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Protein Overview: Taf1-PB

General Information:
Name(s) found: Taf1-PB / FBpp0089369 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene TBP-associated factor 1 is referred to in FlyBase by the symbol Dmel\Taf1 (CG17603, FBgn0010355). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2472611..2481770. It has the cytological map location 84A1. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding; histone serine kinase activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of transcription from RNA polymerase II promoter; regulation of transcription involved in G2/M-phase of mitotic cell cycle; histone acetylation. 28 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; peripheral nervous system; nervous system; female germline cyst; external compound sense organ; adult segment; adult mesothoracic segment; thoracic segment; compound cell cluster organ; larva; gamete; integumentary plate. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2129 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    transcription factor TFIID complex [IPI][ISS][NAS]
    Biological Process: protein complex assembly [NAS]
    regulation of transcription, DNA-dependent [IEA][NAS]
    histone acetylation [IDA]
    regulation of transcription involved in G2/M-phase of mitotic cell cycle [IMP]
    regulation of cell cycle [NAS]
    positive regulation of transcription from RNA polymerase II promoter [IDA]
    transcription initiation from RNA polymerase II promoter [ISS]
    Molecular Function: DNA binding [NAS]
    zinc ion binding [IEA]
    histone serine kinase activity [IDA]
    general RNA polymerase II transcription factor activity [ISS]
    protein kinase activity [NAS]
    sequence-specific DNA binding [IDA]
    transcription activator activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEMESDNSDD EGSIGNGLDL TGILFGNIDS EGRLLQDDDG EGRGGTGFDA ELRENIGSLS  60
   61 KLGLDSMLLE VIDLKEAEPP SDDEEEEDAR PSAVSASEGM SAFDALKAGV KREDGAVKAQ 120
  121 DDAIDYSDIT ELSEDCPRTP PEETSTYDDL EDAIPASKVE AKLTKDDKEL MPPPSAPMRS 180
  181 GSGGGIEEPA KSNDASSPSD DSKSTDSKDA DRKLDTPLAD ILPSKYQNVD VRELFPDFRP 240
  241 QKVLRFSRLF GPGKPTSLPQ IWRHVRKRRR KRNQSRDQKT TNTGGSDSPS DTEEPRKRGF 300
  301 SLHYAAEPTP AECMSDDEDK LLGDFNSEDV RPEGPDNGEN SDQKPKVADW RFGPAQIWYD 360
  361 MLEVPDSGEG FNYGFKTKAA STSSQPQLKD ERRVKSPEDD VEDPSIADDA FLMVSQLHWE 420
  421 DDVVWDGNDI KAKVLQKLNS KTNAAGWLPS SGSRTAGAFS QPGKPSMPVG SGSSKQGSGA 480
  481 SSKKAQQNAQ AKPAEAPDDT WYSLFPVENE ELIYYKWEDE VIWDAQQVSK VPKPKVLTLD 540
  541 PNDENIILGI PDDIDPSKIN KSTGPPPKIK IPHPHVKKSK ILLGKAGVIN VLAEDTPPPP 600
  601 PKSPDRDPFN ISNDTYYTPK TEPTLRLKVG GNLIQHSTPV VELRAPFVPT HMGPMKLRAF 660
  661 HRPPLKKYSH GPMAQSIPHP VFPLLKTIAK KAKQREVERI ASGGGDVFFM RNPEDLSGRD 720
  721 GDIVLAEFCE EHPPLINQVG MCSKIKNYYK RKAEKDSGPQ DFVYGEVAFA HTSPFLGILH 780
  781 PGQCIQAIEN NMYRAPIYPH KMAHNDFLVI RTRNNYWIRS VNSIYTVGQE CPLYEVPGPN 840
  841 SKRANNFTRD FLQVFIYRLF WKSRDNPRRI RMDDIKQAFP AHSESSIRKR LKQCADFKRT 900
  901 GMDSNWWVIK PEFRLPSEEE IRAMVSPEQC CAYFSMIAAE QRLKDAGYGE KFLFAPQEDD 960
  961 DEEAQLKLDD EVKVAPWNTT RAYIQAMRGK CLLQLSGPAD PTGCGEGFSY VRVPNKPTQT1020
 1021 KEEQESQPKR SVTGTDADLR RLPLQRAKEL LRQFKVPEEE IKKLSRWEVI DVVRTLSTEK1080
 1081 AKAGEEGMDK FSRGNRFSIA EHQERYKEEC QRIFDLQNRV LASSEVLSTD EAESSASEES1140
 1141 DLEELGKNLE NMLSNKKTST QLSREREELE RQELLRQLDE EHGGPSGSGG AKGAKGKDDP1200
 1201 GQQMLATNNQ GRILRITRTF RGNDGKEYTR VETVRRQPVI DAYIKIRTTK DEQFIKQFAT1260
 1261 LDEQQKEEMK REKRRIQEQL RRIKRNQERE RLAQLAQNQK LQPGGMPTSL GDPKSSGGHS1320
 1321 HKERDSGYKE VSPSRKKFKL KPDLKLKCGA CGQVGHMRTN KACPLYSGMQ SSLSQSNPSL1380
 1381 ADDFDEQSEK EMTMDDDDLV NVDGTKVTLS SKILKRHGGD DGKRRSGSSS GFTLKVPRDA1440
 1441 MGKKKRRVGG DLHCDYLQRH NKTANRRRTD PVVVLSSILE IIHNELRSMP DVSPFLFPVS1500
 1501 AKKVPDYYRV VTKPMDLQTM REYIRQRRYT SREMFLEDLK QIVDNSLIYN GPQSAYTLAA1560
 1561 QRMFSSCFEL LAEREDKLMR LEKAINPLLD DDDQVALSFI FDKLHSQIKQ LPESWPFLKP1620
 1621 VNKKQVKDYY TVIKRPMDLE TIGKNIEAHR YHSRAEYLAD IELIATNCEQ YNGSDTRYTK1680
 1681 FSKKILEYAQ TQLIEFSEHC GQLENNIAKT QERARENAPE FDEAWGNDDY NFDRGSRASS1740
 1741 PGDDYIDVEG HGGHASSSNS IHRSMGAEAG SSHTAPAVRK PAPPGPGEVK RGRGRPRKQR1800
 1801 DPVEEVKSQN PVKRGRGRPR KDSLASNMSH TQAYFLDEDL QCSTDDEDDD EEEDFQEVSE1860
 1861 DENNAASILD QGERINAPAD AMDGMFDPKN IKTEIDLEAH QMAEEPIGED DSQQVAEAMV1920
 1921 QLSGVGGYYA QQQQDESMDV DPNYDPSDFL AMHKQRQSLG EPSSLQGAFT NFLSHEQDDN1980
 1981 GPYNPAEAST SAASGADLGM DASMAMQMAP EMPVNTMNNG MGIDDDLDIS ESDEEDDGSR2040
 2041 VRIKKEVFDD GDYALQHQQM GQAASQSQIY MVDSSNEPTT LDYQQPPQLD FQQVQEMEQL2100
 2101 QHQVMPPMQS EQLQQQQTPQ GDNDYAWTF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..135] PSI-BLAST 22.09691 TAF(II)230 TBP-binding fragment
    2 View Details [136..188] deduced N/A No confident structure predictions are available.
    3 View Details [189..389] MSA 1.020949 View MSA. No confident structure predictions are available.
    4 View Details [390..470] deduced N/A No confident structure predictions are available.
    5 View Details [471..534] deduced N/A No confident structure predictions are available.
    6 View Details [535..622] deduced N/A No confident structure predictions are available.
    7 View Details [623..880] deduced N/A No confident structure predictions are available.
    8 View Details [881..1336] PSI-BLAST 4.522879 alpha-actinin
    9 View Details [1337..1400] deduced N/A No confident structure predictions are available.
    10 View Details [1401..1724] PSI-BLAST 49.045757 TAFII250 double bromodomain module
    11 View Details [1725..1814] deduced N/A No confident structure predictions are available.
    12 View Details [1815..2016] MSA 1.242988 View MSA. No confident structure predictions are available.
    13 View Details [2017..2129] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.1249176514747 bayes_pls_golite062009
  • protein binding
    		•  3.02658853804606 bayes_pls_golite062009
  • binding
    		•  3.02588173330447 bayes_pls_golite062009
  • actin binding
    		•  2.99249761866244 bayes_pls_golite062009
  • actin filament binding
    		•  2.67692481578399 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.44577095508006 bayes_pls_golite062009
  • transcription activator activity
    		•  2.01637187744715 bayes_pls_golite062009
  • protein complex binding
    		•  1.83007463428411 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.17938200837598 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.909550969508159 bayes_pls_golite062009
  • identical protein binding
    		•  0.650360032617391 bayes_pls_golite062009
  • structural molecule activity
    		•  0.565745818602161 bayes_pls_golite062009
  • transcription factor binding
    		•  0.563443610763849 bayes_pls_golite062009
  • receptor binding
    		•  0.344679796081435 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.32199002401243 bayes_pls_golite062009
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.
    13 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle