YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: GIT1

General Information:
Name(s) found: GIT1 [HGNC (HUGO)]
Description(s) found:
SHOW ONLY BEST
  • gi|45645212|sp|Q9Y2X7.2|GIT1_HUMAN RecName: Full=ARF GTPase-activating protein GIT1; AltName: Full=G protein-coupled receptor kinase-interactor 1; AltName: Full=GRK-interacting protein 1; AltName: Full=Cool-associated and tyrosine-phosphorylated protein 1 [NCBI NR]
  • gi|41393573|ref|NP_054749.2| G protein-coupled receptor kinase interactor 1 isoform 2 [Homo sapiens] [NCBI NR]
  • gi|119571581|gb|EAW51196.1| G protein-coupled receptor kinase interactor 1, isoform CRA_a [Homo sapiens] [NCBI NR]
  • G protein-coupled receptor kinase interacting ArfGAP 1 [HGNC (HUGO)]
  • ARF GTPase-activating protein GIT1 OS=Homo sapiens GN=GIT1 PE=1 SV=2 [Swiss-Prot]
  • G protein-coupled receptor kinase-interactor 1; GIT1 protein [HMR_022704.fasta]
  • G protein-coupled receptor kinase interactor 1; GIT1 protein; G protein-coupled receptor kinase-interactor 1 [071204_hmrz_cont.fasta]
  • G protein-coupled receptor kinase interactor 1 [Homo sapiens]gi|45645212|sp|Q9Y2X7|GIT1_HUMAN ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated pro [nrdb_11152004_Chlamydomonas]
  • ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of ARF GTPase-activating protein GIT1 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • G protein-coupled receptor kinase interactor 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • G protein-coupled receptor kinase interactor 1; GIT1 protein; G protein-coupled receptor kinase-interactor 1 [Homo sapiens] [HumanGallus06162005.fasta]
  • G protein-coupled receptor kinase-interactor 1; GIT1 protein [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • G protein-coupled receptor kinase interactor 1 isoform 2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • G protein-coupled receptor kinase interactor 1, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of ARF GTPase-activating protein GIT1 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF ARF GTPASE-ACTIVATING PROTEIN GIT1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=GIT1 Isoform 1 of ARF GTPase-activating protein GIT1 [human-ipi-250309-contam.fasta]
  • IPI:IPI00384861.3|SWISS-PROT:Q9Y2X7-1|ENSEMBL:ENSP00000225394|REFSEQ:NP_054749|VEGA:OTTHUMP00000163605 Tax_Id=9606 Gene_Symbol=GIT1 Isoform 1 of ARF GTPase-activating protein GIT1 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • ARF GTPase-activating protein GIT1 isoform 2 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q9Y2X7;Q86SS0;Q9BRJ4; RecName: Full=ARF GTPase-activating protein GIT1; AltName: Full=G protein-coupled receptor kinase-interactor 1; AltName: Full=GRK-interacting protein 1; AltName: Full=Cool-associated and tyrosine-phosphorylated protein 1; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of ARF GTPase-activating protein GIT1 OS=Homo sapiens GN=GIT1 [011711_HMR.fasta]
  • GeneSymbol=GIT1 Synonyms=- ARF GTPase-activating protein GIT1 isoform 2 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00384861.3|SWISS-PROT:Q9Y2X7-1|TREMBL:B4DS81;Q6PIN6|ENSEMBL:ENSP00000225394|REFSEQ:NP_054749|VEGA:OTTHUMP00000163605 Tax_Id=9606 Gene_Symbol=GIT1 Isoform 1 of ARF GTPase-activating protein GIT1 [ipi.HUMAN.20110912.fasta]
  • ARF GTPase-activating protein GIT1 GN=GIT1 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 761 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRKGPRAEV CADCSAPDPG WASISRGVLV CDECCSVHRS LGRHISIVKH LRHSAWPPTL  60
   61 LQMVHTLASN GANSIWEHSL LDPAQVQSGR RKANPQDKVH PIKSEFIRAK YQMLAFVHKL 120
  121 PCRDDDGVTA KDLSKQLHSS VRTGNLETCL RLLSLGAQAN FFHPEKGTTP LHVAAKAGQT 180
  181 LQAELLVVYG ADPGSPDVNG RTPIDYARQA GHHELAERLV ECQYELTDRL AFYLCGRKPD 240
  241 HKNGHYIIPQ MADSLDLSEL AKAAKKKLQA LSNRLFEELA MDVYDEVDRR ENDAVWLATQ 300
  301 NHSTLVTERS AVPFLPVNPE YSATRNQGRQ KLARFNAREF ATLIIDILSE AKRRQQGKSL 360
  361 SSPTDNLELS LRSQSDLDDQ HDYDSVASDE DTDQEPLRST GATRSNRARS MDSSDLSDGA 420
  421 VTLQEYLELK KALATSEAKV QQLMKVNSSL SDELRRLQRE IHKLQAENLQ LRQPPGPVPT 480
  481 PPLPSERAEH TPMAPGGSTH RRDRQAFSMY EPGSALKPFG GPPGDELTTR LQPFHSTELE 540
  541 DDAIYSVHVP AGLYRIRKGV SASAVPFTPS SPLLSCSQEG SRHTSKLSRH GSGADSDYEN 600
  601 TQSGDPLLGL EGKRFLELGK EEDFHPELES LDGDLDPGLP STEDVILKTE QVTKNIQELL 660
  661 RAAQEFKHDS FVPCSEKIHL AVTEMASLFP KRPALEPVRS SLRLLNASAY RLQSECRKTV 720
  721 PPEPGAPVDF QLLTQQVIQC AYDIAKAAKQ LVTITTREKK Q

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..472] PSI-BLAST 50.522879 Ankyrin-R
    2 View Details [473..639] MSA 1.454996 View MSA. No confident structure predictions are available.
    3 View Details [640..761] FFAS03 1.07 FAT domain of focal adhesion kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.60916417202222 bayes_pls_golite062009
  • protein binding
    		•  1.64872738860757 bayes_pls_golite062009
  • signal transducer activity
    		•  1.2375987667709 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.2375987667709 bayes_pls_golite062009
  • receptor activity
    		•  1.22857731988464 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.10325771560525 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.708360875374323 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.589753112911856 bayes_pls_golite062009
  • peptide binding
    		•  0.215454111067296 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.156667528524505 bayes_pls_golite062009
  • DNA binding
    		•  0.139886855398905 bayes_pls_golite062009
  • transcription factor binding
    		•  0.11440400380364 bayes_pls_golite062009
  • receptor binding
    		•  0.11089495579447 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle