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Protein Overview: HDAC4_MOUSE

General Information:
Name(s) found: HDAC4_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|81885062|sp|Q6NZM9.1|HDAC4_MOUSE RecName: Full=Histone deacetylase 4; Short=HD4 [NCBI NR]
  • gi|46402201|ref|NP_997108.1| histone deacetylase 4 [Mus musculus] [NCBI NR]
  • gi|41946996|gb|AAH66052.1| Histone deacetylase 4 [Mus musculus] [NCBI NR]
  • Histone deacetylase 4 OS=Mus musculus GN=Hdac4 PE=1 SV=1 [Swiss-Prot]
  • RIKEN cDNA 4932408F19 gene [HMR_022704-rand.fasta]
  • Histone deacetylase 4 [ipi.MOUSE.v3.06.fasta]
  • histone deacetylase 4 [Mus musculus]gi|41946996|gb|AAH66052.1| RIKEN cDNA 4932408F19 gene [Mus musculus] [nrdb_11152004_Chlamydomonas]
  • histone deacetylase 4 [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • Tax_Id=10090 Histone deacetylase 4 [EBI-IPI_mouse_3.06_05-10-2005_origrev_con.fasta]
  • Histone deacetylase 4 (HD4) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Histone deacetylase 4 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Hdac4 Isoform 1 of Histone deacetylase 4 [mouse-ipi-250309-contam.fasta]
  • Tax_Id=10090 Gene_Symbol=Hdac4 Isoform 1 of Histone deacetylase 4 ENSMUSG00000026313 IPI00466540 IPI00411004 IPI00652439 [IPIxENS.MOUSE_plus_REVERSE.fasta]
  • IPI:IPI00411004.5|SWISS-PROT:Q6NZM9-1|REFSEQ:NP_997108 Tax_Id=10090 Gene_Symbol=Hdac4 Isoform 1 of Histone deacetylase 4 [ipi.MOUSE.fasta.20090209]
  • Isoform 1 of Histone deacetylase 4 OS=Mus musculus GN=Hdac4 [011711_HMR.fasta]
  • sp|Q6NZM9|HDAC4_MOUSE Histone deacetylase 4 OS=Mus musculus GN=Hdac4 PE=1 SV=1 [uniprot.sptr.mouse.20130102]
    • Organism: Mus musculus
    Length: 1076 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IMP]
    Z disc [UNKNOWN]
    cytoplasm [UNKNOWN][IMP]
    histone deacetylase complex [IEA]
    cytosol [IDA]
    neuromuscular junction [IDA]
    A band [UNKNOWN]
    actomyosin [IDA]
    sarcomere [UNKNOWN]
    Biological Process: chromatin modification [IEA]
    response to denervation involved in regulation of muscle adaptation [IMP]
    transcription [IEA]
    negative regulation of cell proliferation [IDA][IMP]
    negative regulation of glycolysis [IMP]
    osteoblast development [IMP]
    regulation of transcription [IEA]
    negative regulation of osteoblast differentiation [IMP]
    negative regulation of transcription from RNA polymerase II promoter [UNKNOWN][IDA][IGI]
    skeletal system development [IMP]
    negative regulation of transcription, DNA-dependent [IDA][IMP]
    regulation of skeletal muscle fiber development [IGI]
    response to drug [UNKNOWN]
    regulation of striated muscle cell differentiation [IGI]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [IMP]
    regulation of cardiac muscle contraction by calcium ion signaling [IMP]
    Molecular Function: DNA binding [IDA]
    protein binding [IPI]
    histone deacetylase activity [UNKNOWN]
    transcription corepressor activity [IGI]
    transcription activator activity [IMP]
    transcription repressor activity [IDA][IMP]
    protein deacetylase activity [IDA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVATALPL QVAPTAVPMD LRLDHQFSLP  60
   61 LEPALREQQL QQELLALKQK QQIQRQILIA EFQRQHEQLS RQHEAQLHEH IKQQQEMLAM 120
  121 KHQQELLEHQ RKLERHRQEQ ELEKQHREQK LQQLKNKEKG KESAVASTEV KMKLQEFVLN 180
  181 KKKALAHRNL NHCISSDPRY WYGKTQHSSL DQSSPPQSGV SASYNHPVLG MYDAKDDFPL 240
  241 RKTASEPNLK LRSRLKQKVA ERRSSPLLRR KDGPVATALK KRPLDVTDSA CSSAPGSGPS 300
  301 SPNSSSGNVS TENGIAPTVP SAPAETSLAH RLVTREGSVA PLPLYTSPSL PNITLGLPAT 360
  361 GPAAGAAGQQ DAERLALPAL QQRILFPGTH LTPYLSTSPL ERDGAAAHNP LLQHMVLLEQ 420
  421 PPTQTPLVTG LGALPLHSQS LVGADRVSPS IHKLRQHRPL GRTQSAPLPQ NAQALQHLVI 480
  481 QQQHQQFLEK HKQQFQQQQL HLSKIISKPS EPPRQPESHP EETEEELREH QALLDEPYLD 540
  541 RLPGQKEPSL AGVQVKQEPI ESEEEEAEAT RETEPGQRPA TEQELLFRQQ ALLLEQQRIH 600
  601 QLRNYQASME AAGIPVSFGS HRPLSRAQSS PASATFPMSV QEPPTKPRFT TGLVYDTLML 660
  661 KHQCTCGNTN SHPEHAGRIQ SIWSRLQETG LRGKCECIRG RKATLEELQT VHSEAHTLLY 720
  721 GTNPLNRQKL DSSLTSVFVR LPCGGVGVDS DTIWNEVHSS GAARLAVGCV VELVFKVATG 780
  781 ELKNGFAVVR PPGHHAEEST PMGFCYFNSV AVAAKLLQQR LNVSKILIVD WDVHHGNGTQ 840
  841 QAFYNDPNVL YMSLHRYDDG NFFPGSGAPD EVGTGPGVGF NVNMAFTGGL EPPMGDAEYL 900
  901 AAFRTVVMPI ANEFAPDVVL VSSGFDAVEG HPTPLGGYNL SAKCFGYLTK QLMGLAGGRL 960
  961 VLALEGGHDL TAICDASEAC VSALLGNELE PLPEKVLHQR PNANAVHSME KVMDIHSKYW1020
 1021 RCLQRLSSTV GHSLIEAQKC EKEEAETVTA MASLSVGVKP AEKRSEEEPM EEEPPL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle