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Protein Overview: TPP2

General Information:
Name(s) found: TPP2 [HGNC (HUGO)]
Description(s) found:
Found 22 descriptions.
SHOW ALL
  • tripeptidyl peptidase II [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 1249 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATAATEEPF PFHGLLPKKE TGAASFLCRY PEYDGRGVLI AVLDTGVDPG APGMQVTTDG  60
   61 KPKIVDIIDT TGSGDVNTAT EVEPKDGEIV GLSGRVLKIP ASWTNPSGKY HIGIKNGYDF 120
  121 YPKALKERIQ KERKEKIWDP VHRVALAEAC RKQEEFDVAN NGSSQANKLI KEELQSQVEL 180
  181 LNSFEKKYSD PGPVYDCLVW HDGEVWRACI DSNEDGDLSK STVLRNYKEA QEYGSFGTAE 240
  241 MLNYSVNIYD DGNLLSIVTS GGAHGTHVAS IAAGHFPEEP ERNGVAPGAQ ILSIKIGDTR 300
  301 LSTMETGTGL IRAMIEVINH KCDLVNYSYG EATHWPNSGR ICEVINEAVW KHNIIYVSSA 360
  361 GNNGPCLSTV GCPGGTTSSV IGVGAYVSPD MMVAEYSLRE KLPANQYTWS SRGPSADGAL 420
  421 GVSISAPGGA IASVPNWTLR GTQLMNGTSM SSPNACGGIA LILSGLKANN IDYTVHSVRR 480
  481 ALENTAVKAD NIEVFAQGHG IIQVDKAYDY LVQNTSFANK LGFTVTVGNN RGIYLRDPVQ 540
  541 VAAPSDHGVG IEPVFPENTE NSEKISLQLH LALTSNSSWV QCPSHLELMN QCRHINIRVD 600
  601 PRGLREGLHY TEVCGYDIAS PNAGPLFRVP ITAVIAAKVN ESSHYDLAFT DVHFKPGQIR 660
  661 RHFIEVPEGA TWAEVTVCSC SSEVSAKFVL HAVQLVKQRA YRSHEFYKFC SLPEKGTLTE 720
  721 AFPVLGGKAI EFCIARWWAS LSDVNIDYTI SFHGIVCTAP QLNIHASEGI NRFDVQSSLK 780
  781 YEDLAPCITL KNWVQTLRPV SAKTKPLGSR DVLPNNRQLY EMVLTYNFHQ PKSGEVTPSC 840
  841 PLLCELLYES EFDSQLWIIF DQNKRQMGSG DAYPHQYSLK LEKGDYTIRL QIRHEQISDL 900
  901 ERLKDLPFIV SHRLSNTLSL DIHENHSFAL LGKKKSSNLT LPPKYNQPFF VTSLPDDKIP 960
  961 KGAGPGCYLA GSLTLSKTEL GKKADVIPVH YYLIPPPTKT KNGSKDKEKD SEKEKDLKEE1020
 1021 FTEALRDLKI QWMTKLDSSD IYNELKETYP NYLPLYVARL HQLDAEKERM KRLNEIVDAA1080
 1081 NAVISHIDQT ALAVYIAMKT DPRPDAATIK NDMDKQKSTL VDALCRKGCA LADHLLHTQA1140
 1141 QDGAISTDAE GKEEEGESPL DSLAETFWET TKWTDLFDNK VLTFAYKHAL VNKMYGRGLK1200
 1201 FATKLVEEKP TKENWKNCIQ LMKLLGWTHC ASFTENWLPI MYPPDYCVF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..518] PSI-BLAST 6.69897 Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin
    2 View Details [519..644] PSI-BLAST 61.69897 Furin, C-terminal domain; Furin, N-terminal domain
    3 View Details [645..729] deduced N/A No confident structure predictions are available.
    4 View Details [730..1249] FFAS03 2.2 No description for 2gw1A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  3.80926331563638 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.44676270522493 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.34981838083066 bayes_pls_golite062009
  • hydrolase activity
    		•  1.91868221854892 bayes_pls_golite062009
  • serine hydrolase activity
    		•  1.90036575189745 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  1.89198766955068 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  1.23150012549143 bayes_pls_golite062009
  • catalytic activity
    		•  0.597535457699629 bayes_pls_golite062009
  • binding
    		•  0.38308887521311 bayes_pls_golite062009
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.80926331563638 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.44676270522493 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.34981838083066 bayes_pls_golite062009
  • hydrolase activity
    		•  1.91868221854892 bayes_pls_golite062009
  • serine hydrolase activity
    		•  1.90036575189745 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  1.89198766955068 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  1.23150012549143 bayes_pls_golite062009
  • catalytic activity
    		•  0.597535457699629 bayes_pls_golite062009
  • binding
    		•  0.38308887521311 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle