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View Structure Prediction Details

Protein: gi|55957427, gi|...
Organism: Homo sapiens
Length: 1049 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|55957427, gi|....

Description E-value Query
Range		 Subject
Range
gi|55250203 - gb|AAH86223.1| Unknown (protein for MGC:98711) [Xenopus laevis]
gi|74188723, gi|... - gi|74188723|dbj|BAE28095.1| unnamed protein product [Mus musculus], gi|32451488|ref|NP_080377.2| hec...
 0.0 [1..1049] [1..1049]
HERC4_RAT - Probable E3 ubiquitin-protein ligase HERC4 OS=Rattus norvegicus GN=Herc4 PE=2 SV=1
 0.0 [1..1049] [1..1057]
gi|114630756, gi... - gi|114630758|ref|XP_001167783.1| PREDICTED: hect domain and RLD 4 isoform 9 [Pan troglodytes], gi|11...
 0.0 [1..1049] [1..1049]
gi|109089621 - gi|109089621|ref|XP_001087737.1| PREDICTED: similar to hect domain and RLD 4 isoform b isoform 6 [Ma...
 0.0 [1..1049] [1..1049]
gi|73952755 - gi|73952755|ref|XP_536367.2| PREDICTED: similar to hect domain and RLD 4 isoform b isoform 1 [Canis ...
 0.0 [1..1049] [1..1049]
HERC4 - hect domain and RLD 4
 0.0 [1..1049] [1..1057]

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Predicted Domain #1
Region A:
Residues: [1-396] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FINKRVRDVG CGLRHTVFVL DDGTVYTCGC  60
   61 NDLGQLGHEK SRKKPEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLVG 120
  121 SEECIRVPRN IKSLSDIQIV QVACGYYHSL ALSKASEVFC WGQNKYGQLG LGTDCKKQTS 180
  181 PQLLKSLLGI PFMQVAAGGA HSFVLTLSGA IFGWGRNKFG QLGLNDENDR YVPNLLKSLR 240
  241 SQKIVYICCG EDHTAALTKE GGVFTFGAGG YGQLGHNSTS HEINPRKVFE LMGSIVTEIA 300
  301 CGRQHTSAFV PSSGRIYSFG LGGNGQLGTG STSNRKSPFT VKGNWYPYNG QCLPDIDSEE 360
  361 YFCVKRIFSG GDQSFSHYSS PQNCGPPDDF RCPNPT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 79.69897
Match: 1i2mB
Description: Regulator of chromosome condensation RCC1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 2.30582340315619 bayes_pls_golite062009
small conjugating protein ligase activity 2.14217234009086 bayes_pls_golite062009
binding 1.94765972306941 bayes_pls_golite062009
acid-amino acid ligase activity 1.48653812089482 bayes_pls_golite062009
histone binding 1.28399202516399 bayes_pls_golite062009
Ran guanyl-nucleotide exchange factor activity 1.24028661217618 bayes_pls_golite062009
protein binding 0.568399753749593 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.430728853345933 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.290397858094315 bayes_pls_golite062009
GTPase regulator activity 0.284277561587354 bayes_pls_golite062009
catalytic activity 0.261970921089142 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.185600765994903 bayes_pls_golite062009
enzyme regulator activity 0.169745277614311 bayes_pls_golite062009
small GTPase regulator activity 0.0831999559001558 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.0619395994301855 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [397-599] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQIWTVNEAL IQKWLSYPSG RFPVEIANEI DGTFSSSGCL NGSFLAVSND DHYRTGTRFS  60
   61 GVDMNAARLL FHKLIQPDHP QISQQVAASL EKNLIPKLTS SLPDVEALRF YLTLPECPLM 120
  121 SDSNNFTTIA IPFGTALVNL EKAPLKVLEN WWSVLEPPLF LKIVELFKEV VVHLLKLYKI 180
  181 GIPPSERRIF NSFLHTALKV LEI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [600-673] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LHRVNEKMGQ IIQYDKFYIH EVQELIDIRN DYINWVQQQA YGMLADIPVT ICTYPFVFDA  60
   61 QAKTTLLQTD AVLQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 1tk7A
Description: NMR structure of WW domains (WW3-4) from Suppressor of Deltex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
proline-rich region binding 2.77294348104858 bayes_pls_golite062009
binding 2.62219069341981 bayes_pls_golite062009
ubiquitin-protein ligase activity 2.59532734096591 bayes_pls_golite062009
small conjugating protein ligase activity 2.41863405676058 bayes_pls_golite062009
transcription regulator activity 2.33264761933582 bayes_pls_golite062009
histone methyltransferase activity 1.90194027965368 bayes_pls_golite062009
transcription activator activity 1.87210371471023 bayes_pls_golite062009
transcription factor binding 1.83376274580017 bayes_pls_golite062009
transcription cofactor activity 1.72151886894232 bayes_pls_golite062009
acid-amino acid ligase activity 1.6967322982151 bayes_pls_golite062009
transcription coactivator activity 1.57012978813321 bayes_pls_golite062009
protein binding 1.46903005775608 bayes_pls_golite062009
lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
protein methyltransferase activity 1.121001087082 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.568363753662296 bayes_pls_golite062009
transcription repressor activity 0.2295693429366 bayes_pls_golite062009
catalytic activity 0.210712504691113 bayes_pls_golite062009
histone methyltransferase activity (H3-K36 specific) 0.173723075520888 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [674-1049] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQMAIDQAHR QNVSSLFLPV IESVNPCLIL VVRRENIVGD AMEVLRKTKN IDYKKPLKVI  60
   61 FVGEDAVDAG GVRKEFFLLI MRELLDPKYG MFRYYEDSRL IWFSDKTFED SDLFHLIGVI 120
  121 CGLAIYNCTI VDLHFPLALY KKLLKKKPSL DDLKELMPDV GRSMQQLLDY PEDDIEETFC 180
  181 LNFTITVENF GATEVKELVL NGADTAVNKQ NRQEFVDAYV DYIFNKSVAS LFDAFHAGFH 240
  241 KVCGGKVLLL FQPNELQAMV IGNTNYDWKE LEKNTEYKGE YWAEHPTIKI FWEVFHELPL 300
  301 EKKKQFLLFL TGSDRIPILG MKSLKLVIQS TGGGEEYLPV SHTCFNLLDL PKYTEKETLR 360
  361 SKLIQAIDHN EGFSLI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 125.0
Match: 1c4zA
Description: Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 7.14616396317218 bayes_pls_golite062009
small conjugating protein ligase activity 6.99796579811325 bayes_pls_golite062009
acid-amino acid ligase activity 6.03005793772151 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 4.50502148129705 bayes_pls_golite062009
sodium channel inhibitor activity 3.64966529121446 bayes_pls_golite062009
proline-rich region binding 3.26053533977534 bayes_pls_golite062009
binding 2.51893471705946 bayes_pls_golite062009
phosphothreonine binding 2.3451206920409 bayes_pls_golite062009
phosphoserine binding 2.3451206920409 bayes_pls_golite062009
ion channel inhibitor activity 2.14402963004533 bayes_pls_golite062009
channel inhibitor activity 2.14402963004533 bayes_pls_golite062009
ligase activity 2.05648169328967 bayes_pls_golite062009
protein binding 1.39373180706125 bayes_pls_golite062009
transcription regulator activity 1.38689242583701 bayes_pls_golite062009
nucleic acid binding 1.31506908210196 bayes_pls_golite062009
DNA binding 1.21570616111855 bayes_pls_golite062009
sodium channel regulator activity 1.19047973745862 bayes_pls_golite062009
catalytic activity 1.15152367676155 bayes_pls_golite062009
ubiquitin-ubiquitin ligase activity 0.598436219078807 bayes_pls_golite062009
transcription factor binding 0.450943150497874 bayes_pls_golite062009
channel regulator activity 0.072778668515899 bayes_pls_golite062009
0.051942165438844 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle