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Protein Overview: dnc-PD

General Information:
Name(s) found: dnc-PD / FBpp0070491 [FlyBase]
Description(s) found:
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  • gi|45551404|ref|NP_726852.2| dunce, isoform D [Drosophila melanogaster] [NCBI NR]
  • gi|45446800|gb|AAN09602.2| dunce, isoform D [Drosophila melanogaster] [NCBI NR]
  • The gene dunce is referred to in FlyBase by the symbol Dmel\dnc (CG32498, FBgn0000479). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:3070475..3233360. It has the cytological map location 3C9-3D1. Based on sequence similarity, it is predicted to have molecular function</span>: 3',5'-cyclic-AMP phosphodiesterase activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; conditioned taste aversion; short-term memory; axon extension. 72 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: anatomical structure; organ system; embryonic neuron; embryonic nervous system; female germline cyst; nervous system; developing anatomical structure; egg; multi-cell-component structure; synapse; postsynaptic membrane; adult brain; neuromuscular junction. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase]
  • (AAN09602) CG32498-PD [DrosMelano7227.FASTAC.txt]
  • CG32498-PD, isoform D [Drosophila melanogaster]gi|45551404|ref|NP_726852.2| CG32498-PD [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:join(3174035..3175188,3215074..3215250,3219960..3219998,3226475..3226579,3228184..3228364,3228588..3228681,3231275..3231615,3231722..3231986,3232059..3232173,3232248..3232410,3232481..3232849,3233003..3233206); ID=FBpp0070491; name=dnc [fly-100309-contam.fasta]
  • CG32498-PD, isoform D [Drosophila melanogaster] [nr-271106-contam.fasta]
  • dunce CG32498-PD, isoform D [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:join(3174035..3175188,3215074..3215250,3219960..3219998,3226475..3226579,3228184..3228364,3228588..3228681,3231275..3231615,3231722..3231986,3232059..3232173,3232248..3232410,3232481..3232849,3233003..3233206); ID=FBpp0070491; name=dnc-PD; parent=FBgn0000479,FBtr0070515; dbxref=GB_protein:AAN09602.2,GB_protein:AAN09602.1,FlyBase:FBpp0070491,FlyBase_Annotation_IDs:CG32498-PD,REFSEQ:NP_726852,GB_protein:AAN09602; MD5=1e47323df9e5f73cfd489205cdfcee9b; length=1068; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(3174035..3175188,3215074..3215250,3219960..3219998,3226475..3226579,3228184..3228364,3228588..3228681,3231275..3231615,3231722..3231986,3232059..3232173,3232248..3232410,3232481..3232849,3233003..3233206); ID=FBpp0070491; name=dnc-PD; parent=FBgn0000479,FBtr0070515; dbxref=GB_protein:AAN09602.2,GB_protein:AAN09602.1,FlyBase:FBpp0070491,FlyBase_Annotation_IDs:CG32498-PD,REFSEQ:NP_726852,GB_protein:AAN09602; MD5=1e47323df9e5f73cfd489205cdfcee9b; length=1068; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Isoform VI of cAMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila melanogaster GN=dnc [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:join(3174035..3175188,3215074..3215250,3219960..3219998,3226475..3226579,3228184..3228364,3228588..3228681,3231275..3231615,3231722..3231986,3232059..3232173,3232248..3232410,3232481..3232849,3233003..3233206); ID=FBpp0070491; name=dnc-PD; parent=FBgn0000479,FBtr0070515; dbxref=GB_protein:AAN09602.2,GB_protein:AAN09602.1,FlyBase:FBpp0070491,FlyBase_Annotation_IDs:CG32498-PD,REFSEQ:NP_726852,GB_protein:AAN09602,FlyMine:FBpp0070491,modMine:FBpp0070491; MD5=1e47323df9e5f73cfd489205cdfcee9b; length=1068; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:join(3280002..3281155,3321041..3321217,3325927..3325965,3332442..3332546,3334151..3334331,3334555..3334648,3337242..3337582,3337689..3337953,3338026..3338140,3338215..3338377,3338448..3338816,3338970..3339173); ID=FBpp0070491; name=dnc-PD; parent=FBgn0000479,FBtr0070515; dbxref=GB_protein:AAN09602.2,GB_protein:AAN09602.1,FlyBase:FBpp0070491,FlyBase_Annotation_IDs:CG32498-PD,REFSEQ:NP_726852,GB_protein:AAN09602,FlyMine:FBpp0070491,modMine:FBpp0070491; MD5=1e47323df9e5f73cfd489205cdfcee9b; length=1068; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(3280002..3281155,3321041..3321217,3325927..3325965,3332442..3332546,3334151..3334331,3334555..3334648,3337242..3337582,3337689..3337953,3338026..3338140,3338215..3338377,3338448..3338816,3338970..3339173); ID=FBpp0070491; name=dnc-PD; parent=FBgn0000479,FBtr0070515; dbxref=GB_protein:AAN09602.2,GB_protein:AAN09602.1,FlyBase:FBpp0070491,FlyBase_Annotation_IDs:CG32498-PD,REFSEQ:NP_726852,GB_protein:AAN09602,FlyMine:FBpp0070491,modMine:FBpp0070491; MD5=1e47323df9e5f73cfd489205cdfcee9b; length=1068; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q9W4T4, Isoform VI of cAMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila melanogaster GN=dnc [DROME.fasta.20160308]
  • FBpp0070491 type=protein; loc=X:join(3280002..3281155,3321041..3321217,3325927..3325965,3332442..3332546,3334151..3334331,3334555..3334648,3337242..3337582,3337689..3337953,3338026..3338140,3338215..3338377,3338448..3338816,3338970..3339173); ID=FBpp0070491; name=dnc-PD; parent=FBgn0000479,FBtr0070515; dbxref=GB_protein:AAN09602.2,GB_protein:AAN09602.1,FlyBase:FBpp0070491,FlyBase_Annotation_IDs:CG32498-PD,REFSEQ:NP_726852,GB_protein:AAN09602,FlyMine:FBpp0070491,modMine:FBpp0070491; MD5=1e47323df9e5f73cfd489205cdfcee9b; length=1068; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:join(3280002..3281155,3321041..3321217,3325927..3325965,3332442..3332546,3334151..3334331,3334555..3334648,3337242..3337582,3337689..3337953,3338026..3338140,3338215..3338377,3338448..3338816,3338970..3339173); ID=FBpp0070491; name=dnc-PD; parent=FBgn0000479,FBtr0070515; dbxref=GB_protein:AAN09602.2,GB_protein:AAN09602.1,FlyBase:FBpp0070491,FlyBase_Annotation_IDs:CG32498-PD,REFSEQ:NP_726852,GB_protein:AAN09602,FlyMine:FBpp0070491,modMine:FBpp0070491; MD5=1e47323df9e5f73cfd489205cdfcee9b; length=1068; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1068 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQESNGGPA AGGGAAAAPP PPPQYIITTP SEVDPDEVRS MADLELGSPE KQVQVQSQKF  60
   61 SSTSSTTKVA THSFSMSSSA GTTGQQSKQD SAQQIQQLQQ LQQLQQLQQQ QQQQQSQRII 120
  121 SSSTRSQSLQ SSTIVGEATT ITSGAAQILS ASAAASLAQQ LKAQSSTSII TSSEQRTSTS 180
  181 TSSSSSTRYI ASGSSNLAGG NSNSASSASS KTRFQSFLQQ PEGAHGFLTA HQKHVRQFVR 240
  241 STSAHSEAAA GVAGARAEKC IRSASTQIDD ASVAGVVESA GNLTDSSATG GSMQLSMSKL 300
  301 GLQQSSSILI SKSAETIEMK SSSAGMRTQL TLSGGFLAPP GNRKITILSP IHAPPGLHDM 360
  361 LKRAQGRSPL SPRISFPGSD SDLFGFDVEN GQGARSPLEG GSPSAGLVLQ NLPQRRESFL 420
  421 YRSDSDFEMS PKSMSRNSSI ASERFKEQEA SILVDRSHGE DLIVTPFAQI LASLRSVRNN 480
  481 LLSLTNVPAS NKRPNQSSSA SRSGNPPGAP LSQGEEAYTR LATDTIEELD WCLDQLETIQ 540
  541 THRSVSDMAS LKFKRMLNKE LSHFSESSRS GNQISEYICS TFLDKQQEFD LPSLRVEDNP 600
  601 ELVAANAAAG QQSAGQYARS RSPRGPPMSQ ISGVKRPLSH TNSFTGERLP TFGVETPREN 660
  661 ELGTLLGELD TWGIQIFSIG EFSVNRPLTC VAYTIFQSRE LLTSLMIPPK TFLNFMSTLE 720
  721 DHYVKDNPFH NSLHAADVTQ STNVLLNTPA LEGVFTPLEV GGALFAACIH DVDHPGLTNQ 780
  781 FLVNSSSELA LMYNDESVLE NHHLAVAFKL LQNQGCDIFC NMQKKQRQTL RKMVIDIVLS 840
  841 TDMSKHMSLL ADLKTMVETK KVAGSGVLLL DNYTDRIQVL ENLVHCADLS NPTKPLPLYK 900
  901 RWVALLMEEF FLQGDKERES GMDISPMCDR HNATIEKSQV GFIDYIVHPL WETWADLVHP 960
  961 DAQDILDTLE ENRDYYQSMI PPSPPPSGVD ENPQEDRIRF QVTLEESDQE NLAELEEGDE1020
 1021 SGGESTTTGT TGTTAASALS GAGGGGGGGG GMAPRTGGCQ NQPQHGGM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..173] deduced N/A No confident structure predictions are available.
    2 View Details [174..293] MSA 5.134997 View MSA. No confident structure predictions are available.
    3 View Details [294..572] deduced N/A No confident structure predictions are available.
    4 View Details [573..1068] PSI-BLAST 145.0 No description for 2fm0A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • cyclic-nucleotide phosphodiesterase activity
    		•  4.70762025272187 bayes_pls_golite062009
  • 3',5'-cyclic-nucleotide phosphodiesterase activity
    		•  4.66767157264894 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  4.40961779134517 bayes_pls_golite062009
  • 3',5'-cyclic-AMP phosphodiesterase activity
    		•  3.68838886134169 bayes_pls_golite062009
  • 3',5'-cyclic-GMP phosphodiesterase activity
    		•  2.64567538445993 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.26293733853576 bayes_pls_golite062009
  • hydrolase activity
    		•  1.17086565360856 bayes_pls_golite062009
  • catalytic activity
    		•  1.07048165010262 bayes_pls_golite062009
  • binding
    		•  0.994379083280533 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.893957699588543 bayes_pls_golite062009
  • protein binding
    		•  0.162314119157812 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle