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Protein Overview: CE35373

General Information:
Name(s) found: CE35373 [WormBase]
Description(s) found:
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  • WBGene00022874 locus:nep-25 status:Partially_confirmed UniProt:Q23427 protein_id:CCD72504.1 [WormBase]
  • gi|71998588|ref|NP_495164.2| hypothetical protein ZK1248.1 [Caenorhabditis elegans] [NCBI NR]
  • gi|33621046|gb|AAC71099.2| Hypothetical protein ZK1248.1 [Caenorhabditis elegans] [NCBI NR]
  • [wormpep111.fasta]
  • Hypothetical protein ZK1248.1 [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE35373 WBGene00022874 status:Partially_confirmed TR:Q23427 protein_id:AAC71099.2 [wormpep150.fasta]
  • 35373 WBGene00022874 status:Partially_confirmed TR:Q23427 protein_id:AAC71099.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • status:Partially_confirmed TR:Q23427 protein_id:AAC71099.2 [wormpep115.fasta.reversed]
  • CE35373 WBGene00022874 status:Partially_confirmed UniProt:Q23427_CAEEL protein_id:AAC71099.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE35373 WBGene00022874 status:Partially_confirmed UniProt:Q23427_CAEEL protein_id:AAC71099.2| [wormORF-contam.fasta]
  • ZK1248.1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE35373 WBGene00022874 status:Partially_confirmed UniProt:Q23427 protein_id:AAC71099.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • CE35373 WBGene00022874 locus:nep-25 status:Partially_confirmed UniProt:Q23427 protein_id:CCD72504.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • NEPrilysin metallopeptidase family OS=Caenorhabditis elegans GN=nep-25 PE=4 SV=3 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 515 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: proteolysis [IEALink to PubMed article]
    Molecular Function: zinc ion binding [IEALink to PubMed article]
    neprilysin activity [IEALink to PubMed article]
    metallopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKALLPFFIF SVFILFCTSK ASLPKNIIQE HIKKHADFSV DPCVDFYAHV CPWKVERYFM  60
   61 EDLSKLKAGM VAKYRKKHPK FDKFKGEDAF AIAEALKQLN IEQLKSECKP SKPRLSSFFI 120
  121 SAQDNRTIEN VDEVLFPGFE NYPCEEKAAI IIKEVGEIED YTTTRSVLVS AVNGFITSKL 180
  181 VEKLDVKARK LFNKFKSVIS KEIIKTPWAK NYKAIEQYVE ALSNITFRTF ADVRITVKKS 240
  241 MELYESTEKD CRKKLDVAFS QPTAELVCKG VATRKAEELL DEPIEDIFPQ DQAGILKDVW 300
  301 QMFNSFDNSV YIGNEFLLLL NTDYFSDLYG SIGFSMIHEI MHTLVFDDND LDKPLSKLWT 360
  361 KNADCVKDQA LKTCETFPTV TEMHNMKPAC NTTVTFEEDA ADLAAYRIAW RIYENSYARK 420
  421 TVVPNYEALD KKQLFFYGAA VFFCNQDGMS RVPFQNLAHS NNYQRVNSLM SQMKQFSDAF 480
  481 KCKPTDKMIT NRAKHCELYG SGSPMTRKKN AGNYY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..515] PSI-BLAST 110.0 Neutral endopeptidase (neprilysin)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  0.361128926739778 bayes_pls_golite062009
  • hydrolase activity
    		•  0.29183147920977 bayes_pls_golite062009
  • peptidase activity
    		•  0.23695590197447 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.0341081586881899 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle