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Protein Overview: gi|55957427, gi|...

General Information:
Name(s) found: gi|55957427 [NCBI NR]
gi|55663742 [NCBI NR]
gi|37620181 [NCBI NR]
gi|24659293 [NCBI NR]
gi|119574648 [NCBI NR]
gi|119574646 [NCBI NR]
Description(s) found:
Found 27 descriptions.
SHOW ALL
  • gi|55957427|emb|CAI16032.1| hect domain and RLD 4 [Homo sapiens] [NCBI NR]
  • gi|55663742|emb|CAH74148.1| hect domain and RLD 4 [Homo sapiens] [NCBI NR]
  • gi|37620181|ref|NP_056416.2| hect domain and RLD 4 isoform b [Homo sapiens] [NCBI NR]
  • gi|24659293|gb|AAH39600.1| Hect domain and RLD 4 [Homo sapiens] [NCBI NR]
  • gi|119574648|gb|EAW54263.1| hect domain and RLD 4, isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119574646|gb|EAW54261.1| hect domain and RLD 4, isoform CRA_b [Homo sapiens] [NCBI NR]
    • Organism: Homo sapiens
    Length: 1049 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FINKRVRDVG CGLRHTVFVL DDGTVYTCGC  60
   61 NDLGQLGHEK SRKKPEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLVG 120
  121 SEECIRVPRN IKSLSDIQIV QVACGYYHSL ALSKASEVFC WGQNKYGQLG LGTDCKKQTS 180
  181 PQLLKSLLGI PFMQVAAGGA HSFVLTLSGA IFGWGRNKFG QLGLNDENDR YVPNLLKSLR 240
  241 SQKIVYICCG EDHTAALTKE GGVFTFGAGG YGQLGHNSTS HEINPRKVFE LMGSIVTEIA 300
  301 CGRQHTSAFV PSSGRIYSFG LGGNGQLGTG STSNRKSPFT VKGNWYPYNG QCLPDIDSEE 360
  361 YFCVKRIFSG GDQSFSHYSS PQNCGPPDDF RCPNPTKQIW TVNEALIQKW LSYPSGRFPV 420
  421 EIANEIDGTF SSSGCLNGSF LAVSNDDHYR TGTRFSGVDM NAARLLFHKL IQPDHPQISQ 480
  481 QVAASLEKNL IPKLTSSLPD VEALRFYLTL PECPLMSDSN NFTTIAIPFG TALVNLEKAP 540
  541 LKVLENWWSV LEPPLFLKIV ELFKEVVVHL LKLYKIGIPP SERRIFNSFL HTALKVLEIL 600
  601 HRVNEKMGQI IQYDKFYIHE VQELIDIRND YINWVQQQAY GMLADIPVTI CTYPFVFDAQ 660
  661 AKTTLLQTDA VLQMQMAIDQ AHRQNVSSLF LPVIESVNPC LILVVRRENI VGDAMEVLRK 720
  721 TKNIDYKKPL KVIFVGEDAV DAGGVRKEFF LLIMRELLDP KYGMFRYYED SRLIWFSDKT 780
  781 FEDSDLFHLI GVICGLAIYN CTIVDLHFPL ALYKKLLKKK PSLDDLKELM PDVGRSMQQL 840
  841 LDYPEDDIEE TFCLNFTITV ENFGATEVKE LVLNGADTAV NKQNRQEFVD AYVDYIFNKS 900
  901 VASLFDAFHA GFHKVCGGKV LLLFQPNELQ AMVIGNTNYD WKELEKNTEY KGEYWAEHPT 960
  961 IKIFWEVFHE LPLEKKKQFL LFLTGSDRIP ILGMKSLKLV IQSTGGGEEY LPVSHTCFNL1020
 1021 LDLPKYTEKE TLRSKLIQAI DHNEGFSLI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..396] PSI-BLAST 79.69897 Regulator of chromosome condensation RCC1
    2 View Details [397..599] deduced N/A No confident structure predictions are available.
    3 View Details [600..673] PSI-BLAST 4.69897 NMR structure of WW domains (WW3-4) from Suppressor of Deltex
    4 View Details [674..1049] PSI-BLAST 125.0 Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  2.30582340315619 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  2.14217234009086 bayes_pls_golite062009
  • binding
    		•  1.94765972306941 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.48653812089482 bayes_pls_golite062009
  • histone binding
    		•  1.28399202516399 bayes_pls_golite062009
  • Ran guanyl-nucleotide exchange factor activity
    		•  1.24028661217618 bayes_pls_golite062009
  • protein binding
    		•  0.568399753749593 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.430728853345933 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.290397858094315 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.284277561587354 bayes_pls_golite062009
  • catalytic activity
    		•  0.261970921089142 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.185600765994903 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.169745277614311 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.0831999559001558 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.0619395994301855 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • proline-rich region binding
    		•  2.77294348104858 bayes_pls_golite062009
  • binding
    		•  2.62219069341981 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  2.59532734096591 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  2.41863405676058 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.33264761933582 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.90194027965368 bayes_pls_golite062009
  • transcription activator activity
    		•  1.87210371471023 bayes_pls_golite062009
  • transcription factor binding
    		•  1.83376274580017 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.72151886894232 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.6967322982151 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.57012978813321 bayes_pls_golite062009
  • protein binding
    		•  1.46903005775608 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  1.14806422628668 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  1.14806422628668 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  1.14806422628668 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  1.121001087082 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.568363753662296 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.2295693429366 bayes_pls_golite062009
  • catalytic activity
    		•  0.210712504691113 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K36 specific)
    		•  0.173723075520888 bayes_pls_golite062009
    4
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  7.14616396317218 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  6.99796579811325 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.03005793772151 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  4.50502148129705 bayes_pls_golite062009
  • sodium channel inhibitor activity
    		•  3.64966529121446 bayes_pls_golite062009
  • proline-rich region binding
    		•  3.26053533977534 bayes_pls_golite062009
  • binding
    		•  2.51893471705946 bayes_pls_golite062009
  • phosphothreonine binding
    		•  2.3451206920409 bayes_pls_golite062009
  • phosphoserine binding
    		•  2.3451206920409 bayes_pls_golite062009
  • ion channel inhibitor activity
    		•  2.14402963004533 bayes_pls_golite062009
  • channel inhibitor activity
    		•  2.14402963004533 bayes_pls_golite062009
  • ligase activity
    		•  2.05648169328967 bayes_pls_golite062009
  • protein binding
    		•  1.39373180706125 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.38689242583701 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.31506908210196 bayes_pls_golite062009
  • DNA binding
    		•  1.21570616111855 bayes_pls_golite062009
  • sodium channel regulator activity
    		•  1.19047973745862 bayes_pls_golite062009
  • catalytic activity
    		•  1.15152367676155 bayes_pls_golite062009
  • ubiquitin-ubiquitin ligase activity
    		•  0.598436219078807 bayes_pls_golite062009
  • transcription factor binding
    		•  0.450943150497874 bayes_pls_golite062009
  • channel regulator activity
    		•  0.072778668515899 bayes_pls_golite062009
    		• 0.051942165438844 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.42

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle