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Protein Overview: msn-PA

General Information:
Name(s) found: msn-PA / FBpp0072830 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene misshapen is referred to in FlyBase by the symbol Dmel\msn (CG16973, FBgn0010909). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:2555775..2586540. It has the cytological map location 62E6-62E7. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine kinase activity; MAP kinase kinase kinase kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; regulation of embryonic cell shape; dorsal closure; optic lobe placode development; JNK cascade; imaginal disc fusion, thorax closure; photoreceptor cell morphogenesis; nuclear migration. 40 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: nervous system; multi-cell-component structure; peripheral nervous system; adult segment; organ system; external compound sense organ; cell projection; imaginal precursor; adult brain; compound cell cluster organ; rhabdomere; wing hair; primordium; axon. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1504 amino acids

    Gene Ontology:
    Cellular Component: cell cortex [IDA]
    Biological Process: regulation of cell shape [IMP]
    dorsal closure [IGI][IMP][TAS]
    imaginal disc fusion, thorax closure [IMP]
    activation of MAPKKK activity [NAS]
    oogenesis [NAS]
    photoreceptor cell morphogenesis [IMP]
    establishment of planar polarity [NAS]
    nuclear migration [IMP]
    optic lobe placode development [IMP]
    JNK cascade [IGI][IMP][ISS][NAS]
    protein amino acid phosphorylation [ISS][NAS]
    regulation of embryonic cell shape [IMP]
    Molecular Function: ATP binding [IEA]
    receptor signaling protein serine/threonine kinase activity [NAS]
    small GTPase regulator activity [IEA]
    protein serine/threonine kinase activity [ISS][NAS]
    MAP kinase kinase kinase kinase activity [ISS][NAS]
    JUN kinase kinase kinase kinase activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAHQQQQQLA PSVNCSLDDI DLTALKDPAG IFELIEVVGN GTYGQVYKGR HTKTGQLAAI  60
   61 KVMDVTEDEE EEIKLEINVL KKYSNHRNIA TYYGAFIKKS PPGKDDQLWL VMEYCGAGSV 120
  121 TDLVKSTKGQ SLKEEWIAYI CREILRGLSY LHSNKVIHRD IKGQNVLLTD NAEVKLVDFG 180
  181 VSAQLDRTIG RRNTFIGTPY WMAPEVIACD ENPDATYDNR SDLWSLGITA LEMAESQPPL 240
  241 CDLHPMRALF LIPRNSPPRL KSKKWSKKFH GFIDTVLVKD YHQRPYTENL LKHGFIKDQP 300
  301 TDRQVRIQLK DHIDRCKKRK QEKEREDYRY SGSDNDDDEP QLAGEHSSIV QAPGGDTLRR 360
  361 NFQQIQEGRL AAEQQQQHHL MAQAQAQAAA AHAAAQAQAQ LQQQQQQAAA AAAAAAHAAQ 420
  421 QAQQAAQQAQ AQQPQANRQP KPPSRQQVEE PGPPARPPQR LIVVPDPPHA NRPLPPTPKC 480
  481 GEPAGQTPQQ QQRNSQNNFK PSLPPRRPEP QPQTAAGGQG SQQQAQPEAP PRNNRQSSGL 540
  541 SSSGGSASGG GGSSKPAAAL PQQSNNHLGQ PVNPLDPLDS SDSDSEPDEP NDRARNDGTL 600
  601 LASDPPKPLP GLGPVSEDAN TTTPLSHGSG GPPNRPLPPT PDDDDQAGDR TLIMKRKLEQ 660
  661 NINRLQKSAS TSQANVTPSR RGDESNLLRD WDFDRFFPKN ANGPRGSGRG SPTTTASLSR 720
  721 SSQLSTLKVD TKLQRASVAE AITRPVPRGY QPLKAEPSAS QSIAKEQGSA SGSGSGSGSA 780
  781 SGSGSGGSTN SPAHKRQDSD SRLPTNFERG FRRENSDFFP LAKRYSAVFS GASASGSTAG 840
  841 SPSAQALQRS SAVYQRNSIY SSSISSKSKE NDVPGAPGAA AAGTATASAK PGPAAATTTA 900
  901 TKGAAPKTSK SLANFHFLRP RREKTESVIV LQNAAVRAQR LQQLQQQQQQ QQLQQQQQQQ 960
  961 NRGGGGGGGG GGGGGGSSGV GADGTGLGTP GTRTSSVLPD LLSQASPATP PRHDKSSSEE1020
 1021 YQAAISSSVH STPSKSFIAS SGSGGLGLGG GTVVGGVIIS SNHSPQSTIS LASSSSNSRQ1080
 1081 NSPKNSISKT RSSSSITNLL HKSASSSSAN LHHLTPCSST SSASISNPLP PHAYALQQKQ1140
 1141 RSFLTFGFGA GGSGPSRRES HVNVNVTPTS HEAANDTPEI RKYKKRFNSE ILCAALWGVN1200
 1201 LLIGTENGLM LLDRSGQGKV YQLISRRRFQ QMEVLEGQNI LVTISGKKNR VRVYYLSWLK1260
 1261 SKILRTDGLS DQVERRNGWI NVGDLQGAVH FKIVKYERIK FLVIALKDSI EIYAWAPKPY1320
 1321 HKFMAFKNFG ELEHRPLLVD LTIEDQSRLK VIYGSAEGFH AVDLDSAEVY DIYLPKHTQG1380
 1381 AIIPHCIVAL PNSNGMQLLL CYDNEGVYVN TVGRVSKNIV LQWGEMPTSV AYIGTGQIMG1440
 1441 WGNKAIEIRS VESGHLDGVF MHKKAQRLKF LCERNDKVFF SSAKGASSCQ IYFMTLNKPG1500
 1501 MANW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.54

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle