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Protein Overview: dnc-PG

General Information:
Name(s) found: dnc-PG / FBpp0070496 [FlyBase]
Description(s) found:
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  • gi|45551406|ref|NP_726858.2| dunce, isoform G [Drosophila melanogaster] [NCBI NR]
  • gi|45446801|gb|AAN09605.2| dunce, isoform G [Drosophila melanogaster] [NCBI NR]
  • The gene dunce is referred to in FlyBase by the symbol Dmel\dnc (CG32498, FBgn0000479). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:3070475..3233360. It has the cytological map location 3C9-3D1. Based on sequence similarity, it is predicted to have molecular function</span>: 3',5'-cyclic-AMP phosphodiesterase activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; conditioned taste aversion; short-term memory; axon extension. 72 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: anatomical structure; organ system; embryonic neuron; embryonic nervous system; female germline cyst; nervous system; developing anatomical structure; egg; multi-cell-component structure; synapse; postsynaptic membrane; adult brain; neuromuscular junction. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase]
  • (AAN09605) CG32498-PG [DrosMelano7227.FASTAC.txt]
  • CG32498-PG, isoform G [Drosophila melanogaster]gi|45551406|ref|NP_726858.2| CG32498-PG [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:join(3208217..3208641,3215074..3215250,3226475..3226579,3228178..3228364,3228588..3228681,3231275..3231615,3231722..3231986,3232059..3232173,3232248..3232410,3232481..3232849,3233003..3233206); ID=FBpp0070496; name=dnc-PG; parent=FBgn0 [fly-100309-contam.fasta]
  • dunce CG32498-PG, isoform G [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG32498-PG, isoform G [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:join(3208217..3208641,3215074..3215250,3226475..3226579,3228178..3228364,3228588..3228681,3231275..3231615,3231722..3231986,3232059..3232173,3232248..3232410,3232481..3232849,3233003..3233206); ID=FBpp0070496; name=dnc-PG; parent=FBgn0000479,FBtr0070520; dbxref=GB_protein:AAN09605.2,GB_protein:AAN09605.1,FlyBase:FBpp0070496,FlyBase_Annotation_IDs:CG32498-PG,REFSEQ:NP_726858,GB_protein:AAN09605; MD5=42815e9f319db2c3bc615c3835a50ba7; length=814; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(3208217..3208641,3215074..3215250,3226475..3226579,3228178..3228364,3228588..3228681,3231275..3231615,3231722..3231986,3232059..3232173,3232248..3232410,3232481..3232849,3233003..3233206); ID=FBpp0070496; name=dnc-PG; parent=FBgn0000479,FBtr0070520; dbxref=GB_protein:AAN09605.2,GB_protein:AAN09605.1,FlyBase:FBpp0070496,FlyBase_Annotation_IDs:CG32498-PG,REFSEQ:NP_726858,GB_protein:AAN09605; MD5=42815e9f319db2c3bc615c3835a50ba7; length=814; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Isoform G of cAMP-specific 3',5'-cyclic phosphodiesterase, isoforms N/G OS=Drosophila melanogaster GN=dnc [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:join(3208217..3208641,3215074..3215250,3226475..3226579,3228178..3228364,3228588..3228681,3231275..3231615,3231722..3231986,3232059..3232173,3232248..3232410,3232481..3232849,3233003..3233206); ID=FBpp0070496; name=dnc-PG; parent=FBgn0000479,FBtr0070520; dbxref=GB_protein:AAN09605.2,GB_protein:AAN09605.1,FlyBase:FBpp0070496,FlyBase_Annotation_IDs:CG32498-PG,REFSEQ:NP_726858,GB_protein:AAN09605,FlyMine:FBpp0070496,modMine:FBpp0070496; MD5=42815e9f319db2c3bc615c3835a50ba7; length=814; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:join(3314184..3314608,3321041..3321217,3332442..3332546,3334145..3334331,3334555..3334648,3337242..3337582,3337689..3337953,3338026..3338140,3338215..3338377,3338448..3338816,3338970..3339173); ID=FBpp0070496; name=dnc-PG; parent=FBgn0000479,FBtr0070520; dbxref=GB_protein:AAN09605.2,GB_protein:AAN09605.1,FlyBase:FBpp0070496,FlyBase_Annotation_IDs:CG32498-PG,REFSEQ:NP_726858,GB_protein:AAN09605,FlyMine:FBpp0070496,modMine:FBpp0070496; MD5=42815e9f319db2c3bc615c3835a50ba7; length=814; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(3314184..3314608,3321041..3321217,3332442..3332546,3334145..3334331,3334555..3334648,3337242..3337582,3337689..3337953,3338026..3338140,3338215..3338377,3338448..3338816,3338970..3339173); ID=FBpp0070496; name=dnc-PG; parent=FBgn0000479,FBtr0070520; dbxref=GB_protein:AAN09605.2,GB_protein:AAN09605.1,FlyBase:FBpp0070496,FlyBase_Annotation_IDs:CG32498-PG,REFSEQ:NP_726858,GB_protein:AAN09605,FlyMine:FBpp0070496,modMine:FBpp0070496; MD5=42815e9f319db2c3bc615c3835a50ba7; length=814; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q9W4T4, Isoform G of cAMP-specific 3',5'-cyclic phosphodiesterase, isoforms N/G OS=Drosophila melanogaster GN=dnc [DROME.fasta.20160308]
  • FBpp0070496 type=protein; loc=X:join(3314184..3314608,3321041..3321217,3332442..3332546,3334145..3334331,3334555..3334648,3337242..3337582,3337689..3337953,3338026..3338140,3338215..3338377,3338448..3338816,3338970..3339173); ID=FBpp0070496; name=dnc-PG; parent=FBgn0000479,FBtr0070520; dbxref=GB_protein:AAN09605.2,GB_protein:AAN09605.1,FlyBase:FBpp0070496,FlyBase_Annotation_IDs:CG32498-PG,REFSEQ:NP_726858,GB_protein:AAN09605,FlyMine:FBpp0070496,modMine:FBpp0070496; MD5=42815e9f319db2c3bc615c3835a50ba7; length=814; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:join(3314184..3314608,3321041..3321217,3332442..3332546,3334145..3334331,3334555..3334648,3337242..3337582,3337689..3337953,3338026..3338140,3338215..3338377,3338448..3338816,3338970..3339173); ID=FBpp0070496; name=dnc-PG; parent=FBgn0000479,FBtr0070520; dbxref=GB_protein:AAN09605.2,GB_protein:AAN09605.1,FlyBase:FBpp0070496,FlyBase_Annotation_IDs:CG32498-PG,REFSEQ:NP_726858,GB_protein:AAN09605,FlyMine:FBpp0070496,modMine:FBpp0070496; MD5=42815e9f319db2c3bc615c3835a50ba7; length=814; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 814 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATEAEGEEF DVDPMDEDDE DQTYDRETEE FYSNIQDAAG TGSSSRSKRS SLFSRSDSSA  60
   61 TTTSSSGGGT FTGGKRRSAA SILSSSMCSD LMTSDRRSST ATEYSVKSVT TGNTSQRRSS 120
  121 GRIRRYVSRM TIAGARRRTT GSFDVENGQG ARSPLEGGSP SAGLVLQNLP QRRESFLYRS 180
  181 DSDFEMSPKS MSRNSSIASE SHGEDLIVTP FAQILASLRS VRNNLLSLTN VPASNKSRRP 240
  241 NQSSSASRSG NPPGAPLSQG EEAYTRLATD TIEELDWCLD QLETIQTHRS VSDMASLKFK 300
  301 RMLNKELSHF SESSRSGNQI SEYICSTFLD KQQEFDLPSL RVEDNPELVA ANAAAGQQSA 360
  361 GQYARSRSPR GPPMSQISGV KRPLSHTNSF TGERLPTFGV ETPRENELGT LLGELDTWGI 420
  421 QIFSIGEFSV NRPLTCVAYT IFQSRELLTS LMIPPKTFLN FMSTLEDHYV KDNPFHNSLH 480
  481 AADVTQSTNV LLNTPALEGV FTPLEVGGAL FAACIHDVDH PGLTNQFLVN SSSELALMYN 540
  541 DESVLENHHL AVAFKLLQNQ GCDIFCNMQK KQRQTLRKMV IDIVLSTDMS KHMSLLADLK 600
  601 TMVETKKVAG SGVLLLDNYT DRIQVLENLV HCADLSNPTK PLPLYKRWVA LLMEEFFLQG 660
  661 DKERESGMDI SPMCDRHNAT IEKSQVGFID YIVHPLWETW ADLVHPDAQD ILDTLEENRD 720
  721 YYQSMIPPSP PPSGVDENPQ EDRIRFQVTL EESDQENLAE LEEGDESGGE STTTGTTGTT 780
  781 AASALSGAGG GGGGGGGMAP RTGGCQNQPQ HGGM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..97] MSA 1.082983 View MSA. No confident structure predictions are available.
    2 View Details [98..265] MSA 6.145997 View MSA. No confident structure predictions are available.
    3 View Details [266..383] MSA 1.200989 View MSA. No confident structure predictions are available.
    4 View Details [384..814] PSI-BLAST 136.0 No description for 2fm0A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • cyclic-nucleotide phosphodiesterase activity
    		•  3.86434485322172 bayes_pls_golite062009
  • 3',5'-cyclic-nucleotide phosphodiesterase activity
    		•  3.8566356686502 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  3.16734214417311 bayes_pls_golite062009
  • 3',5'-cyclic-AMP phosphodiesterase activity
    		•  2.29938697204184 bayes_pls_golite062009
  • 3',5'-cyclic-GMP phosphodiesterase activity
    		•  2.29281173183086 bayes_pls_golite062009
  • catalytic activity
    		•  1.44092158711463 bayes_pls_golite062009
  • hydrolase activity
    		•  1.06080266556153 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.815214868148798 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.196287846714023 bayes_pls_golite062009
  • binding
    		•  0.0840884387362641 bayes_pls_golite062009
    4
    Term Confidence Notes
  • cyclic-nucleotide phosphodiesterase activity
    		•  3.86434485322172 bayes_pls_golite062009
  • 3',5'-cyclic-nucleotide phosphodiesterase activity
    		•  3.8566356686502 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  3.16734214417311 bayes_pls_golite062009
  • 3',5'-cyclic-AMP phosphodiesterase activity
    		•  2.29938697204184 bayes_pls_golite062009
  • 3',5'-cyclic-GMP phosphodiesterase activity
    		•  2.29281173183086 bayes_pls_golite062009
  • catalytic activity
    		•  1.44092158711463 bayes_pls_golite062009
  • hydrolase activity
    		•  1.06080266556153 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.815214868148798 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.196287846714023 bayes_pls_golite062009
  • binding
    		•  0.0840884387362641 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle