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Protein Overview: mthl12-PA

General Information:
Name(s) found: mthl12-PA / FBpp0082214 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene methuselah-like 12 is referred to in FlyBase by the symbol Dmel\mthl12 (CG32853, FBgn0045442). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:9179395..9181135. It has the cytological map location 87E7. Based on sequence similarity, it is predicted to have molecular function</span>: G-protein coupled receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: G-protein coupled receptor protein signaling pathway; determination of adult lifespan; response to stress. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 488 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    integral to membrane [NAS]
    Biological Process: G-protein coupled receptor protein signaling pathway [ISS]
    determination of adult lifespan [ISS]
    cell surface receptor linked signaling pathway [IEA]
    response to stress [ISS]
    Molecular Function: G-protein coupled receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFLWLKCFCT LIIVTIAKNS SAKIPHCKYD ETINISHFKR LNDAYIYEHF EIPANLTGEF  60
   61 DYKELMDGSK VPTEFPNLRG CICKVRPCIR ICCARKNILS NGECSDGVKN EIKLTMLDLT 120
  121 MQDILLTDPT LAELNMIPQY NSTELLILRE QFQPCDEIVS LKRDEYTILK DGSILLHTSA 180
  181 EILSNDQYCL YPEIYSDFPE TIRIINRRCY RNVMPGIAQL SVISVVGFIL TLAVYLSVEK 240
  241 LRNLLGKCLI CSLFSMFMEY FIWTMDYFRL LQSICSAAGY MKYFFSMSSY LWFSVVSFHL 300
  301 WELFTSLNRH EPQYRFLIYN TFVWCTAAIP TVVIFSMNQM WENDPGKSEW LPLVGYFGCS 360
  361 VKDWNSSSWF YSHIPIVILN SFNVIMFVLT AIYIWKVKKG VKSFAQHDER NTTCLEFNVQ 420
  421 TYIQFVRLFL IMGASWLLDQ LTRLAEDSHL LLDTIVLNLT VYLNAAFGIL IFVLLILKGS 480
  481 TFKMIMER

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..193] PSI-BLAST 42.0 Methuselah ectodomain
    2 View Details [194..488] PSI-BLAST 46.522879 Rhodopsin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • G-protein coupled receptor activity
    		•  7.48253527316663 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  5.76968261800439 bayes_pls_golite062009
  • receptor activity
    		•  5.47976284348283 bayes_pls_golite062009
  • signal transducer activity
    		•  4.51388461085202 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.51388461085202 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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