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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 10 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
FUN12
  • mitochondrion
  • translational initiation
  • translation initiation factor activity
  • GTPase activity
  • RPL15A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL4B
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPP0
  • ribosomal large subunit assembly
  • translational elongation
  • translation
  • structural constituent of ribosome
  • RPS11A, RPS11B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPS1A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • 90S preribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS1B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • 90S preribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS3
  • preribosome, small subunit precursor
  • response to DNA damage stimulus
  • translation
  • structural constituent of ribosome
  • TOP2
  • nucleus
  • mitochondrion
  • synaptonemal complex
  • reciprocal meiotic recombination
  • DNA strand elongation involved in DNA replication
  • regulation of mitotic recombination
  • chromatin assembly or disassembly
  • DNA topological change
  • DNA topoisomerase (ATP-hydrolyzing) activity
  • UTP22
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    preribosome 1.4589E-7 10 34 4 6292
    90S preribosome 1.9436E-6 10 17 3 6292
    cytosolic ribosome 1.2199E-5 10 101 4 6292
    cytosolic small ribosomal subunit 2.3692E-5 10 38 3 6292
    cytosolic part 2.5822E-5 10 122 4 6292
    ribonucleoprotein complex 4.562E-5 10 514 6 6292
    ribosomal subunit 1.2678E-4 10 183 4 6292
    small ribosomal subunit 1.6962E-4 10 73 3 6292
    cytosol 6.8764E-4 10 284 4 6292
    ribosome 7.4443E-4 10 290 4 6292
    non-membrane-bounded organelle 1.4928E-3 10 959 6 6292
    intracellular non-membrane-bounded organelle 1.4928E-3 10 959 6 6292
    synaptonemal complex 7.9239E-3 10 5 1 6292
    preribosome, small subunit precursor 9.5019E-3 10 6 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 6.1286E-9 10 376 8 6292
    cellular macromolecule biosynthetic process 2.4546E-6 10 1187 9 6292
    macromolecule biosynthetic process 2.4913E-6 10 1189 9 6292
    gene expression 4.872E-6 10 1283 9 6292
    cellular protein metabolic process 2.2894E-5 10 1074 8 6292
    cellular biosynthetic process 2.8141E-5 10 1567 9 6292
    biosynthetic process 3.4126E-5 10 1602 9 6292
    protein metabolic process 3.5183E-5 10 1136 8 6292
    cellular macromolecule metabolic process 3.9402E-5 10 2285 10 6292
    macromolecule metabolic process 5.1966E-5 10 2349 10 6292
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1.757E-4 10 13 2 6292
    primary metabolic process 4.2311E-4 10 2896 10 6292
    cellular metabolic process 6.7219E-4 10 3033 10 6292
    metabolic process 1.0041E-3 10 3157 10 6292
    ribosomal subunit assembly 3.228E-3 10 55 2 6292
    maturation of SSU-rRNA 3.7066E-3 10 59 2 6292
    ribosome assembly 4.3489E-3 10 64 2 6292
    organelle assembly 5.0393E-3 10 69 2 6292
    regulation of mitotic recombination 7.9239E-3 10 5 1 6292
    ribonucleoprotein complex assembly 8.8178E-3 10 92 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 4.9236E-9 10 212 7 6292
    structural molecule activity 1.2936E-7 10 339 7 6292
    DNA topoisomerase (ATP-hydrolyzing) activity 1.5893E-3 10 1 1 6292
    nucleic acid binding 2.094E-3 10 666 5 6292
    DNA topoisomerase activity 9.5019E-3 10 6 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle