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View Structure Prediction Details

Protein: nas-14
Organism: Caenorhabditis elegans
Length: 503 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nas-14.

Description E-value Query
Range
Subject
Range
gi|39587709, gi|... - gi|39587709|emb|CAE58647.1| Hypothetical protein CBG01815 [Caenorhabditis briggsae], gi|187037905|em...
gi|157757555 - gi|157757555|ref|XP_001671121.1| Hypothetical protein CBG01815 [Caenorhabditis briggsae AF16]
293.0 [0..1] [503..1]

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Predicted Domain #1
Region A:
Residues: [1-80]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLLYSLFHC SAFLVGFTLS VGVLPIPNEH AASIKAKFDD YAEHYLLPED FHNAETAPVK  60
   61 KPTDAEIESM QNSLLFEGDI 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [81-264]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVPEIEKSD ILKRLRDDPL LDEDEIFRKP FHSALNLVTY PDKLWPEGQV PYMLEEGMTN  60
   61 DQRTAIAQAF DEYKTKTCVR FVPKTDDDFD YIYVKRNVAF GCSSYVGRAG GNQTVSLEVD 120
  121 KCFSKGIIAH ELMHALGFFH EHSRTDRDDF VDINEDNIRP GMMRNFEKYP RKIIDSLGMP 180
  181 YDYE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.30103
Match: 1astA
Description: STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 0.768926766837908 bayes_pls_golite062009
peptidase activity 0.551595728198696 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.378812143092016 bayes_pls_golite062009
metallopeptidase activity 0.297506457480643 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [265-503]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVMHYHKLAF SRNGKPTIIP KDNEADVGQR YKLSEMDSKK VNKLYQCGEY SKTSSTTTTT  60
   61 TTTTTTTTTE EPTTTTEVEE KPKDKKVSST TTTTKKPTTT TTTTPKPVER SRNKKCEDLN 120
  121 AHCGMWEQLG HCQHSVKYMA HYCRKACNLC EVEVTTTTTT TPKPVPRNKE KENKSASSTT 180
  181 RGTSTATSTT PKTTTTTTSA PKEKCEDKNL FCSYWAKIGE CNSESKFMKI FCKASCGKC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.985811179975447 bayes_pls_golite062009
protein binding 0.863427243210333 bayes_pls_golite062009
receptor binding 0.51533753185579 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle