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Protein Overview: gcy-36

General Information:
Name(s) found: gcy-36 / CE39007 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00001556 locus:gcy-36 Soluble guanylate cyclase gcy-36 status:Confirmed UniProt:Q6DNF4 protein_id:CAD56232.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 675 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [ISSLink to PubMed article]
    Biological Process: cGMP biosynthetic process [IEALink to PubMed article]
    feeding behavior [IMP]
    cyclic nucleotide biosynthetic process [IEALink to PubMed article]
    Molecular Function: phosphorus-oxygen lyase activity [IEALink to PubMed article]
    guanylate cyclase activity [IEALink to PubMed article][ISSLink to PubMed article]
    heme binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFGFIHESIR QLMIRTYGEA FWSKVLERAG FEAGKENIIN HYYSDADTFS LVDAVSVILK  60
   61 VTREQVWEMY GCFLIQYTME TGWDDLIRSM SPNLKGFLDN LDSLHYFIDH VVYKANLRGP 120
  121 SFRCEDNPDG TITLHYYTGR PGLYPIVKGV LREAAKRVFK LDVSMTITGR TQRSVQMATG 180
  181 ERIEEHVIFL VKTLNTDQSN EEALGTAVVQ HSNNYKIRLT HMDFISTFPY HMVVDQDCKI 240
  241 VQVGRELYNH IPKDLLSVGT PLMRIFEVTR PQIPLDFDSI CNFINAVFVL QVKTTPMEFQ 300
  301 RNANKRAAQA IEASENLYED NNGALALSQS QHLKLKGQMM LMSSGGHIMY LCSPYVTSIP 360
  361 ELLQYGLRLT AMPIHDPTRD LILLNQQRLS DVEMNLQLEA NNEQLENMAK DLEVEKGKTD 420
  421 ALLREMLPPS VAQQLKQGLS VEAREYEEAT VMFTDVPTFQ QIVPLCTPKD IVHLLNELFT 480
  481 KFDRLIGIQK AYKVETVGDS YMSVGGIPDL VDDHCEVICH LALGMVMEAR TVCDPITNTP 540
  541 LHIRAGIHSG PVVAGVVGAK MPRYCLFGDT VNTSSRMESH SPIGRIHCSE NAKKCAESTG 600
  601 RFEFEPRGRV QIKGKGEMNT YFLLRSFKRS IWEIIDRRRD ENCNSIDGYN ELREGYVDDV 660
  661 LNKVTQKNSK TCSIS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..113] PSI-BLAST 43.09691 No description for 2o09A was found.
    2 View Details [114..406] PSI-BLAST 7.0 Musk tyrosine kinase
    3 View Details [407..675] PSI-BLAST 49.522879 Crystal structure of a mutant form of the mycobacterial adenylyl cyclase Rv1625c

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • guanylate cyclase activity
    		•  5.52874578464122 bayes_pls_golite062009
  • cyclase activity
    		•  4.4495441728539 bayes_pls_golite062009
  • phosphorus-oxygen lyase activity
    		•  4.17797478360781 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  3.27819936906601 bayes_pls_golite062009
  • kinase activity
    		•  3.03163710008327 bayes_pls_golite062009
  • protein kinase activity
    		•  2.8660447961069 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.74029785568283 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  2.59466621605752 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • binding
    		•  2.10874590528357 bayes_pls_golite062009
  • transferase activity
    		•  1.80001061545783 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.01447477827105 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.01441566554376 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.0012255632847 bayes_pls_golite062009
  • nucleotide binding
    		•  0.989402689682387 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  0.734194601335452 bayes_pls_golite062009
  • ATP binding
    		•  0.59909499260393 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.574651252033402 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.553738346856309 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.369966838509407 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.289778841954859 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.269647063625821 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.264291916981806 bayes_pls_golite062009
  • DNA binding
    		•  0.210479525543021 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle