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View Structure Prediction Details

Protein: GIT1
Organism: Homo sapiens
Length: 761 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GIT1.

Description E-value Query
Range
Subject
Range
gi|114668330 - gi|114668330|ref|XP_511377.2| PREDICTED: G protein-coupled receptor kinase interactor 1 [Pan troglod...
0.0 [1..761] [332..1101]
gi|4691726 - gi|4691726|gb|AAD28046.1|AF124490_1 ARF GTPase-activating protein GIT1 [Homo sapiens]
0.0 [1..761] [1..761]
gi|58864889 - gi|58864889|emb|CAI52038.1| G protein-coupled receptor kinase-interactor 1 [Mus musculus]
0.0 [1..761] [1..761]
gi|73967277 - gi|73967277|ref|XP_548300.2| PREDICTED: similar to G protein-coupled receptor kinase-interactor 1 [C...
0.0 [5..761] [14..779]
gi|109113899 - gi|109113899|ref|XP_001108023.1| PREDICTED: similar to G protein-coupled receptor kinase interactor ...
0.0 [17..761] [16..769]
gi|76643338 - gi|76643338|ref|XP_593042.2| PREDICTED: similar to G protein-coupled receptor kinase-interactor 1 [B...
0.0 [17..761] [52..805]
GIT1_RAT - ARF GTPase-activating protein GIT1 OS=Rattus norvegicus GN=Git1 PE=1 SV=1
0.0 [1..761] [1..770]
gi|45383548, gi|... - gi|45383548|ref|NP_989627.1| G protein-coupled receptor kinase interactor 1 [Gallus gallus], gi|1044...
0.0 [9..761] [9..740]

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Predicted Domain #1
Region A:
Residues: [1-472]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRKGPRAEV CADCSAPDPG WASISRGVLV CDECCSVHRS LGRHISIVKH LRHSAWPPTL  60
   61 LQMVHTLASN GANSIWEHSL LDPAQVQSGR RKANPQDKVH PIKSEFIRAK YQMLAFVHKL 120
  121 PCRDDDGVTA KDLSKQLHSS VRTGNLETCL RLLSLGAQAN FFHPEKGTTP LHVAAKAGQT 180
  181 LQAELLVVYG ADPGSPDVNG RTPIDYARQA GHHELAERLV ECQYELTDRL AFYLCGRKPD 240
  241 HKNGHYIIPQ MADSLDLSEL AKAAKKKLQA LSNRLFEELA MDVYDEVDRR ENDAVWLATQ 300
  301 NHSTLVTERS AVPFLPVNPE YSATRNQGRQ KLARFNAREF ATLIIDILSE AKRRQQGKSL 360
  361 SSPTDNLELS LRSQSDLDDQ HDYDSVASDE DTDQEPLRST GATRSNRARS MDSSDLSDGA 420
  421 VTLQEYLELK KALATSEAKV QQLMKVNSSL SDELRRLQRE IHKLQAENLQ LR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.522879
Match: 1n11A
Description: Ankyrin-R
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.60916417202222 bayes_pls_golite062009
protein binding 1.64872738860757 bayes_pls_golite062009
signal transducer activity 1.2375987667709 bayes_pls_golite062009
molecular transducer activity 1.2375987667709 bayes_pls_golite062009
receptor activity 1.22857731988464 bayes_pls_golite062009
transmembrane receptor activity 1.10325771560525 bayes_pls_golite062009
cytoskeletal protein binding 0.708360875374323 bayes_pls_golite062009
transcription regulator activity 0.589753112911856 bayes_pls_golite062009
peptide binding 0.215454111067296 bayes_pls_golite062009
nucleic acid binding 0.156667528524505 bayes_pls_golite062009
DNA binding 0.139886855398905 bayes_pls_golite062009
transcription factor binding 0.11440400380364 bayes_pls_golite062009
receptor binding 0.11089495579447 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [473-639]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPPGPVPTPP LPSERAEHTP MAPGGSTHRR DRQAFSMYEP GSALKPFGGP PGDELTTRLQ  60
   61 PFHSTELEDD AIYSVHVPAG LYRIRKGVSA SAVPFTPSSP LLSCSQEGSR HTSKLSRHGS 120
  121 GADSDYENTQ SGDPLLGLEG KRFLELGKEE DFHPELESLD GDLDPGL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [640-761]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSTEDVILKT EQVTKNIQEL LRAAQEFKHD SFVPCSEKIH LAVTEMASLF PKRPALEPVR  60
   61 SSLRLLNASA YRLQSECRKT VPPEPGAPVD FQLLTQQVIQ CAYDIAKAAK QLVTITTREK 120
  121 KQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.07
Match: 1k04A
Description: FAT domain of focal adhesion kinase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle