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Protein Overview: DLDH1_ARATH

General Information:
Name(s) found: DLDH1_ARATH [Swiss-Prot]
Description(s) found:
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  • gi|75264759|sp|Q9M5K3.2|DLDH1_ARATH RecName: Full=Dihydrolipoyl dehydrogenase 1, mitochondrial; AltName: Full=Dihydrolipoamide dehydrogenase 1; AltName: Full=Pyruvate dehydrogenase complex E3 subunit 1; Short=PDC-E3 1; Short=E3-1; AltName: Full=Glycine cl [NCBI NR]
  • gi|30694221|ref|NP_849782.1| mtLPD1 (mitochondrial lipoamide dehydrogenase 1); ATP binding / dihydrolipoyl dehydrogenase [Arabidopsis thaliana] [NCBI NR]
  • gi|15221044|ref|NP_175237.1| mtLPD1 (mitochondrial lipoamide dehydrogenase 1); ATP binding / dihydrolipoyl dehydrogenase [Arabidopsis thaliana] [NCBI NR]
  • gi|12704696|gb|AAF34795.3|AF228639_1 lipoamide dehydrogenase precursor [Arabidopsis thaliana] [NCBI NR]
  • gi|12323085|gb|AAG51522.1|AC051631_2 lipoamide dehydrogenase, putative; 44693-46402 [Arabidopsis thaliana] [NCBI NR]
  • Dihydrolipoyl dehydrogenase 1, mitochondrial OS=Arabidopsis thaliana GN=LPD1 PE=1 SV=2 [Swiss-Prot]
  • (Q9M5K3) Lipoamide dehydrogenase [athaliana3702.FASTAC.txt]
  • lipoamide dehydrogenase precursor [Arabidopsis thaliana]gi|12323085|gb|AAG51522.1| lipoamide dehydrogenase, putative; 44693-46402 [Arabidopsis thaliana]gi|15221044|ref|NP_175237.1| dihydrolipoamide dehydrogenase 1, mitochondrial / lipoamide dehydrogenas [nrdb_11152004_Chlamydomonas]
  • Tax_Id=3702 Dihydrolipoamide dehydrogenase 1, mitochondrial [EBI-IPI_Arabidopsis_3.11_12-06-2005_reversed.fasta]
  • | Symbols: MTLPD1 | dihydrolipoamide dehydrogenase 1, mitochondrial / lipoamide dehydrogenase 1 (MTLPD1) | chr1:17721101-17722810 REVERSE [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • lipoamide dehydrogenase, putative; 44693-46402 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • lipoamide dehydrogenase precursor [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • dihydrolipoyl dehydrogenase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • | Symbols: mtLPD1 | mitochondrial lipoamide dehydrogenase 1 | chr1:17717432-17719141 REVERSE LENGTH=507 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
    • Organism: Arabidopsis thaliana
    Length: 507 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial respiratory chain complex I [IDA]
    mitochondrial matrix [ISS]
    mitochondrion [IDA]
    apoplast [IDA]
    Biological Process: response to cadmium ion [IDA][IEP]
    response to light stimulus [IEP]
    Molecular Function: ATP binding [IDA]
    zinc ion binding [IDA]
    copper ion binding [IDA]
    dihydrolipoyl dehydrogenase activity [ISS]
    cobalt ion binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMASLARRK AYFLTRNLSN SPTDALRFSF SLSRGFASSG SDENDVVIIG GGPGGYVAAI  60
   61 KASQLGLKTT CIEKRGALGG TCLNVGCIPS KALLHSSHMY HEAKHSFANH GIKVSSVEVD 120
  121 LPAMLAQKDN AVKNLTRGIE GLFKKNKVTY VKGYGKFISP NEVSVETIDG GNTIVKGKHI 180
  181 IVATGSDVKS LPGITIDEKK IVSSTGALSL SEVPKKLIVI GAGYIGLEMG SVWGRLGSEV 240
  241 TVVEFAGDIV PSMDGEIRKQ FQRSLEKQKM KFMLKTKVVS VDSSSDGVKL TVEPAEGGEQ 300
  301 SILEADVVLV SAGRTPFTSG LDLEKIGVET DKAGRILVND RFLSNVPGVY AIGDVIPGPM 360
  361 LAHKAEEDGV ACVEFIAGKH GHVDYDKVPG VVYTHPEVAS VGKTEEQLKK EGVSYRVGKF 420
  421 PFMANSRAKA IDNAEGLVKI LADKETDKIL GVHIMAPNAG ELIHEAVLAI NYDASSEDIA 480
  481 RVCHAHPTMS EALKEAAMAT YDKPIHI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..507] PSI-BLAST 112.0 Dihydrolipoamide dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  8.07008457237017 bayes_pls_golite062009
  • lipoamide binding
    		•  7.21320397413054 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  6.59152030973708 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  6.56425883527182 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  6.2758493127081 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  6.2758493127081 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  6.01050580930819 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  5.38255966064925 bayes_pls_golite062009
  • oxoglutarate dehydrogenase (succinyl-transferring) activity
    		•  5.32373368820399 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  5.18991258719053 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  3.68406278988218 bayes_pls_golite062009
  • thioredoxin-disulfide reductase activity
    		•  3.42654162439464 bayes_pls_golite062009
  • antioxidant activity
    		•  3.37477730756688 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors
    		•  3.35142373392777 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.19495080984613 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  3.17769237742078 bayes_pls_golite062009
  • oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
    		•  3.15456908604913 bayes_pls_golite062009
  • glutathione binding
    		•  2.84679371365652 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.57282017498189 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  2.50603438449246 bayes_pls_golite062009
  • oxidoreductase activity, oxidizing metal ions
    		•  2.49798084628282 bayes_pls_golite062009
  • tubulin binding
    		•  2.40546880499445 bayes_pls_golite062009
  • microtubule binding
    		•  2.30064869971937 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.28982462439281 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.23446140524739 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.12515648558024 bayes_pls_golite062009
  • catalytic activity
    		•  1.56773888754354 bayes_pls_golite062009
  • oxygen-dependent protoporphyrinogen oxidase activity
    		•  1.42994468012845 bayes_pls_golite062009
  • binding
    		•  1.4227698123368 bayes_pls_golite062009
  • protein binding
    		•  1.16738144711505 bayes_pls_golite062009
  • transporter activity
    		•  0.890824576391732 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.706117386114413 bayes_pls_golite062009
  • NADPH-adrenodoxin reductase activity
    		•  0.684108511779641 bayes_pls_golite062009
  • transferase activity
    		•  0.565295320107724 bayes_pls_golite062009
  • electron carrier activity
    		•  0.511623955786613 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.491481205015383 bayes_pls_golite062009
  • coenzyme binding
    		•  0.424849261981 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.26114823844682 bayes_pls_golite062009
  • succinate dehydrogenase activity
    		•  0.110826254138262 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  0.0160065137614933 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle