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Protein Overview: CASP2

General Information:
Name(s) found: CASP2 [HGNC (HUGO)]
Description(s) found:
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  • gi|83300977|sp|P42575.2|CASP2_HUMAN RecName: Full=Caspase-2; Short=CASP-2; AltName: Full=ICH-1 protease; AltName: Full=Neural precursor cell expressed developmentally down-regulated protein 2; Short=NEDD-2; Contains: RecName: Full=Caspase-2 subunit p18; C [NCBI NR]
  • gi|39995059|ref|NP_116764.2| caspase 2 isoform 1 preproprotein [Homo sapiens] [NCBI NR]
  • gi|158255984|dbj|BAF83963.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|119572255|gb|EAW51870.1| hCG20684, isoform CRA_c [Homo sapiens] [NCBI NR]
  • gi|119572252|gb|EAW51867.1| hCG20684, isoform CRA_c [Homo sapiens] [NCBI NR]
  • gi|119572248|gb|EAW51863.1| hCG20684, isoform CRA_c [Homo sapiens] [NCBI NR]
  • caspase 2, apoptosis-related cysteine peptidase [HGNC (HUGO)]
  • Caspase-2 OS=Homo sapiens GN=CASP2 PE=1 SV=2 [Swiss-Prot]
  • caspase 2 isoform 1 preproprotein; ICH-1 protease; NEDD2 apoptosis regulatory gene [HMR_022704.fasta]
  • caspase 2 isoform 1 preproprotein [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 Splice Isoform ICH-1L of Caspase-2 precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • caspase 2 isoform 1 preproprotein; ICH-1 protease; NEDD2 apoptosis regulatory gene [Homo sapiens] [HumanGallus06162005.fasta]
  • Caspase-2 precursor (CASP-2) (ICH-1 protease) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD2 protein) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • hCG20684, isoform CRA_c [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform ICH-1L of Caspase-2 precursor [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=CASP2 Isoform ICH-1L of Caspase-2 [human-ipi-250309-contam.fasta]
  • Caspase-2 precursor (CASP-2) (ICH-1 protease) (ICH-1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] [nr-271106-contam.fasta]
  • IPI:IPI00291570.9|SWISS-PROT:P42575-1|TREMBL:A8K5F9;B4E085;B4E0I5|ENSEMBL:ENSP00000312664|REFSEQ:NP_116764|H-INV:HIT000270625|VEGA:OTTHUMP00000025259 Tax_Id=9606 Gene_Symbol=CASP2 Isoform ICH-1L of Caspase-2 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=CASP2 Isoform ICH-1L of Caspase-2 precursor ENSG00000106144 IPI00291570 IPI00216410 IPI00018345 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=CASP2 Isoform ICH-1L of Caspase-2 precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=CASP2 Isoform 1 of Caspase-2 [EBI-IPI_Human_3.71_03-24-2010_reversed.fasta]
  • caspase-2 isoform 1 preproprotein [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P42575;A8K5F9;P42576;Q59F21;Q7KZL6;Q86UJ3;Q9BUP7;Q9BZK9; RecName: Full=Caspase-2; AltName: Full=Protease ICH-1; AltName: Full=Neural precursor cell expressed developmentally down-regulated protein 2; Contains: RecName: Full=Caspase-2 subunit p18; Contains: RecName: Full=Caspase-2 subunit p13; Contains: RecName: Full=Caspase-2 subunit p12; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Caspase-2 OS=Homo sapiens GN=CASP2 [011711_HMR.fasta]
  • IPI:IPI00291570.9|SWISS-PROT:P42575-1|TREMBL:B4E085;B4E0I5;D3DXD6;D3DXE0|ENSEMBL:ENSP00000312664|REFSEQ:NP_116764|H-INV:HIT000270625|VEGA:OTTHUMP00000025259 Tax_Id=9606 Gene_Symbol=CASP2 Isoform 1 of Caspase-2 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=CASP2 Synonyms=CASP-2|ICH1|NEDD-2|NEDD2 caspase-2 isoform 1 preproprotein [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00291570.9|SWISS-PROT:P42575-1|TREMBL:B4E085;B4E0I5;D3DXE0|ENSEMBL:ENSP00000312664|REFSEQ:NP_116764|H-INV:HIT000270625|VEGA:OTTHUMP00000025259 Tax_Id=9606 Gene_Symbol=CASP2 Isoform 1 of Caspase-2 [ipi.HUMAN.20110912.fasta]
  • Caspase-2 GN=CASP2 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 452 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAPSAGSWS TFQHKELMAA DRGRRILGVC GMHPHHQETL KKNRVVLAKQ LLLSELLEHL  60
   61 LEKDIITLEM RELIQAKVGS FSQNVELLNL LPKRGPQAFD AFCEALRETK QGHLEDMLLT 120
  121 TLSGLQHVLP PLSCDYDLSL PFPVCESCPL YKKLRLSTDT VEHSLDNKDG PVCLQVKPCT 180
  181 PEFYQTHFQL AYRLQSRPRG LALVLSNVHF TGEKELEFRS GGDVDHSTLV TLFKLLGYDV 240
  241 HVLCDQTAQE MQEKLQNFAQ LPAHRVTDSC IVALLSHGVE GAIYGVDGKL LQLQEVFQLF 300
  301 DNANCPSLQN KPKMFFIQAC RGDETDRGVD QQDGKNHAGS PGCEESDAGK EKLPKMRLPT 360
  361 RSDMICGYAC LKGTAAMRNT KRGSWYIEAL AQVFSERACD MHVADMLVKV NALIKDREGY 420
  421 APGTEFHRCK EMSEYCSTLC RHLYLFPGHP PT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..177] PSI-BLAST 18.39794 Structure of the apoptotic protease-activating factor 1 bound to ADP
    2 View Details [178..331] PSI-BLAST 47.30103 Crystal Structure of Human Caspase-2 in Complex with Acetyl-Leu-Asp-Glu-Ser-Asp-cho
    3 View Details [332..452] PSI-BLAST 27.522879 Crystal Structure of Human Caspase-2 in Complex with Acetyl-Leu-Asp-Glu-Ser-Asp-cho

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.24815349282067 bayes_pls_golite062009
  • protein binding
    		•  2.96725373477762 bayes_pls_golite062009
  • binding
    		•  2.91261616137775 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  2.60103365510479 bayes_pls_golite062009
  • hydrolase activity
    		•  2.45602706385958 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  2.37850336421322 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.07426831021634 bayes_pls_golite062009
  • apoptotic protease activator activity
    		•  2.001549901512 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.82979469421101 bayes_pls_golite062009
  • endopeptidase activity
    		•  1.58137850574981 bayes_pls_golite062009
  • cyclin-dependent protein kinase inhibitor activity
    		•  1.38256499817012 bayes_pls_golite062009
  • catalytic activity
    		•  1.03907950272772 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.0737251792690711 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle