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Protein Overview: grk-PA

General Information:
Name(s) found: grk-PA / FBpp0079313 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene gurken is referred to in FlyBase by the symbol Dmel\grk (CG17610, FBgn0001137). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:8431086..8433598. It has the cytological map location 29C4. It is reported to have molecular function</span>: gurken receptor binding; epidermal growth factor receptor binding. There is experimental evidence that it is involved in the biological process</span>: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded; establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification; oocyte microtubule cytoskeleton organization; border follicle cell migration; chorion-containing eggshell pattern formation. 80 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: organ system; egg; female germline cyst; adult segment; chorion; adult mesothoracic segment; thoracic segment; follicle cell; ventral furrow; cell part. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 295 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [TAS]
    extracellular region [NAS]
    Biological Process: chorion-containing eggshell pattern formation [IMP]
    epidermal growth factor receptor signaling pathway [NAS]
    anterior/posterior pattern formation [TAS]
    dorsal appendage formation [NAS]
    dorsal/ventral axis specification, ovarian follicular epithelium [NAS][TAS]
    border follicle cell migration [IMP][TAS]
    oocyte dorsal/ventral axis specification [NAS][TAS]
    embryonic axis specification [TAS]
    oocyte anterior/posterior axis specification [NAS][TAS]
    gurken receptor signaling pathway [NAS][TAS]
    oocyte axis specification [NAS][TAS]
    establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification [IMP]
    anterior/posterior axis specification, follicular epithelium [NAS][TAS]
    maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded [IMP]
    cell fate specification [TAS]
    cell fate determination [TAS]
    oocyte microtubule cytoskeleton organization [IMP]
    Molecular Function: epidermal growth factor receptor binding [NAS][TAS]
    gurken receptor binding [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMQIPFTRIF KVIFVLSTIV AVTDCCSSRI LLLREHTLKI VQHQHSHMHE HAHELQQQIQ  60
   61 ETAVELLNRL ELQRKQLEAS AQEEADQLHP DTDPNPDSGG QLPNADDSIA ADPEQDGIIL 120
  121 GSSTDTWLAS ESSTPITDSE TVTTPETVTH TGEPPPDPSS SSTPDSTTPS PNDKETEIQM 180
  181 LPCSEAYNTS FCLNGGHCFQ HPMVNNTVFH SCLCVNDYDG ERCAYKSWNG DYIYSPPTAQ 240
  241 RKVRMAHIVF SFPVLLMLSS LYVLFAAVFM LRNVPDYRRK QQQLHLHKQR FFVRC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..295] PSI-BLAST 4.522879 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • receptor binding
    		•  4.60755835611133 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  4.4860322783685 bayes_pls_golite062009
  • growth factor activity
    		•  4.38305031783896 bayes_pls_golite062009
  • binding
    		•  2.54996368217395 bayes_pls_golite062009
  • heparin binding
    		•  2.49012176521764 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.44185509650703 bayes_pls_golite062009
  • polysaccharide binding
    		•  2.16901652361989 bayes_pls_golite062009
  • protein binding
    		•  1.97546801934296 bayes_pls_golite062009
  • pattern binding
    		•  1.92168039086846 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.42853255302174 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.17748426017837 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.724489340907325 bayes_pls_golite062009
  • transcription factor binding
    		•  0.62178723762474 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.50737750327034 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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