Protein Overview: mib1-PA

General Information:
Name(s) found:	mib1-PA / FBpp0075275 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|68565370\|sp\|Q9VUX2.3\|MIB_DROME RecName: Full=E3 ubiquitin-protein ligase mind-bomb; AltName: Full=Mind bomb homolog; Short=D-mib [NCBI NR] gi\|45550629\|ref\|NP_648826.2\| mind bomb 1 [Drosophila melanogaster] [NCBI NR] gi\|45445872\|gb\|AAF49551.3\| mind bomb 1 [Drosophila melanogaster] [NCBI NR] gi\|21428712\|gb\|AAM50016.1\| SD05267p [Drosophila melanogaster] [NCBI NR] E3 ubiquitin-protein ligase mind-bomb OS=Drosophila melanogaster GN=mib1 PE=1 SV=3 [Swiss-Prot] The gene mind bomb 1 is referred to in FlyBase by the symbol Dmel\mib1 (CG5841, FBgn0036558). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:15999652..16004912. It has the cytological map location 72C2. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: protein localization; endocytosis; sensory organ development; lateral inhibition; regulation of Notch signaling pathway; Notch signaling pathway; positive regulation of Notch signaling pathway; imaginal disc-derived wing morphogenesis; imaginal disc-derived leg morphogenesis; compound eye morphogenesis. 20 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: adult segment; organ system; adult mesothoracic segment; thoracic segment; peripheral nervous system; nervous system; adult; imaginal precursor; embryonic nervous system; dorsal thoracic disc; external compound sense organ. It has one annotated transcript and one annotated polypeptide. [FlyBase] (AAF49551) CG5841-PA [DrosMelano7227.FASTAC.txt] CG5841-PA [Drosophila melanogaster]gi\|21428712\|gb\|AAM50016.1\| SD05267p [Drosophila melanogaster]gi\|45550629\|ref\|NP_648826.2\| CG5841-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=3L:complement(15999833..15999973,16000033..16001970,16002030..16003262,16004380..16004748); ID=FBpp0075275; name=mib1-PA; parent=FBgn0036558,FBtr0075520; dbxref=GB_protein:AAF49551.2,FlyBase:FBpp0075275,FlyBase_Annotation_IDs:CG5841-PA,G [fly-100309-contam.fasta] Ubiquitin ligase protein mind-bomb (Mind bomb homolog) (D-mib) [nr-271106-contam.fasta] CG5841-PA [Drosophila melanogaster] [nr-271106-contam.fasta] mind bomb 1 CG5841-PA [Drosophila melanogaster] [nr-271106-contam.fasta] SD05267p [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3L:complement(15999833..15999973,16000033..16001970,16002030..16003262,16004380..16004748); ID=FBpp0075275; name=mib1-PA; parent=FBgn0036558,FBtr0075520; dbxref=GB_protein:AAF49551.2,FlyBase:FBpp0075275,FlyBase_Annotation_IDs:CG5841-PA,GB_protein:AAF49551.3,REFSEQ:NP_648826,GB_protein:AAF49551; MD5=219b57c735646da1fce9890882192514; length=1226; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3L:complement(15999833..15999973,16000033..16001970,16002030..16003262,16004380..16004748); ID=FBpp0075275; name=mib1-PA; parent=FBgn0036558,FBtr0075520; dbxref=GB_protein:AAF49551.2,FlyBase:FBpp0075275,FlyBase_Annotation_IDs:CG5841-PA,GB_protein:AAF49551.3,REFSEQ:NP_648826,GB_protein:AAF49551; MD5=219b57c735646da1fce9890882192514; length=1226; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=3L:complement(15999833..15999973,16000033..16001970,16002030..16003262,16004380..16004748); ID=FBpp0075275; name=mib1-PA; parent=FBgn0263601,FBtr0075520; dbxref=GB_protein:AAF49551.2,FlyBase:FBpp0075275,FlyBase_Annotation_IDs:CG5841-PA,GB_protein:AAF49551.3,REFSEQ:NP_648826,GB_protein:AAF49551,FlyMine:FBpp0075275,modMine:FBpp0075275; MD5=219b57c735646da1fce9890882192514; length=1226; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3L:complement(join(16011280..16011648,16008930..16010162,16006933..16008870,16006733..16006873)); ID=FBpp0075275; name=mib1-PA; parent=FBgn0263601,FBtr0075520; dbxref=GB_protein:AAF49551.2,FlyBase:FBpp0075275,FlyBase_Annotation_IDs:CG5841-PA,GB_protein:AAF49551.3,REFSEQ:NP_648826,GB_protein:AAF49551,FlyMine:FBpp0075275,modMine:FBpp0075275; MD5=219b57c735646da1fce9890882192514; length=1226; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3L:complement(join(16011280..16011648,16008930..16010162,16006933..16008870,16006733..16006873)); ID=FBpp0075275; name=mib1-PA; parent=FBgn0263601,FBtr0075520; dbxref=GB_protein:AAF49551.2,FlyBase:FBpp0075275,FlyBase_Annotation_IDs:CG5841-PA,GB_protein:AAF49551.3,REFSEQ:NP_648826,GB_protein:AAF49551,FlyMine:FBpp0075275,modMine:FBpp0075275; MD5=219b57c735646da1fce9890882192514; length=1226; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0075275 type=protein; loc=3L:complement(join(16011280..16011648,16008930..16010162,16006933..16008870,16006733..16006873)); ID=FBpp0075275; name=mib1-PA; parent=FBgn0263601,FBtr0075520; dbxref=GB_protein:AAF49551.2,FlyBase:FBpp0075275,FlyBase_Annotation_IDs:CG5841-PA,GB_protein:AAF49551.3,REFSEQ:NP_648826,GB_protein:AAF49551,FlyMine:FBpp0075275,modMine:FBpp0075275; MD5=219b57c735646da1fce9890882192514; length=1226; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3L:complement(join(16011280..16011648,16008930..16010162,16006933..16008870,16006733..16006873)); ID=FBpp0075275; name=mib1-PA; parent=FBgn0263601,FBtr0075520; dbxref=GB_protein:AAF49551.2,FlyBase:FBpp0075275,FlyBase_Annotation_IDs:CG5841-PA,GB_protein:AAF49551.3,REFSEQ:NP_648826,GB_protein:AAF49551,UniProt/Swiss-Prot:Q9VUX2,FlyMine:FBpp0075275,modMine:FBpp0075275; MD5=219b57c735646da1fce9890882192514; length=1226; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1226 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA] apical cortex [IDA]
Biological Process:	imaginal disc-derived leg morphogenesis [IMP] positive regulation of endocytosis [NAS] regulation of Notch signaling pathway [IMP] protein localization [IMP] imaginal disc-derived wing morphogenesis [IMP] imaginal disc-derived wing margin morphogenesis [NAS] endocytosis [IMP] compound eye development [NAS] positive regulation of Notch signaling pathway [IMP] sensory organ development [IMP] Notch signaling pathway [IMP] compound eye morphogenesis [IMP] lateral inhibition [IMP] protein ubiquitination [IEA][NAS]
Molecular Function:	ubiquitin-protein ligase activity [IEA][NAS] zinc ion binding [IEA] protein binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSCAATLSSA KDSTNANASG GGGGGGGGGA PTNSNTNTNT NTQSTAVGVV VSSAAGTGVG  60
   61 VGGGGGGGGS LPGGTTSSSS ASAAGGVAAG GGGNSAAALV RRFSMEGVGA RVIRGPDWKW 120
  121 NKQDGGEGHV GTVRNFESAE EVVVVWDNGT AANYRCAGAY DLRILDSAPT GVKHEGTMCD 180
  181 TCRQQPIFGI RWKCAECINY DLCSICYHGD KHHLRHRFYR ITTPGGERTM LEPRRKSKKV 240
  241 LARGIFPGAR VVRGVDWQWE DQDGGVGRRG KVNEIQDWSS ASPRSAAYVI WDNGSKNLYR 300
  301 VGFEGMADLK VVNDAKGSNV YRDHLPLLGE NGPGKGPHGF QIGDKVTVDL DLEIVQSLQH 360
  361 GHGGWTDGMF ECLSNAGMVV GIDEDHDIVV AYNSGNRWTF NPAVLTKVSS PTTAPPEFQV 420
  421 GDIVKICSDV ESIKILQRGH GEWADAMQLT LGKIGRVQQV YHDNDLKVEV GNTSWTYNPL 480
  481 AVCKVASSTA SDGSCAPVIP SSERLSAILK KLFEPNVSGD ATEEFVKAAA NGFAARCEEY 540
  541 LAGAAQPSTS SASPSSGPDV NVNGVFAGHT ALQAASQNGH IEVIQVLLRH AVDVEIEDKD 600
  601 GDRAVHHAAF GDEAAVIEIL AKAGADLNAR NKRRQTSLHI AVNKGHLNVV KTLLTLGCHP 660
  661 SLQDSEGDTP LHDAISKEHD EMLSLLLDFG ADITLNNNNG FNALHHAALK GNPSAMKILL 720
  721 TKTNRPWIVE EKKDDGYTAL HLAALNNHVE IAELLVHMGK ANMDRQNVNL QTALHLAVER 780
  781 QHVQIVKLLV QDGADLNIPD KDGDTPLHEA LRHHTLSQLK QLQDVEGFGK LLMGLRNANN 840
  841 KKASASIACF LAANGADLTL KNRKQQTPLD LCPDPNLCKT LVKCYNERKT DDSELPGNVA 900
  901 GTSSSARARA ASGSLNQSSS VNMPLSSLAA SSTFPAASSS SIFALNGIAN EMSQSLHEDP 960
  961 PKSSASLDEC LVCSDAKRDT VFKPCGHVSC CETCAPRVKK CLICRETVSS REKIDECLVC1020
 1021 SDRRAAVFFR PCGHMVACEH CSALMKKCVL CRTQIDEILS FSLCCGGSGR PEKVSVAAGA1080
 1081 MATVGLPLPD DRFMEAAAAA ACANASGHSV AMNNTVVTPV AGSSNQLNSQ NNLLAAAAAS1140
 1141 SNVSNLSAAG NAMVAPSNVN NFQMDDVQKL KQQLQDIKEQ TMCPVCFDRI KNMVFLCGHG1200
 1201 TCQMCGDQIE GCPICRKTVE KRILLF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.60

Protein Overview: mib1-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: