Protein Overview: Spn4-PF, Spn4-PE

General Information:
Name(s) found:	Spn4-PF / FBpp0089191 [FlyBase] Spn4-PE / FBpp0089190 [FlyBase]
Description(s) found: Found 33 descriptions. SHOW ALL	The gene Serine protease inhibitor 4 is referred to in FlyBase by the symbol Dmel\Spn4 (CG9453, FBgn0028985). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2763409..2766428. It has the cytological map location 42D6. There is experimental evidence that it has the molecular function</span>: serine-type endopeptidase inhibitor activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of peptide hormone processing; negative regulation of endopeptidase activity; negative regulation of protein maturation by peptide bond cleavage. 7 alleles are reported. The phenotype of these alleles is annotated with: cephalopharyngeal skeleton. It has 11 annotated transcripts and 11 annotated polypeptides. [FlyBase] The gene Serine protease inhibitor 4 is referred to in FlyBase by the symbol Dmel\Spn4 (CG9453, FBgn0028985). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2763409..2766428. It has the cytological map location 42D6. There is experimental evidence that it has the molecular function</span>: serine-type endopeptidase inhibitor activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of peptide hormone processing; negative regulation of endopeptidase activity; negative regulation of protein maturation by peptide bond cleavage. 7 alleles are reported. The phenotype of these alleles is annotated with: cephalopharyngeal skeleton. It has 11 annotated transcripts and 11 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	411 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	negative regulation of protein maturation by peptide bond cleavage [IMP] negative regulation of peptide hormone processing [IMP] negative regulation of endopeptidase activity [IDA]
Molecular Function:	serine-type endopeptidase inhibitor activity [IDA][ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYRLVPCGC WLLPLLGLAL FPFPPVHTAD VTMADAAHQE FARRLALFSI NVYGKLSGQK  60
   61 PGENIVFSPF SIQTCAAMAR LGAENETATQ LDQGLGLASS DPEQIAHSFH QVLAAYQDSQ 120
  121 ILRIANKIFV MDGYQLRQEF DQLLSKQFLS AAQSVDFSKN VQAAATINNW VEQRTNHLIK 180
  181 DLVPADVLNS ESRLVLVNAI HFKGTWQHQF AKHLTRPDTF HLDGERTVQV PMMSLKERFR 240
  241 YADLPALDAM ALELPYKDSD LSMLIVLPNT KTGLPALEEK LRLTTLSQIT QSLYETKVAL 300
  301 KLPRFKAEFQ VELSEVFQKL GMSRMFSDQA EFGKMLQSPE PLKVSAIIHK AFIEVNEEGT 360
  361 EAAAATGMVM CYASMLTFEP QPVQFHVQHP FNYYIINKDS TILFAGRINK F

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
serine-type endopeptidase inhibitor activity	6.13717785773502	bayes_pls_golite062009
peptidase inhibitor activity	6.07523919900796	bayes_pls_golite062009
endopeptidase inhibitor activity	6.01194624525726	bayes_pls_golite062009
enzyme inhibitor activity	3.67290572457064	bayes_pls_golite062009
protease binding	2.69747551802498	bayes_pls_golite062009
enzyme regulator activity	2.47388770421699	bayes_pls_golite062009
binding	2.02049891212041	bayes_pls_golite062009
protein binding	1.90236643189719	bayes_pls_golite062009
glycosaminoglycan binding	1.61358221181146	bayes_pls_golite062009
nucleic acid binding	1.46959492426289	bayes_pls_golite062009
DNA binding	1.31854786197421	bayes_pls_golite062009
transporter activity	1.29851101299849	bayes_pls_golite062009
heparin binding	1.21540270241849	bayes_pls_golite062009
receptor activity	1.1966923866485	bayes_pls_golite062009
transmembrane receptor activity	1.14424818451335	bayes_pls_golite062009
signal transducer activity	1.12659599250323	bayes_pls_golite062009
molecular transducer activity	1.12659599250323	bayes_pls_golite062009
transmembrane transporter activity	1.07876412297114	bayes_pls_golite062009
receptor binding	1.0390886965673	bayes_pls_golite062009
polysaccharide binding	0.99559313679422	bayes_pls_golite062009
type 2 angiotensin receptor binding	0.92552398196189	bayes_pls_golite062009
collagen binding	0.307023895861541	bayes_pls_golite062009
active transmembrane transporter activity	0.262958899612658	bayes_pls_golite062009
growth factor activity	0.21183671094477	bayes_pls_golite062009

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..411]	PSI-BLAST	91.09691	Plasminogen activator inhibitor-2

Protein Overview: Spn4-PF, Spn4-PE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: