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Protein Overview: HSDD3_ARATH

General Information:
Name(s) found: HSDD3_ARATH [Swiss-Prot]
Description(s) found:
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  • gi|26450922|dbj|BAC42568.1| putative sterol dehydrogenase [Arabidopsis thaliana] [NCBI NR]
  • gi|229890389|sp|A9X4U2.2|HSDD3_ARATH RecName: Full=3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 3; Short=At3BETAHSD/D3; AltName: Full=Sterol-4-alpha-carboxylate 3-dehydrogenase 3, decarboxylating; AltName: Full=4alpha-carboxysterol-C3-dehydrog [NCBI NR]
  • gi|20196859|gb|AAB64337.2| putative sterol dehydrogenase [Arabidopsis thaliana] [NCBI NR]
  • gi|18406234|ref|NP_565998.1| 3-beta hydroxysteroid dehydrogenase/isomerase family protein [Arabidopsis thaliana] [NCBI NR]
  • gi|15027969|gb|AAK76515.1| putative sterol dehydrogenase [Arabidopsis thaliana] [NCBI NR]
  • 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 3 OS=Arabidopsis thaliana GN=3BETAHSD/D3 PE=2 SV=2 [Swiss-Prot]
  • (O22856) Putative sterol dehydrogenase [athaliana3702.FASTAC.txt]
  • putative sterol dehydrogenase [Arabidopsis thaliana]gi|26450922|dbj|BAC42568.1| putative sterol dehydrogenase [Arabidopsis thaliana]gi|20196859|gb|AAB64337.2| putative sterol dehydrogenase [Arabidopsis thaliana]gi|18406234|ref|NP_565998.1| 3-beta hydro [nrdb_11152004_Chlamydomonas]
  • Tax_Id=3702 3-beta hydroxysteroid dehydrogenase/isomerase family protein [EBI-IPI_Arabidopsis_3.11_12-06-2005_reversed.fasta]
  • | Symbols: | 3-beta hydroxysteroid dehydrogenase/isomerase family protein | chr2:18038570-18042013 REVERSE [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • putative sterol dehydrogenase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • 3-beta-hydroxy-delta5-steroid dehydrogenase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • | Symbols: | 3-beta hydroxysteroid dehydrogenase/isomerase family protein | chr2:18031493-18034936 REVERSE LENGTH=561 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
    • Organism: Arabidopsis thaliana
    Length: 561 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDA]
    Biological Process: metabolic process [IEA]
    steroid biosynthetic process [IEA][ISS]
    Molecular Function: 3-beta-hydroxy-delta5-steroid dehydrogenase activity [IEA][ISS]
    catalytic activity [IEA]
    binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEDSVHGDS HLKTCVVLGG RGFIGRSLVS RLLRLGNWTV RVADSGHTLH LDESDSLLED  60
   61 ALSSGRASYH CVDVRDKPQI VKVTEGSYVV FYMGATDLRS HDYFDCYKVI VQGTRNVISA 120
  121 CRESGVRKLI YNSTADVVFD GSQPIRDGDE SLRRPLKFQS MLTDFKAQAE ALIKLANNRD 180
  181 GLLTCALRSS IVFGPGDTEF VPFLVNLAKS GYAKFILGSG ENISDFTYSE NVSHAHICAV 240
  241 KALDSQMEFV AGKEFFITNL KPVRFWDFVS HIVEGLGYPR PSIKLPVRLV LYVFSLLKWT 300
  301 HEKEGLGSNY DTAHQYALLA SSTRTFNCNA AKKHLGYTPV VTLEDGIAST LQWFSRDLEK 360
  361 SDDTIIQSTA DQLLGCGKVA DILLWRNEKK TFVSFLVLNL FYYWFFFSGN TFTSSAAQLL 420
  421 FIFAVALYGV SFVPSKIFGF QVNKIPPWRF EISESAVRDL SSDIVVVWNQ GVRSFKSLSS 480
  481 GGDWIKFFKI AGSLYLLKLI VSRSLAAFLF TVMSFSFTGF FIYEQYELEL YHLARIFVEC 540
  541 LTFIKRMVIP VSDASSKPMF M

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..375] PSI-BLAST 65.39794 dTDP-glucose 4,6-dehydratase (RmlB)
    2 View Details [376..561] PSI-BLAST 13.045757 No description for 2g31A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • steroid dehydrogenase activity
    		•  3.70115036051018 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  3.56748749904419 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • receptor activity
    		•  1.59521607141455 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.57495858691649 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • signal transducer activity
    		•  1.28375985874563 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.28375985874563 bayes_pls_golite062009
  • C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
    		•  1.03845584151228 bayes_pls_golite062009
  • 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
    		•  0.744959961067911 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.65743456407889 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.648902636946461 bayes_pls_golite062009
  • binding
    		•  0.553666136934364 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  0.48941662111046 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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