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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 8 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AKL1
  • cytoplasm
  • cellular bud neck
  • regulation of endocytosis
  • actin cytoskeleton organization
  • protein kinase activity
  • HOS4
  • histone deacetylase complex
  • histone deacetylation
  • negative regulation of meiosis
  • NAD-dependent histone deacetylase activity
  • NAD-independent histone deacetylase activity
  • HST1
  • nucleus
  • histone deacetylase complex
  • telomere maintenance
  • chromatin silencing
  • negative regulation of mitotic recombination
  • NAD-dependent histone deacetylase activity
  • NAD-independent histone deacetylase activity
  • RFM1
  • nucleus
  • histone deacetylase complex
  • telomere maintenance
  • chromatin silencing
  • unfolded protein binding
  • SET3
  • histone deacetylase complex
  • histone deacetylation
  • negative regulation of meiosis
  • NAD-dependent histone deacetylase activity
  • NAD-independent histone deacetylase activity
  • SIF2
  • nucleus
  • histone deacetylase complex
  • negative regulation of transcription from RNA polymerase II promoter
  • histone deacetylation
  • chromatin silencing at telomere
  • negative regulation of meiosis
  • transcription corepressor activity
  • NAD-dependent histone deacetylase activity
  • NAD-independent histone deacetylase activity
  • SNT1
  • histone deacetylase complex
  • histone deacetylation
  • negative regulation of meiosis
  • NAD-dependent histone deacetylase activity
  • NAD-independent histone deacetylase activity
  • SUM1
  • nucleus
  • histone deacetylase complex
  • regulation of mitosis
  • negative regulation of transcription
  • telomere maintenance
  • chromatin silencing at silent mating-type cassette
  • chromatin silencing at telomere
  • transcription repressor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone deacetylase complex 2.5347E-17 8 23 7 6292
    chromatin remodeling complex 1.5229E-12 8 99 7 6292
    nucleoplasm part 9.6603E-10 8 245 7 6292
    nucleoplasm 1.6353E-9 8 264 7 6292
    nuclear lumen 7.205E-8 8 453 7 6292
    organelle lumen 9.8757E-7 8 660 7 6292
    intracellular organelle lumen 9.8757E-7 8 660 7 6292
    membrane-enclosed lumen 1.4845E-6 8 700 7 6292
    nuclear part 3.3951E-5 8 1103 7 6292
    protein complex 4.178E-5 8 1137 7 6292
    macromolecular complex 4.9027E-4 8 1635 7 6292
    nucleus 2.1521E-3 8 2041 7 6292
    organelle part 4.4856E-3 8 2282 7 6292
    intracellular organelle part 4.4856E-3 8 2282 7 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    negative regulation of meiosis 7.4952E-11 8 8 4 6292
    negative regulation of cellular process 1.1139E-9 8 250 7 6292
    negative regulation of biological process 1.2116E-9 8 253 7 6292
    regulation of meiosis 7.7768E-9 8 22 4 6292
    regulation of meiotic cell cycle 7.7768E-9 8 22 4 6292
    regulation of cell cycle process 1.6964E-8 8 81 5 6292
    histone deacetylation 1.861E-8 8 27 4 6292
    protein amino acid deacetylation 2.516E-8 8 29 4 6292
    negative regulation of cell cycle process 3.8035E-8 8 32 4 6292
    regulation of cellular process 6.3621E-8 8 796 8 6292
    regulation of biological process 8.3992E-8 8 824 8 6292
    regulation of cell cycle 1.9312E-7 8 131 5 6292
    chromosome organization 2.9656E-7 8 555 7 6292
    organelle organization 1.038E-6 8 1127 8 6292
    biological regulation 1.8727E-6 8 1213 8 6292
    covalent chromatin modification 2.3967E-6 8 88 4 6292
    histone modification 2.3967E-6 8 88 4 6292
    negative regulation of gene expression, epigenetic 4.0055E-6 8 100 4 6292
    gene silencing 4.0055E-6 8 100 4 6292
    regulation of gene expression, epigenetic 4.0055E-6 8 100 4 6292
    chromatin silencing 4.0055E-6 8 100 4 6292
    M phase 1.074E-5 8 294 5 6292
    cellular component organization 1.5761E-5 8 1582 8 6292
    negative regulation of transcription, DNA-dependent 2.4161E-5 8 157 4 6292
    negative regulation of RNA metabolic process 2.4776E-5 8 158 4 6292
    meiosis 2.604E-5 8 160 4 6292
    M phase of meiotic cell cycle 2.604E-5 8 160 4 6292
    negative regulation of transcription 2.8711E-5 8 164 4 6292
    meiotic cell cycle 2.8711E-5 8 164 4 6292
    negative regulation of gene expression 2.8711E-5 8 164 4 6292
    chromatin modification 3.1578E-5 8 168 4 6292
    cell cycle phase 3.5782E-5 8 376 5 6292
    negative regulation of macromolecule biosynthetic process 3.7098E-5 8 175 4 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.1456E-5 8 180 4 6292
    negative regulation of nitrogen compound metabolic process 4.1456E-5 8 180 4 6292
    negative regulation of biosynthetic process 5.0235E-5 8 189 4 6292
    negative regulation of cellular biosynthetic process 5.0235E-5 8 189 4 6292
    negative regulation of macromolecule metabolic process 5.3445E-5 8 192 4 6292
    chromatin organization 6.6519E-5 8 203 4 6292
    negative regulation of cellular metabolic process 7.457E-5 8 209 4 6292
    negative regulation of metabolic process 7.5978E-5 8 210 4 6292
    cell cycle process 1.2901E-4 8 490 5 6292
    cell cycle 1.7971E-4 8 525 5 6292
    post-translational protein modification 5.9444E-4 8 357 4 6292
    regulation of transcription, DNA-dependent 6.0084E-4 8 358 4 6292
    regulation of RNA metabolic process 6.3358E-4 8 363 4 6292
    regulation of transcription 7.8534E-4 8 384 4 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.055E-3 8 415 4 6292
    regulation of nitrogen compound metabolic process 1.0647E-3 8 416 4 6292
    regulation of gene expression 1.374E-3 8 445 4 6292
    regulation of macromolecule biosynthetic process 1.5066E-3 8 456 4 6292
    regulation of cellular biosynthetic process 1.7154E-3 8 472 4 6292
    regulation of biosynthetic process 1.7291E-3 8 473 4 6292
    regulation of macromolecule metabolic process 1.9441E-3 8 488 4 6292
    chromatin silencing at telomere 2.0312E-3 8 55 2 6292
    protein modification process 2.1135E-3 8 499 4 6292
    transcription, DNA-dependent 2.1776E-3 8 503 4 6292
    RNA biosynthetic process 2.2596E-3 8 508 4 6292
    regulation of primary metabolic process 2.361E-3 8 514 4 6292
    regulation of cellular metabolic process 2.7603E-3 8 536 4 6292
    regulation of metabolic process 2.9768E-3 8 547 4 6292
    transcription 3.0791E-3 8 552 4 6292
    macromolecule modification 3.4456E-3 8 569 4 6292
    regulation of cellular component organization 3.7475E-3 8 75 2 6292
    negative regulation of mitotic recombination 3.8101E-3 8 3 1 6292
    regulation of endocytosis 3.8101E-3 8 3 1 6292
    anatomical structure homeostasis 4.3888E-3 8 286 3 6292
    telomere organization 4.3888E-3 8 286 3 6292
    telomere maintenance 4.3888E-3 8 286 3 6292
    cellular macromolecule metabolic process 4.5244E-3 8 2285 7 6292
    macromolecule metabolic process 5.4192E-3 8 2349 7 6292
    regulation of mitotic recombination 6.3431E-3 8 5 1 6292
    regulation of vesicle-mediated transport 7.6075E-3 8 6 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    NAD-independent histone deacetylase activity 1.4322E-14 8 7 5 6292
    NAD-dependent protein deacetylase activity 8.5861E-14 8 9 5 6292
    NAD-dependent histone deacetylase activity 8.5861E-14 8 9 5 6292
    protein deacetylase activity 1.3597E-10 8 32 5 6292
    histone deacetylase activity 1.3597E-10 8 32 5 6292
    deacetylase activity 2.1894E-10 8 35 5 6292
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1.1488E-9 8 48 5 6292
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1.5923E-8 8 80 5 6292
    transcription repressor activity 1.303E-3 8 44 2 6292
    hydrolase activity 2.4085E-3 8 911 5 6292

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