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Protein Overview: D2R-PD

General Information:
Name(s) found: D2R-PD / FBpp0099565 [FlyBase]
Description(s) found:
Found 17 descriptions.
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  • The gene Dopamine 2-like receptor is referred to in FlyBase by the symbol Dmel\D2R (CG33517, FBgn0053517). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19898715..19922226. It has the cytological map location 19A4. There is experimental evidence that it has the molecular function</span>: dopamine receptor activity, coupled via Gi/Go; dopamine receptor activity. There is experimental evidence that it is involved in the biological process</span>: dopamine receptor signaling pathway. 4 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 506 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [ISS][NAS]
    Biological Process: G-protein coupled receptor protein signaling pathway [ISS]
    dopamine receptor signaling pathway [IDA][ISS]
    Molecular Function: dopamine receptor activity [IDA][ISS]
    G-protein coupled receptor activity [ISS]
    dopamine receptor activity, coupled via Gi/Go [IDA][NAS]
    G-protein coupled amine receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLLENFNDY FPNYNGSTVS GTSTIAPGVA ITGSRGSGLL LEQNLTGLYL DGYRLNCTNE  60
   61 TLNLTDSCGE LRVVDHNYWA LILILFPILT LFGNILVILS VCRERSLQTV TNYFIVSLAI 120
  121 ADLLVAVVVM PFAVYFLVNG AWALPDVVCD FYIAMDVICS TSSIFNLVAI SIDRYIAVTQ 180
  181 PIKYAKHKNS RRVCLTILLV WAISAAIGSP IVLGLNNTPN REPDVCAFYN ADFILYSSLS 240
  241 SFYIPCIIMV FLYWNIFKAL RSRARKQRAA RKPHLSELTG GSVIENIAQT RRLAETALDS 300
  301 SRHASRILPD EAATNTASGS NEEEDENAIS PDIDDCHVIV NDKSTEFMLA TVVEETGNVA 360
  361 MKPLSFVRYG VQEAMTLARN DSTLSTTSKT SSRKDKKNSQ ASRFTIYKVH KASKKKREKS 420
  421 SAKKERKATK TLAIVLGVFL FCWLPFFSCN IMDAMCAKFK KDCRPGLTAY MMTTWLGYIN 480
  481 SFVNPVIYTI FNPEFRKAFK KIMHMG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..340] PSI-BLAST 38.522879 Rhodopsin
    2 View Details [341..506] FFAS03 5.83 Rhodopsin


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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