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Protein Overview: nas-14

General Information:
Name(s) found: nas-14 / CE35854 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00003533 locus:nas-14 Zinc metalloproteinase nas-14 status:Partially_confirmed UniProt:Q19269 protein_id:CAA98057.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 503 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: proteolysis [IEALink to PubMed article]
    Molecular Function: meprin A activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    astacin activity [IEALink to PubMed article]
    metallopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLLYSLFHC SAFLVGFTLS VGVLPIPNEH AASIKAKFDD YAEHYLLPED FHNAETAPVK  60
   61 KPTDAEIESM QNSLLFEGDI MGVPEIEKSD ILKRLRDDPL LDEDEIFRKP FHSALNLVTY 120
  121 PDKLWPEGQV PYMLEEGMTN DQRTAIAQAF DEYKTKTCVR FVPKTDDDFD YIYVKRNVAF 180
  181 GCSSYVGRAG GNQTVSLEVD KCFSKGIIAH ELMHALGFFH EHSRTDRDDF VDINEDNIRP 240
  241 GMMRNFEKYP RKIIDSLGMP YDYESVMHYH KLAFSRNGKP TIIPKDNEAD VGQRYKLSEM 300
  301 DSKKVNKLYQ CGEYSKTSST TTTTTTTTTT TTTEEPTTTT EVEEKPKDKK VSSTTTTTKK 360
  361 PTTTTTTTPK PVERSRNKKC EDLNAHCGMW EQLGHCQHSV KYMAHYCRKA CNLCEVEVTT 420
  421 TTTTTPKPVP RNKEKENKSA SSTTRGTSTA TSTTPKTTTT TTSAPKEKCE DKNLFCSYWA 480
  481 KIGECNSESK FMKIFCKASC GKC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] deduced N/A No confident structure predictions are available.
    2 View Details [81..264] PSI-BLAST 43.30103 STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
    3 View Details [265..503] PSI-BLAST 5.522879 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • hydrolase activity
    		•  0.768926766837908 bayes_pls_golite062009
  • peptidase activity
    		•  0.551595728198696 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.378812143092016 bayes_pls_golite062009
  • metallopeptidase activity
    		•  0.297506457480643 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  0.985811179975447 bayes_pls_golite062009
  • protein binding
    		•  0.863427243210333 bayes_pls_golite062009
  • receptor binding
    		•  0.51533753185579 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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