 16 3 6292
    chromatin assembly 8.3233E-6 14 19 3 6292
    nucleic acid metabolic process 1.3226E-5 14 1415 11 6292
    nucleosome organization 3.0977E-5 14 29 3 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.7241E-5 14 1566 11 6292
    DNA packaging 4.1883E-5 14 32 3 6292
    chromatin organization 5.2536E-5 14 203 5 6292
    transcription from RNA polymerase III promoter 7.0675E-5 14 38 3 6292
    protein-DNA complex assembly 7.6464E-5 14 39 3 6292
    cellular nitrogen compound metabolic process 1.2791E-4 14 1770 11 6292
    nitrogen compound metabolic process 1.439E-4 14 1791 11 6292
    DNA conformation change 2.5179E-4 14 58 3 6292
    RNA metabolic process 3.4699E-4 14 954 8 6292
    gene expression 4.3778E-4 14 1283 9 6292
    ribosome biogenesis 6.4733E-4 14 346 5 6292
    transcription 7.2178E-4 14 552 6 6292
    ribonucleoprotein complex biogenesis 9.2471E-4 14 374 5 6292
    cellular macromolecule metabolic process 1.557E-3 14 2285 11 6292
    macromolecule metabolic process 2.0248E-3 14 2349 11 6292
    histone H3-K79 methylation 2.225E-3 14 1 1 6292
    rRNA processing 2.5404E-3 14 128 3 6292
    macromolecular complex assembly 2.7315E-3 14 281 4 6292
    rRNA metabolic process 3.0829E-3 14 137 3 6292
    RNA elongation from RNA polymerase II promoter 3.2505E-3 14 39 2 6292
    transcription, DNA-dependent 3.4885E-3 14 503 5 6292
    RNA biosynthetic process 3.6431E-3 14 508 5 6292
    RNA elongation 4.3098E-3 14 45 2 6292
    histone lysine methylation 4.4455E-3 14 2 1 6292
    chromosome organization 5.3538E-3 14 555 5 6292
    macromolecular complex subunit organization 6.4746E-3 14 357 4 6292
    cellular macromolecular complex assembly 6.8483E-3 14 182 3 6292
    cellular process 7.2188E-3 14 4426 14 6292
    maturation of SSU-rRNA 7.3172E-3 14 59 2 6292
    DNA repair 7.9417E-3 14 192 3 6292
    cellular component assembly 8.4529E-3 14 385 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA polymerase activity 5.0397E-5 14 34 3 6292
    DNA-directed RNA polymerase activity 5.0397E-5 14 34 3 6292
    binding 2.858E-3 14 1294 8 6292
    nucleotidyltransferase activity 5.4793E-3 14 168 3 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle