Protein Overview: PRKN2_RAT

General Information:
Name(s) found:	PRKN2_RAT [Swiss-Prot]
Description(s) found: Found 15 descriptions. SHOW ALL	E3 ubiquitin-protein ligase parkin OS=Rattus norvegicus GN=Park2 PE=1 SV=1 [Swiss-Prot]
Organism:	Rattus norvegicus
Length:	465 amino acids
Gene Ontology:
Cellular Component:	postsynaptic density [IDA] synaptic vesicle [IDA] Golgi membrane [IDA] endoplasmic reticulum [IDA] Golgi apparatus [UNKNOWN] protein complex [UNKNOWN] synapse [IEA] cell projection [IEA] neuron projection [UNKNOWN] intracellular [IDA] plasma membrane [IEA] nucleus [IEA] dendrite [IEA] perinuclear region of cytoplasm [UNKNOWN] cytoplasm [UNKNOWN][IEA] postsynaptic membrane [IEA] membrane raft [IDA] cytosol [UNKNOWN] cell junction [IEA] cytoplasmic vesicle [IDA] aggresome [UNKNOWN]
Biological Process:	norepinephrine metabolic process [UNKNOWN] protein metabolic process [UNKNOWN] [NOT]dopamine metabolic process [UNKNOWN] protein modification process [TAS] positive regulation of I-kappaB kinase/NF-kappaB cascade [UNKNOWN] neuron maturation [IEP] negative regulation of cell death [UNKNOWN] adult locomotory behavior [UNKNOWN] [NOT]learning [UNKNOWN] response to unfolded protein [IDA] synaptic transmission, dopaminergic [UNKNOWN] [NOT]locomotory behavior [UNKNOWN] startle response [UNKNOWN] dopamine uptake [UNKNOWN] aggresome assembly [UNKNOWN] protein autoubiquitination [UNKNOWN] regulation of neurotransmitter secretion [UNKNOWN] protein polyubiquitination [UNKNOWN] protein ubiquitination during ubiquitin-dependent protein catabolic process [UNKNOWN] ubiquitin-dependent protein catabolic process [TAS] response to corticosterone stimulus [IEP] negative regulation of protein amino acid phosphorylation [UNKNOWN] response to drug [IEP] regulation of synaptic transmission [UNKNOWN] protein K63-linked ubiquitination [UNKNOWN] negative regulation of actin filament bundle assembly [UNKNOWN] synaptic transmission, glutamatergic [UNKNOWN]
Molecular Function:	ubiquitin-protein ligase activity [UNKNOWN][TAS] zinc ion binding [IEA] protein binding [UNKNOWN] metal ion binding [IEA] chaperone binding [UNKNOWN] PDZ domain binding [UNKNOWN] acid-amino acid ligase activity [IEA] protein complex binding [IDA] ligase activity [IEA] kinase binding [UNKNOWN]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIVFVRFNSS YGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL QNHLTVQNCD  60
   61 LEQQSIVHIV QRPQRKSHET NASGGDKPQS TPEGSIWEPR SLTRVDLSSH ILPADSVGLA 120
  121 VILDTDSKSD SEAARGPEAK PTYHSFFVYC KGPCHKVQPG KLRVQCGTCR QATLTLAQGP 180
  181 SCWDDVLIPN RMSGECQSPD CPGTRAEFFF KCGAHPTSDK DTSVALNLIT NNSRSIPCIA 240
  241 CTDVRNPVLV FQCNHRHVIC LDCFHLYCVT RLNDRQFVHD AQLGYSLPCV AGCPNSLIKE 300
  301 LHHFRILGEE QYNRYQQYGA EECVLQMGGV LCPRPGCGAG LLPEQGQKKV TCEGGNGLGC 360
  361 GFVFCRDCKE AYHEGECDSM FEASGATSQA YRVDQRAAEQ ARWEEASKET IKKTTKPCPR 420
  421 CNVPIEKNGG CMHMKCPQPQ CKLEWCWNCG CEWNRACMGD HWFDV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: PRKN2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: