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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Nop2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 18 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRX1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • 5S rRNA binding
  • rRNA primary transcript binding
  • CKB1
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 regulator activity
  • COX6
  • mitochondrion
  • mitochondrial respiratory chain complex IV
  • mitochondrial electron transport, cytochrome c to oxygen
  • cytochrome-c oxidase activity
  • FET4
  • integral to plasma membrane
  • plasma membrane
  • low-affinity iron ion transport
  • intracellular copper ion transport
  • copper ion import
  • iron ion transmembrane transporter activity
  • copper ion transmembrane transporter activity
  • GAR1
  • box H/ACA snoRNP complex
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • ribosome biogenesis
  • RNA binding
  • NIP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • molecular_function
  • NMD3
  • cytosol
  • ribosomal large subunit export from nucleus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • RNA binding
  • protein binding
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP1
  • nuclear outer membrane
  • nucleolus
  • ribosome
  • small nucleolar ribonucleoprotein complex
  • rRNA modification
  • RNA methylation
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • snoRNA 3'-end processing
  • methyltransferase activity
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP56
  • box C/D snoRNP complex
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • rRNA modification
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • molecular_function
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • NSA2
  • nucleus
  • preribosome, large subunit precursor
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PHO84
  • integral to plasma membrane
  • phosphate transport
  • manganese ion transport
  • inorganic phosphate transmembrane transporter activity
  • manganese ion transmembrane transporter activity
  • RRP1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • YPL009C
  • cytoplasm
  • ribosome
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 1.2073E-12 18 211 11 6292
    nuclear lumen 4.8008E-9 18 453 11 6292
    organelle lumen 2.492E-7 18 660 11 6292
    intracellular organelle lumen 2.492E-7 18 660 11 6292
    membrane-enclosed lumen 4.5725E-7 18 700 11 6292
    non-membrane-bounded organelle 1.1217E-6 18 959 12 6292
    intracellular non-membrane-bounded organelle 1.1217E-6 18 959 12 6292
    nuclear part 4.3738E-5 18 1103 11 6292
    nucleolar part 2.5882E-4 18 45 3 6292
    preribosome, large subunit precursor 2.7502E-4 18 9 2 6292
    small nucleolar ribonucleoprotein complex 1.0365E-3 18 72 3 6292
    nuclear outer membrane 1.7345E-3 18 86 3 6292
    ribonucleoprotein complex 2.2861E-3 18 514 6 6292
    nuclear membrane 2.4501E-3 18 97 3 6292
    nucleus 2.9926E-3 18 2041 12 6292
    integral to plasma membrane 2.9982E-3 18 29 2 6292
    intrinsic to plasma membrane 3.8728E-3 18 33 2 6292
    preribosome 4.1079E-3 18 34 2 6292
    box C/D snoRNP complex 5.7138E-3 18 2 1 6292
    box H/ACA snoRNP complex 5.7138E-3 18 2 1 6292
    Noc2p-Noc3p complex 5.7138E-3 18 2 1 6292
    Noc1p-Noc2p complex 5.7138E-3 18 2 1 6292
    membrane part 8.1216E-3 18 662 6 6292
    intracellular organelle part 8.4564E-3 18 2282 12 6292
    organelle part 8.4564E-3 18 2282 12 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 2.2556E-13 18 346 13 6292
    ribonucleoprotein complex biogenesis 6.1751E-13 18 374 13 6292
    ribosomal large subunit biogenesis 2.6249E-10 18 65 7 6292
    cellular component biogenesis 1.6304E-9 18 694 13 6292
    rRNA processing 3.2326E-8 18 128 7 6292
    rRNA metabolic process 5.1867E-8 18 137 7 6292
    ribosome assembly 7.1898E-7 18 64 5 6292
    organelle assembly 1.0506E-6 18 69 5 6292
    ncRNA processing 1.1396E-6 18 215 7 6292
    ncRNA metabolic process 3.7807E-6 18 257 7 6292
    ribonucleoprotein complex assembly 4.4174E-6 18 92 5 6292
    ribosomal large subunit assembly 4.4463E-6 18 41 4 6292
    ribosomal subunit assembly 1.4604E-5 18 55 4 6292
    RNA processing 4.9348E-5 18 380 7 6292
    cellular macromolecular complex assembly 1.2088E-4 18 182 5 6292
    maturation of SSU-rRNA 5.7827E-4 18 59 3 6292
    cellular macromolecular complex subunit organization 6.2655E-4 18 259 5 6292
    macromolecular complex assembly 9.088E-4 18 281 5 6292
    rRNA modification 1.1511E-3 18 18 2 6292
    establishment of ribosome localization 2.4123E-3 18 26 2 6292
    ribosome localization 2.4123E-3 18 26 2 6292
    ribosomal subunit export from nucleus 2.4123E-3 18 26 2 6292
    macromolecular complex subunit organization 2.6496E-3 18 357 5 6292
    low-affinity iron ion transport 2.8608E-3 18 1 1 6292
    RNA metabolic process 2.8721E-3 18 954 8 6292
    cellular component assembly 3.6848E-3 18 385 5 6292
    transition metal ion transport 6.5123E-3 18 43 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    inorganic cation transmembrane transporter activity 2.7496E-3 18 101 3 6292
    transition metal ion transmembrane transporter activity 2.7962E-3 18 28 2 6292
    cation transmembrane transporter activity 4.2718E-3 18 118 3 6292
    di-, tri-valent inorganic cation transmembrane transporter activity 4.3495E-3 18 35 2 6292
    5S rRNA binding 5.7138E-3 18 2 1 6292
    protein kinase CK2 regulator activity 5.7138E-3 18 2 1 6292
    metal ion transmembrane transporter activity 7.4266E-3 18 46 2 6292
    ion transmembrane transporter activity 7.7338E-3 18 146 3 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle