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Protein Overview: SMG7

General Information:
Name(s) found: SMG7 [HGNC (HUGO)]
Description(s) found:
Found 26 descriptions.
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  • Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 1137 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY ALDKKVEQDL  60
   61 WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG FYTQLLQELC TVFNVDLPCR 120
  121 VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ 180
  181 LVPSNGQPYN QLAILASSKG DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV 240
  241 KTKWGVSDFI KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI 300
  301 NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE SQEESYNAYP 360
  361 LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF HPHEEDLSSI SATPLPEEFE 420
  421 LQGFLALRPS FRNLDFSKGH QGITGDKEGQ QRRIRQQRLI SIGKWIADNQ PRLIQCENEV 480
  481 GKLLFITEIP ELILEDPSEA KENLILQETS VIESLAADGS PGLKSVLSTS RNLSNNCDTG 540
  541 EKPVVTFKEN IKTREVNRDQ GRSFPPKEVR RDYSKGITVT KNDGKKDNNK RKTETKKCTL 600
  601 EKLQETGKQN VAVQVKSQTE LRKTPVSEAR KTPVTQTPTQ ASNSQFIPIH HPGAFPPLPS 660
  661 RPGFPPPTYV IPPPVAFSMG SGYTFPAGVS VPGTFLQPTA HSPAGNQVQA GKQSHIPYSQ 720
  721 QRPSGPGPMN QGPQQSQPPS QQPLTSLPAQ PTAQSTSQLQ VQALTQQQQS PTKAVPALGK 780
  781 SPPHHSGFQQ YQQADASKQL WNPPQVQGPL GKIMPVKQPY YLQTQDPIKL FEPSLQPPVM 840
  841 QQQPLEKKMK PFPMEPYNHN PSEVKVPEFY WDSSYSMADN RSVMAQQANI DRRGKRSPGV 900
  901 FRPEQDPVPR MPFEKSLLEK PSELMSHSSS FLSLTGFSLN QERYPNNSMF NEVYGKNLTS 960
  961 SSKAELSPSM APQETSLYSL FEGTPWSPSL PASSDHSTPA SQSPHSSNPS SLPSSPPTHN1020
 1021 HNSVPFSNFG PIGTPDNRDR RTADRWKTDK PAMGGFGIDY LSATSSSESS WHQASTPSGT1080
 1081 WTGHGPSMED SSAVLMESLK SIWSSSMMHP GPSALEQLLM QQKQKQQRGQ GTMNPPH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..497] PSI-BLAST 1000.0 Crystal structure of the N-terminal domain of human SMG7
    2 View Details [498..637] deduced N/A No confident structure predictions are available.
    3 View Details [638..869] MSA 2.281997 View MSA. No confident structure predictions are available.
    4 View Details [870..992] deduced N/A No confident structure predictions are available.
    5 View Details [993..1137] FFAS03 1.05 Chondroitinase B

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.71974493738804 bayes_pls_golite062009
  • phosphatase activity
    		•  2.07121787064839 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.0064822460534 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.93890458151007 bayes_pls_golite062009
  • protein binding
    		•  1.6279032205159 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  1.5101001424727 bayes_pls_golite062009
  • protein phosphatase 2A binding
    		•  1.46939554648762 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.4301086471216 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.22236203837379 bayes_pls_golite062009
  • DNA binding
    		•  1.20537879865251 bayes_pls_golite062009
  • RNA binding
    		•  1.1868411700113 bayes_pls_golite062009
  • signal sequence binding
    		•  0.71760275307167 bayes_pls_golite062009
  • transcription factor activity
    		•  0.565947156932776 bayes_pls_golite062009
  • hydrolase activity
    		•  0.252678932946087 bayes_pls_golite062009
  • transcription factor binding
    		•  0.165601865897969 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  0.138767551347851 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • catalytic activity
    		•  0.647299603114184 bayes_pls_golite062009
  • hydrolase activity
    		•  0.496523474039919 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle