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Protein Overview: FOXE3_RAT, FXE3_RAT

General Information:
Name(s) found: FXE3_RAT [Swiss-Prot]
FOXE3_RAT [Swiss-Prot]
Description(s) found:
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  • gi|310163|gb|AAA41323.1| HNF-3/fork-head homolog-7 [NCBI NR]
  • gi|2494499|sp|Q63250.1|FOXE3_RAT RecName: Full=Forkhead box protein E3; AltName: Full=Forkhead-related protein FKHL12; AltName: Full=Forkhead-related transcription factor 8; Short=FREAC-8; AltName: Full=Hepatocyte nuclear factor 3 forkhead homolog 7; Shor [NCBI NR]
  • pir||I60921 HNF-3/fork-head homolog-7 - rat (fragment) [NCBI NR]
  • (Q63250) Forkhead box protein E3 (Forkhead-related protein FKHL12) (Forkhead-related transcription factor 8) (FREAC-8) (Hepatocyte nuclear factor 3 forkhead homolog 7) (HFH-7) (Fragment) [Swiss-Prot]
  • Forkhead box protein E3 (Fragment) OS=Rattus norvegicus GN=Foxe3 PE=4 SV=1 [Swiss-Prot]
  • HNF-3/fork-head homolog-7 - rat (fragment)gi|2494499|sp|Q63250|FXE3_RAT FORKHEAD BOX PROTEIN E3 (FORKHEAD-RELATED PROTEIN FKHL12) (FORKHEAD-RELATED TRANSCRIPTION FACTOR 8) (FREAC-8) (HEPATOCYTE NUCLEAR FACTOR 3 FORKHEAD HOMOLOG 7) (HFH-7)gi|310163|gb|AA [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Forkhead box protein E3 [EBI-IPI_rat_3.05_04-04-2005_origrev.fasta]
  • Forkhead box protein E3 (Forkhead-related protein FKHL12) (Forkhead-related transcription factor 8) (FREAC-8) (Hepatocyte nuclear factor 3 forkhead homolog 7) (HFH-7) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • HNF-3/fork-head homolog-7 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Forkhead box protein E3 (Fragment) OS=Rattus norvegicus GN=Foxe3 [011711_HMR.fasta]
  • Forkhead box protein E3 (Fragment) OS=Rattus norvegicus GN=Foxe3 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 101 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    transcription factor complex [UNKNOWN][IEA]
    cellular_component [ND]
    Biological Process: biological_process [ND]
    eye development [UNKNOWN][IEA][IMP]
    transcription [IEA]
    regulation of transcription, DNA-dependent [IEA]
    transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    cell development [UNKNOWN][IEA][IMP]
    regulation of transcription [IEA]
    positive regulation of epithelial cell proliferation [UNKNOWN][IEA][IMP]
    Molecular Function: DNA binding [IEA]
    transcription factor activity [UNKNOWN][NAS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGKPPYSYIA LIAMALAHAP GRRLTLAAIY RFITERFAFY RDSPRKWQNS IRHNLTLNDC  60
   61 FVKVPREPGN PGKGNYWTLD PAAADMFDNG SFLRRRKRFK R

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..101] PSI-BLAST 39.221849 Genesis

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  5.08959163553491 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.99681957904233 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.85678231380989 bayes_pls_golite062009
  • transcription activator activity
    		•  3.70589483230587 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.58179858678904 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.60738445921725 bayes_pls_golite062009
  • protein binding
    		•  1.80415286835431 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.2723726467408 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.96257232341735 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.66743181561551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.322180400748724 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.23177057841536 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.56

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle