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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 7 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRE2
  • Set1C/COMPASS complex
  • transcription
  • histone methylation
  • telomere maintenance
  • chromatin silencing at telomere
  • histone methyltransferase activity (H3-K4 specific)
  • transcription regulator activity
  • SDC1
  • Set1C/COMPASS complex
  • histone methylation
  • chromatin silencing at telomere
  • histone methyltransferase activity (H3-K4 specific)
  • SET1
  • Set1C/COMPASS complex
  • ascospore formation
  • chromatin silencing at rDNA
  • histone methylation
  • telomere maintenance
  • chromatin silencing at silent mating-type cassette
  • chromatin silencing at telomere
  • peptidyl-lysine dimethylation
  • histone methyltransferase activity (H3-K4 specific)
  • histone methyltransferase activity
  • protein-lysine N-methyltransferase activity
  • SHG1
  • Set1C/COMPASS complex
  • nucleus
  • histone methylation
  • histone methyltransferase activity (H3-K4 specific)
  • SPP1
  • Set1C/COMPASS complex
  • histone methylation
  • regulation of transcription, DNA-dependent
  • chromatin silencing at telomere
  • histone methyltransferase activity (H3-K4 specific)
  • SWD1
  • Set1C/COMPASS complex
  • histone methylation
  • telomere maintenance
  • regulation of transcription, DNA-dependent
  • chromatin silencing at telomere
  • histone methyltransferase activity (H3-K4 specific)
  • SWD2
  • Set1C/COMPASS complex
  • mRNA cleavage and polyadenylation specificity factor complex
  • termination of RNA polymerase II transcription, poly(A)-coupled
  • termination of RNA polymerase II transcription, poly(A)-independent
  • histone methylation
  • telomere maintenance
  • mRNA 3'-end processing
  • snoRNA 3'-end processing
  • histone methyltransferase activity (H3-K4 specific)
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    Set1C/COMPASS complex 1.0362E-22 7 8 7 6292
    methyltransferase complex 1.0362E-22 7 8 7 6292
    histone methyltransferase complex 1.0362E-22 7 8 7 6292
    chromatin remodeling complex 1.9283E-13 7 99 7 6292
    nucleoplasm part 1.2489E-10 7 245 7 6292
    nucleoplasm 2.1199E-10 7 264 7 6292
    nuclear lumen 9.6025E-9 7 453 7 6292
    organelle lumen 1.3579E-7 7 660 7 6292
    intracellular organelle lumen 1.3579E-7 7 660 7 6292
    membrane-enclosed lumen 2.0537E-7 7 700 7 6292
    nuclear part 5.0081E-6 7 1103 7 6292
    protein complex 6.1975E-6 7 1137 7 6292
    macromolecular complex 7.9244E-5 7 1635 7 6292
    nucleus 3.7528E-4 7 2041 7 6292
    organelle part 8.2061E-4 7 2282 7 6292
    intracellular organelle part 8.2061E-4 7 2282 7 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone methylation 1.0041E-18 7 20 7 6292
    protein amino acid alkylation 4.483E-18 7 24 7 6292
    protein amino acid methylation 4.483E-18 7 24 7 6292
    macromolecule methylation 4.1739E-16 7 43 7 6292
    methylation 4.1739E-16 7 43 7 6292
    one-carbon metabolic process 2.6285E-15 7 55 7 6292
    covalent chromatin modification 8.2228E-14 7 88 7 6292
    histone modification 8.2228E-14 7 88 7 6292
    chromatin modification 8.5525E-12 7 168 7 6292
    chromatin organization 3.2884E-11 7 203 7 6292
    chromatin silencing at telomere 8.7861E-10 7 55 5 6292
    post-translational protein modification 1.7902E-9 7 357 7 6292
    negative regulation of gene expression, epigenetic 1.8787E-8 7 100 5 6292
    gene silencing 1.8787E-8 7 100 5 6292
    regulation of gene expression, epigenetic 1.8787E-8 7 100 5 6292
    chromatin silencing 1.8787E-8 7 100 5 6292
    protein modification process 1.8979E-8 7 499 7 6292
    chromosome organization 4.0131E-8 7 555 7 6292
    macromolecule modification 4.7822E-8 7 569 7 6292
    negative regulation of transcription, DNA-dependent 1.8317E-7 7 157 5 6292
    negative regulation of RNA metabolic process 1.8911E-7 7 158 5 6292
    negative regulation of transcription 2.2801E-7 7 164 5 6292
    negative regulation of gene expression 2.2801E-7 7 164 5 6292
    negative regulation of macromolecule biosynthetic process 3.1574E-7 7 175 5 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.636E-7 7 180 5 6292
    negative regulation of nitrogen compound metabolic process 3.636E-7 7 180 5 6292
    small molecule metabolic process 3.6609E-7 7 760 7 6292
    negative regulation of biosynthetic process 4.6416E-7 7 189 5 6292
    negative regulation of cellular biosynthetic process 4.6416E-7 7 189 5 6292
    negative regulation of macromolecule metabolic process 5.022E-7 7 192 5 6292
    negative regulation of cellular metabolic process 7.673E-7 7 209 5 6292
    negative regulation of metabolic process 7.858E-7 7 210 5 6292
    transcription, DNA-dependent 1.657E-6 7 503 6 6292
    RNA biosynthetic process 1.7576E-6 7 508 6 6292
    negative regulation of cellular process 1.8729E-6 7 250 5 6292
    negative regulation of biological process 1.9874E-6 7 253 5 6292
    transcription 2.8813E-6 7 552 6 6292
    cellular protein metabolic process 4.1538E-6 7 1074 7 6292
    organelle organization 5.8249E-6 7 1127 7 6292
    protein metabolic process 6.1593E-6 7 1136 7 6292
    regulation of transcription, DNA-dependent 1.1082E-5 7 358 5 6292
    regulation of RNA metabolic process 1.1866E-5 7 363 5 6292
    regulation of transcription 1.5651E-5 7 384 5 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.292E-5 7 415 5 6292
    regulation of nitrogen compound metabolic process 2.3192E-5 7 416 5 6292
    regulation of gene expression 3.2272E-5 7 445 5 6292
    regulation of macromolecule biosynthetic process 3.637E-5 7 456 5 6292
    regulation of cellular biosynthetic process 4.3052E-5 7 472 5 6292
    regulation of biosynthetic process 4.35E-5 7 473 5 6292
    regulation of macromolecule metabolic process 5.0667E-5 7 488 5 6292
    cellular component organization 6.2893E-5 7 1582 7 6292
    regulation of primary metabolic process 6.5267E-5 7 514 5 6292
    RNA metabolic process 7.3069E-5 7 954 6 6292
    regulation of cellular metabolic process 8.0046E-5 7 536 5 6292
    regulation of metabolic process 8.836E-5 7 547 5 6292
    anatomical structure homeostasis 1.3125E-4 7 286 4 6292
    telomere organization 1.3125E-4 7 286 4 6292
    telomere maintenance 1.3125E-4 7 286 4 6292
    cellular macromolecule biosynthetic process 2.6203E-4 7 1187 6 6292
    macromolecule biosynthetic process 2.6461E-4 7 1189 6 6292
    biological regulation 2.9723E-4 7 1213 6 6292
    gene expression 4.1171E-4 7 1283 6 6292
    homeostatic process 5.2115E-4 7 408 4 6292
    regulation of cellular process 5.3954E-4 7 796 5 6292
    regulation of biological process 6.3633E-4 7 824 5 6292
    nucleic acid metabolic process 7.2556E-4 7 1415 6 6292
    cellular macromolecule metabolic process 8.282E-4 7 2285 7 6292
    macromolecule metabolic process 1.0051E-3 7 2349 7 6292
    peptidyl-lysine dimethylation 1.1125E-3 7 1 1 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.3005E-3 7 1566 6 6292
    cellular biosynthetic process 1.3053E-3 7 1567 6 6292
    biosynthetic process 1.4816E-3 7 1602 6 6292
    regulation of biological quality 1.6425E-3 7 551 4 6292
    DNA metabolic process 2.0595E-3 7 585 4 6292
    peptidyl-lysine methylation 2.224E-3 7 2 1 6292
    cellular nitrogen compound metabolic process 2.6186E-3 7 1770 6 6292
    nitrogen compound metabolic process 2.8003E-3 7 1791 6 6292
    peptidyl-lysine modification 3.3344E-3 7 3 1 6292
    primary metabolic process 4.3588E-3 7 2896 7 6292
    snoRNA 3'-end processing 5.552E-3 7 5 1 6292
    cellular metabolic process 6.026E-3 7 3033 7 6292
    snoRNA processing 7.7654E-3 7 7 1 6292
    metabolic process 7.9792E-3 7 3157 7 6292
    termination of RNA polymerase II transcription, poly(A)-independent 9.9746E-3 7 9 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone methyltransferase activity (H3-K4 specific) 1.0362E-22 7 8 7 6292
    histone methyltransferase activity 4.663E-22 7 9 7 6292
    histone-lysine N-methyltransferase activity 4.663E-22 7 9 7 6292
    lysine N-methyltransferase activity 2.2227E-20 7 13 7 6292
    protein-lysine N-methyltransferase activity 2.2227E-20 7 13 7 6292
    protein methyltransferase activity 1.0041E-18 7 20 7 6292
    N-methyltransferase activity 6.2264E-18 7 25 7 6292
    S-adenosylmethionine-dependent methyltransferase activity 1.1264E-14 7 67 7 6292
    methyltransferase activity 1.5439E-13 7 96 7 6292
    transferase activity, transferring one-carbon groups 1.9283E-13 7 99 7 6292
    transferase activity 5.1128E-7 7 797 7 6292
    catalytic activity 5.4045E-4 7 2150 7 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle