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Protein Overview: nhr-41

General Information:
Name(s) found: nhr-41 / CE37054 [WormBase]
Description(s) found:
Found 14 descriptions.
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  • WBGene00022423 locus:nhr-41 status:Partially_confirmed UniProt:Q3V5L2 protein_id:CCD63480.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 657 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: regulation of transcription, DNA-dependent [IEALink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    steroid hormone receptor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]
    steroid binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYTLPKCSDH PHRPLILENS TSSTGLIFAE SQASASHQTW INMTLGDPCS VEQPPPPPID  60
   61 FSRSLIAPTA IKQESHLIPS TPGTPTAFQP PQHANTPIPG IQPNLFNPAI MAAQLNVFSN 120
  121 PQLMAMMQAT RNPLLGHPSV VGPPMMPNII QQLNALRNVQ LSNANTMANL QNMSSSPKHT 180
  181 NGSSERSENC GELCVVCGDK ASGRHYGAVS CEGCKGFFKR SIRKRIGYVC RSQKDCPVTK 240
  241 FHRNRCQYCR LRKCLSMGMR SESVQAERRP VNNSSMLCNN DNNQQNTTPE HLSPNLLLSL 300
  301 VKLEHETKLG GLEALIKPGS PVMLQNTQDY MDVKRESIGE DEMTVIGLVP PSASPTSSGV 360
  361 GSSSSISDDS GPIYTSERAR FEISVPLNTQ NPRNHQYISE ITTRLLFLTV HFVKDSRVSL 420
  421 RTSTMEGLLK SKWCDLYILA LMQTADKIKL GQLLDNLTNQ MAMGMECGQY SAEKFEKISE 480
  481 QMQRLLQLSQ LFASRELTAV EYAYLKMISF TAQDLPSSMA SPETRSVNQM ASQELFEYVS 540
  541 SSKSTQNHMS NEHINVDDST SEDNDTHVTS QQSSVNIAAE RFSRILQLLP CLRWFDPATI 600
  601 VEIFFSGLIG PMSIETIIPF VLQMNLMSFF DQKMELGSGG ASDTLSTSSL SEMMNNQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] MSA 11.349997 View MSA. No confident structure predictions are available.
    2 View Details [186..276] PSI-BLAST 29.09691 Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
    3 View Details [277..577] PSI-BLAST 38.39794 Thyroid hormone receptor beta (TR-beta)
    4 View Details [578..657] PSI-BLAST 56.69897 Crystal structure of estrogen receptor beta complexed with 1-chloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.53061626347066 bayes_pls_golite062009
  • DNA binding
    		•  4.92165988569962 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.78024150262074 bayes_pls_golite062009
  • transcription activator activity
    		•  4.53302455129434 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  4.11614358606713 bayes_pls_golite062009
  • transcription factor activity
    		•  4.0914094580319 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  3.89763470197726 bayes_pls_golite062009
  • binding
    		•  3.85318710398432 bayes_pls_golite062009
  • protein binding
    		•  3.21524787168952 bayes_pls_golite062009
  • transcription factor binding
    		•  2.68044489404568 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38308182853979 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  2.30195937604451 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.20686235000733 bayes_pls_golite062009
  • receptor activity
    		•  2.07573173722434 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.73827483890179 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  1.60419100774741 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.34794228300778 bayes_pls_golite062009
  • retinoic acid receptor binding
    		•  1.28118886948947 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.23834725221597 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.19872119297817 bayes_pls_golite062009
  • signal transducer activity
    		•  1.19872119297817 bayes_pls_golite062009
  • retinoid X receptor binding
    		•  0.99801784942981 bayes_pls_golite062009
  • retinoic acid receptor activity
    		•  0.853869057774515 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.797229273848179 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.74373733735458 bayes_pls_golite062009
  • promoter binding
    		•  0.58091332905515 bayes_pls_golite062009
  • protein N-terminus binding
    		•  0.57701453824007 bayes_pls_golite062009
  • thyroid hormone receptor activity
    		•  0.49784404390361 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.45265806678057 bayes_pls_golite062009
  • receptor binding
    		•  0.418843034756825 bayes_pls_golite062009
  • ligand-regulated transcription factor activity
    		•  0.202197503742221 bayes_pls_golite062009
  • lipid binding
    		•  0.164046651023989 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.15737167800277 bayes_pls_golite062009
  • catalytic activity
    		•  0.106902059021677 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.62

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle