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Protein Overview: COS2, COS3

General Information:
Name(s) found: COS3 / YML132W [SGD]
COS2 / YBR302C [SGD]
Description(s) found:
Found 39 descriptions.
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  • Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [SGD]
  • Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 379 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    fungal-type vacuole [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    cellular sodium ion homeostasis [IMPLink to PubMed article]
    Molecular Function: protein binding [IMPLink to PubMed article]
    molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR IWMLLWLPLS  60
   61 VWWKLSNNCI YPLIVSLLVL FLGPIFVLVI CGLSRKRSLS KQLIQFCKEI TENTPSSDPH 120
  121 DWEVVAANLN SYLYENNVWN TKYFFFNAMV CQEAFRTTLL EPFSLKKDKA AKVKSFKDSV 180
  181 PYIEEALGVY FTEVEKQWKL FNTEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI 240
  241 PFLNFLCCIY VSRGMCLLLR TLYLGWILFM LVQGFQNIRV LIMSMEHKMQ FLSTIINEQE 300
  301 SGANGWDEIA RKMNRYLFEK KAWKNEEFFF DGIDCEWFFN HFFYRVLSAK KSMWPLPLNV 360
  361 ELWPYIKEAQ LSRSEVLLV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) COS1 COS2, COS3 COS4 COS5 COS6 COS7 PRC1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data COS2, COS3 Huh WK, et al. (2003)
    View Data COS2, COS3 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..61] MSA 1.017985 View MSA. No confident structure predictions are available.
    2 View Details [62..169] Pfam 52.107905 DUP family No confident structure predictions are available.
    3 View Details [170..241] deduced N/A No confident structure predictions are available.
    4 View Details [242..379] Pfam 59.267606 DUP family No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle