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Protein Overview: PAX6_RAT

General Information:
Name(s) found: PAX6_RAT [Swiss-Prot]
Description(s) found:
Found 17 descriptions.
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  • Paired box protein Pax-6 OS=Rattus norvegicus GN=Pax6 PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 422 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][UNKNOWN][IDA][IEA]
    cytoplasm [UNKNOWN]
    intracellular part [UNKNOWN]
    intracellular [UNKNOWN]
    Biological Process: regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment [UNKNOWN]
    multicellular organismal development [IEA]
    regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification [UNKNOWN]
    negative regulation of cell proliferation [UNKNOWN]
    regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification [UNKNOWN]
    response to wounding [UNKNOWN]
    anterior/posterior pattern formation [UNKNOWN]
    forebrain anterior/posterior pattern formation [UNKNOWN]
    negative regulation of neuron differentiation [UNKNOWN]
    transcription from RNA polymerase II promoter [IMP]
    axon guidance [UNKNOWN]
    forebrain dorsal/ventral pattern formation [UNKNOWN]
    dorsal/ventral axis specification [UNKNOWN]
    oligodendrocyte cell fate specification [UNKNOWN]
    regulation of neuron differentiation [IDA]
    lens development in camera-type eye [UNKNOWN]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    salivary gland morphogenesis [UNKNOWN]
    dorsal/ventral pattern formation [UNKNOWN]
    neuron migration [UNKNOWN][IMP]
    forebrain development [UNKNOWN]
    hindbrain development [IDA]
    lacrimal gland development [UNKNOWN]
    axonogenesis [UNKNOWN]
    camera-type eye development [UNKNOWN]
    regulation of epithelial cell proliferation [IMP]
    cell fate determination [UNKNOWN]
    forebrain-midbrain boundary formation [UNKNOWN]
    astrocyte differentiation [UNKNOWN]
    commitment of a neuronal cell to a specific type of neuron in the forebrain [UNKNOWN]
    eye photoreceptor cell development [UNKNOWN]
    positive regulation of cell fate specification [IMP]
    positive regulation of neuroblast proliferation [UNKNOWN]
    regulation of transcription, DNA-dependent [IEA]
    smoothened signaling pathway [UNKNOWN]
    brain development [UNKNOWN][IMP]
    pallium development [UNKNOWN]
    pituitary gland development [UNKNOWN]
    regulation of timing of cell differentiation [UNKNOWN]
    keratinocyte differentiation [UNKNOWN]
    positive regulation of epithelial cell differentiation [UNKNOWN]
    cell fate commitment [UNKNOWN]
    negative regulation of epithelial cell proliferation [UNKNOWN]
    regulation of gene expression [UNKNOWN]
    cell differentiation [UNKNOWN][IEA]
    protein localization in organelle [UNKNOWN]
    regulation of cell migration [UNKNOWN]
    regulation of neurogenesis [UNKNOWN][IMP]
    Molecular Function: DNA binding [UNKNOWN]
    transcription factor activity [UNKNOWN][IEA][TAS]
    protein binding [UNKNOWN]
    RNA polymerase II transcription factor activity [IMP]
    double-stranded DNA binding [IDA]
    AT DNA binding [IDA]
    sequence-specific DNA binding [IDA][IEA][RCA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQVSN GCVSKILGRY  60
   61 YETGSIRPRA IGGSKPRVAT PEVVSKIAQY KRECPSIFAW EIRDRLLSEG VCTNDNIPSV 120
  121 SSINRVLRNL ASEKQQMGAD GMYDKLRMLN GQTGSWGTRP GWYPGTSVPG QPTQDGCQQQ 180
  181 EGQGENTNSI SSNGEDSDEA QMRLQLKRKL QRNRTSFTQE QIEALEKEFE RTHYPDVFAR 240
  241 ERLAAKIDLP EARIQVWFSN RRAKWRREEK LRNQRRQASN TPSHIPISSS FSTSVYQPIP 300
  301 QPTTPVSSFT SGSMLGRTDT ALTNTYSALP PMPSFTMANN LPMQPPVPSQ TSSYSCMLPT 360
  361 SPSVNGRSYD TYTPPHMQTH MNSQPMGTSG TTSTGLISPG VSVPVQVPGS EPDMSQYWPR 420
  421 LQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle