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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 6 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
DNA2
  • nucleus
  • nuclear chromosome, telomeric region
  • DNA repair
  • lagging strand elongation
  • DNA-dependent DNA replication
  • telomere maintenance
  • replicative cell aging
  • 5'-flap endonuclease activity
  • ATP-dependent DNA helicase activity
  • single-stranded DNA specific endodeoxyribonuclease activity
  • HSP12
  • nucleus
  • cytoplasm
  • plasma membrane
  • response to oxidative stress
  • response to heat
  • response to desiccation
  • cell adhesion
  • hyperosmotic response
  • molecular_function
  • PRO1
  • cytoplasm
  • telomere maintenance
  • ribosome biogenesis
  • proline biosynthetic process
  • glutamate 5-kinase activity
  • RFA1
  • chromosome, telomeric region
  • nucleus
  • cytoplasm
  • DNA replication factor A complex
  • DNA strand elongation involved in DNA replication
  • double-strand break repair via homologous recombination
  • DNA recombination
  • nucleotide-excision repair
  • telomere maintenance via recombination
  • DNA unwinding involved in replication
  • postreplication repair
  • DNA replication, synthesis of RNA primer
  • damaged DNA binding
  • single-stranded DNA binding
  • RFA2
  • chromosome, telomeric region
  • DNA replication factor A complex
  • DNA strand elongation involved in DNA replication
  • double-strand break repair via homologous recombination
  • DNA recombination
  • nucleotide-excision repair
  • DNA unwinding involved in replication
  • postreplication repair
  • DNA replication, synthesis of RNA primer
  • DNA binding
  • RFA3
  • chromosome, telomeric region
  • DNA replication factor A complex
  • DNA strand elongation involved in DNA replication
  • double-strand break repair via homologous recombination
  • DNA recombination
  • nucleotide-excision repair
  • DNA unwinding involved in replication
  • postreplication repair
  • DNA replication, synthesis of RNA primer
  • DNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA replication factor A complex 4.8197E-10 6 3 3 6292
    chromosome, telomeric region 4.0114E-9 6 27 4 6292
    nuclear replisome 3.9118E-7 6 18 3 6292
    replisome 3.9118E-7 6 18 3 6292
    nuclear replication fork 5.4611E-7 6 20 3 6292
    replication fork 5.4562E-6 6 42 3 6292
    nuclear chromosome part 1.1529E-5 6 190 4 6292
    protein-DNA complex 1.3832E-5 6 57 3 6292
    nuclear chromosome 2.3796E-5 6 228 4 6292
    chromosomal part 2.7744E-5 6 237 4 6292
    chromosome 4.9256E-5 6 274 4 6292
    non-membrane-bounded organelle 6.2191E-3 6 959 4 6292
    intracellular non-membrane-bounded organelle 6.2191E-3 6 959 4 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA replication, synthesis of RNA primer 4.8163E-9 6 5 3 6292
    DNA strand elongation 7.1846E-9 6 31 4 6292
    DNA strand elongation involved in DNA replication 7.1846E-9 6 31 4 6292
    DNA unwinding involved in replication 1.7475E-7 6 14 3 6292
    postreplication repair 3.9118E-7 6 18 3 6292
    DNA-dependent DNA replication 3.9419E-7 6 82 4 6292
    DNA geometric change 5.4611E-7 6 20 3 6292
    DNA duplex unwinding 5.4611E-7 6 20 3 6292
    double-strand break repair via homologous recombination 7.372E-7 6 22 3 6292
    recombinational repair 1.2428E-6 6 26 3 6292
    DNA replication 2.0246E-6 6 123 4 6292
    nucleotide-excision repair 4.0152E-6 6 38 3 6292
    DNA repair 1.2019E-5 6 192 4 6292
    double-strand break repair 1.3832E-5 6 57 3 6292
    DNA conformation change 1.4581E-5 6 58 3 6292
    response to stress 1.6929E-5 6 497 5 6292
    response to DNA damage stimulus 2.7283E-5 6 236 4 6292
    DNA metabolic process 3.7887E-5 6 585 5 6292
    cellular response to stress 6.1624E-5 6 290 4 6292
    DNA recombination 1.1136E-4 6 114 3 6292
    response to stimulus 1.4262E-4 6 766 5 6292
    cellular response to stimulus 1.7644E-4 6 379 4 6292
    anatomical structure homeostasis 1.6779E-3 6 286 3 6292
    telomere organization 1.6779E-3 6 286 3 6292
    telomere maintenance 1.6779E-3 6 286 3 6292
    nucleic acid metabolic process 2.791E-3 6 1415 5 6292
    proline biosynthetic process 2.8585E-3 6 3 1 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.5228E-3 6 1566 5 6292
    cellular biosynthetic process 4.5365E-3 6 1567 5 6292
    homeostatic process 4.6706E-3 6 408 3 6292
    biosynthetic process 5.0373E-3 6 1602 5 6292
    proline metabolic process 6.6592E-3 6 7 1 6292
    cell adhesion 7.6075E-3 6 8 1 6292
    response to water deprivation 7.6075E-3 6 8 1 6292
    response to desiccation 7.6075E-3 6 8 1 6292
    biological adhesion 7.6075E-3 6 8 1 6292
    cellular nitrogen compound metabolic process 8.0643E-3 6 1770 5 6292
    nitrogen compound metabolic process 8.5237E-3 6 1791 5 6292
    RNA biosynthetic process 8.6959E-3 6 508 3 6292
    hyperosmotic response 9.5019E-3 6 10 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    glutamate 5-kinase activity 9.5359E-4 6 1 1 6292
    DNA binding 1.2152E-3 6 256 3 6292
    amino acid kinase activity 2.8585E-3 6 3 1 6292
    endodeoxyribonuclease activity, producing 5'-phosphomonoesters 4.7604E-3 6 5 1 6292
    phosphotransferase activity, carboxyl group as acceptor 4.7604E-3 6 5 1 6292
    5'-flap endonuclease activity 4.7604E-3 6 5 1 6292
    flap endonuclease activity 4.7604E-3 6 5 1 6292
    single-stranded DNA specific endodeoxyribonuclease activity 6.6592E-3 6 7 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle