Protein Overview: msn-PE

General Information:
Name(s) found:	msn-PE / FBpp0089313 [FlyBase]
Description(s) found: Found 11 descriptions. SHOW ALL	The gene misshapen is referred to in FlyBase by the symbol Dmel\msn (CG16973, FBgn0010909). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:2555775..2586540. It has the cytological map location 62E6-62E7. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine kinase activity; MAP kinase kinase kinase kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; regulation of embryonic cell shape; dorsal closure; optic lobe placode development; JNK cascade; imaginal disc fusion, thorax closure; photoreceptor cell morphogenesis; nuclear migration. 40 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: nervous system; multi-cell-component structure; peripheral nervous system; adult segment; organ system; external compound sense organ; cell projection; imaginal precursor; adult brain; compound cell cluster organ; rhabdomere; wing hair; primordium; axon. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1042 amino acids
Gene Ontology:
Cellular Component:	cell cortex [IDA]
Biological Process:	regulation of cell shape [IMP] dorsal closure [IGI][IMP][TAS] imaginal disc fusion, thorax closure [IMP] activation of MAPKKK activity [NAS] oogenesis [NAS] photoreceptor cell morphogenesis [IMP] establishment of planar polarity [NAS] nuclear migration [IMP] optic lobe placode development [IMP] JNK cascade [IGI][IMP][ISS][NAS] protein amino acid phosphorylation [ISS][NAS] regulation of embryonic cell shape [IMP]
Molecular Function:	ATP binding [IEA] receptor signaling protein serine/threonine kinase activity [NAS] small GTPase regulator activity [IEA] protein serine/threonine kinase activity [ISS][NAS] MAP kinase kinase kinase kinase activity [ISS][NAS] JUN kinase kinase kinase kinase activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAHQQQQQLA PSVNCSLDDI DLTALKDPAG IFELIEVVGN GTYGQVYKGR HTKTGQLAAI  60
   61 KVMDVTEDEE EEIKLEINVL KKYSNHRNIA TYYGAFIKKS PPGKDDQLWL VMEYCGAGSV 120
  121 TDLVKSTKGQ SLKEEWIAYI CREILRGLSY LHSNKVIHRD IKGQNVLLTD NAEVKLVDFG 180
  181 VSAQLDRTIG RRNTFIGTPY WMAPEVIACD ENPDATYDNR SDLWSLGITA LEMAESQPPL 240
  241 CDLHPMRALF LIPRNSPPRL KSKKWSKKFH GFIDTVLVKD YHQRPYTENL LKHGFIKDQP 300
  301 TDRQVRIQLK DHIDRCKKRK QEKEREDYRY SGSDNDDDEP QLAGEHSSIV QAPGGDTLRR 360
  361 NFQQIQEGRL AAEQQQQHHL MAQAQAQAAA AHAAAQAQAQ LQQQQQQAAA AAAAAAHAAQ 420
  421 QAQQAAQQAQ AQQPQANRQP KPPSRQQVEE PGPPARPPQR LIVVPDPPHA NRPLPPTPKC 480
  481 GEPAGQTPQQ QQRNSQNNFK PSLPPRRPED HLDVLAAQLS ELGVVFSQQP QPQTAAGGQG 540
  541 SQQQAQPEAP PRNNRQSSGL SSSGGSASGG GGSSKPAAAL PQQSNNHLGQ PVNPLDPLDS 600
  601 SDSDSEPDEP NDRARNDGTL LASDPPKPLP GLGPVSEDAN TTTPLSHGSG GPPNRPLPPT 660
  661 PDDDDQAGDR TLIMKRKQRS FLTFGFGAGG SGPSRRESHV NVNVTPTSHE AANDTPEIRK 720
  721 YKKRFNSEIL CAALWGVNLL IGTENGLMLL DRSGQGKVYQ LISRRRFQQM EVLEGQNILV 780
  781 TISGKKNRVR VYYLSWLKSK ILRTDGLSDQ VERRNGWINV GDLQGAVHFK IVKYERIKFL 840
  841 VIALKDSIEI YAWAPKPYHK FMAFKNFGEL EHRPLLVDLT IEDQSRLKVI YGSAEGFHAV 900
  901 DLDSAEVYDI YLPKHTQGAI IPHCIVALPN SNGMQLLLCY DNEGVYVNTV GRVSKNIVLQ 960
  961 WGEMPTSVAY IGTGQIMGWG NKAIEIRSVE SGHLDGVFMH KKAQRLKFLC ERNDKVFFSS1020
 1021 AKGASSCQIY FMTLNKPGMA NW

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: msn-PE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: