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Protein Overview: PO4F1_RAT

General Information:
Name(s) found: PO4F1_RAT [Swiss-Prot]
Description(s) found:
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  • gi|46397775|sp|P20266.2|PO4F1_RAT RecName: Full=POU domain, class 4, transcription factor 1; AltName: Full=Brain-specific homeobox/POU domain protein 3A; Short=Brn-3A [NCBI NR]
  • POU domain, class 4, transcription factor 1 (Fragment) OS=Rattus norvegicus GN=Pou4f1 PE=2 SV=2 [Swiss-Prot]
  • (P20266) POU domain, class 4, transcription factor 1 (Brain-specific homeobox/POU domain protein 3A) (Brn-3A) (Fragment) [Swiss-Prot]
  • POU domain, class 4, transcription factor 1 (Brain-specific homeobox/POU domain protein 3A) (Brn-3A) [nrdb_11152004_Chlamydomonas]
  • POU domain, class 4, transcription factor 1 (Fragment) OS=Rattus norvegicus GN=Pou4f1 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 128 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IEA]
    Biological Process: multicellular organismal development [IEA]
    neuron differentiation [UNKNOWN]
    nervous system development [UNKNOWN][IEA]
    mesoderm development [UNKNOWN]
    regulation of transcription, DNA-dependent [UNKNOWN][IEA]
    transcription from RNA polymerase II promoter [TAS]
    cell migration in hindbrain [UNKNOWN][IEA]
    central nervous system neuron differentiation [UNKNOWN][IEA]
    peripheral nervous system neuron differentiation [UNKNOWN][IEA]
    proprioception during equilibrioception [UNKNOWN][IEA]
    negative regulation of apoptosis [TAS]
    suckling behavior [UNKNOWN][IEA]
    positive regulation of apoptosis [UNKNOWN][IEA]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN]
    regulation of neurogenesis [UNKNOWN]
    negative regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN]
    Molecular Function: DNA binding [UNKNOWN][TAS]
    transcription factor activity [UNKNOWN][IEA][TAS]
    protein binding [UNKNOWN][IEA]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRIKLGVTQA DVGSALANLK IPGVGSLSQS TICRFESLTL SHNNMIALKP ILQAWLEEAE  60
   61 GAQREKMNKP ELFNGGEKKR KRTSIAAPEK RSLEAYFAVQ PRPSSEKIAA IAEKLDLKKN 120
  121 VVRVWFCN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..128] PSI-BLAST 27.522879 Oct-1 POU Homeodomain; Oct-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA binding
    		•  5.51228466689923 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.37468811865033 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.05236457497789 bayes_pls_golite062009
  • transcription factor activity
    		•  3.89464979825638 bayes_pls_golite062009
  • binding
    		•  3.66501723413351 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.25218945600666 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22754992035091 bayes_pls_golite062009
  • transcription activator activity
    		•  3.15886611325686 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.75958281319075 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.62096064323298 bayes_pls_golite062009
  • protein binding
    		•  1.55649304400241 bayes_pls_golite062009
  • chromatin binding
    		•  1.2739759748489 bayes_pls_golite062009
  • transcription factor binding
    		•  1.02788976342343 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.92393807212912 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.8718993114781 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.81316180547536 bayes_pls_golite062009
  • promoter binding
    		•  0.22765608166458 bayes_pls_golite062009
  • catalytic activity
    		•  0.00446472034106909 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle