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Protein Overview: egr-PB

General Information:
Name(s) found: egr-PB / FBpp0087494 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene eiger is referred to in FlyBase by the symbol Dmel\egr (CG12919, FBgn0033483). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5965870..5971715. It has the cytological map location 46E1-46E3. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: immune response; asymmetric protein localization involved in cell fate determination; induction of apoptosis; JNK cascade; defense response to Gram-negative bacterium; apical protein localization. 16 alleles are reported. The phenotypes of these alleles are annotated with: eye; adult abdomen; wing. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 409 amino acids

    Gene Ontology:
    Cellular Component: membrane [IDA][ISS]
    Biological Process: immune response [IMP]
    defense response to Gram-negative bacterium [IMP]
    induction of apoptosis [IGI][IMP]
    asymmetric protein localization involved in cell fate determination [IMP]
    apoptosis [NAS]
    apical protein localization [IMP]
    JNK cascade [IGI][IMP][NAS]
    Molecular Function: protein binding [IPI]
    tumor necrosis factor receptor binding [IEA][ISS][NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAETLKPFI TPTSANDDGF PAKATSTATA QRRTRQLIPL VLGFIGLGLV VAILALTIWQ  60
   61 TTRVSHLDKE LKSLKRVVDN LQQRLGINYL DEFDEFQKEY ENALIDYPKK VDGLTDEEDD 120
  121 DDGDGLDSIA DDEDDDVSYS SVDDVGADYE DYTDMLNKLN NAHTGTTPTS ETTAEGEGET 180
  181 DSASSASNDD NVFDDFTSYN AHKKKQERKS RSIADVRNEE QNIQGNHTEL QEKSSNEATS 240
  241 KESPAPLHHR RRMHSRHRHL LVRKARSEDS RPAAHFHLSS RRRHQGSMGY HGDMYIGNDN 300
  301 ERNSYQGHFQ TRDGVLTVTN TGLYYVYAQI CYNNSHDQNG FIVFQGDTPF LQCLNTVPTN 360
  361 MPHKVHTCHT SGLIHLERNE RIHLKDIHND RNAVLREGNN RSYFGIFKV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..187] FFAS03 1.15 Crystal structure of the periplasmic chaperone Skp
    2 View Details [188..409] PSI-BLAST 32.0 Soluble part of TALL-1, sTALL-1 (BAFF)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  1.55241957936149 bayes_pls_golite062009
  • binding
    		•  1.33499069146939 bayes_pls_golite062009
  • lipopolysaccharide binding
    		•  0.499187713515374 bayes_pls_golite062009
    2
    Term Confidence Notes
  • protein binding
    		•  2.25413201891408 bayes_pls_golite062009
  • receptor binding
    		•  1.87082918048468 bayes_pls_golite062009
  • binding
    		•  1.55055236820725 bayes_pls_golite062009
  • tumor necrosis factor receptor superfamily binding
    		•  1.47525106874221 bayes_pls_golite062009
  • CD40 receptor binding
    		•  0.275062817872213 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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