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Protein Overview: mec-3

General Information:
Name(s) found: mec-3 / CE34792 [WormBase]
Description(s) found:
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  • WBGene00003167 locus:mec-3 Mechanosensory protein 3 status:Partially_confirmed UniProt:P09088 protein_id:CAE17755.1 [WormBase]
  • gi|71985881|ref|NP_001023112.1| MEChanosensory abnormality family member (mec-3) [Caenorhabditis elegans] [NCBI NR]
  • gi|33300085|emb|CAE17755.1| C. elegans protein F01D4.6b, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|156364|gb|AAA28108.1| mec-3 protein [NCBI NR]
  • [wormpep111.fasta]
  • CE34792 WBGene00003167 locus:mec-3 status:Partially_confirmed SW:P09088 protein_id:CAE17755.1 [wormpep150.fasta]
  • 34792 WBGene00003167 locus:mec-3 status:Predicted TR:Q7YTQ4 protein_id:CAE17755.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • Hypothetical protein F01D4.6b [Caenorhabditis elegans]gi|156364|gb|AAA28108.1| mec-3 protein [nrdb_11152004_Chlamydomonas]
  • CE34792 WBGene00003167 locus:mec-3 status:Predicted TR:Q7YTQ4 protein_id:CAE17755.1 [wormpep132.fasta]
  • 34792 WBGene00003167 locus:mec-3 status:Partially_confirmed SW:P09088 protein_id:CAE17755.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • CE34792 WBGene00003167 locus:mec-3 status:Partially_confirmed TR:Q7YTQ4 protein_id:CAE17755.1 [WormBase_C-elegans_na_01-20-2005_combined_reversed.fasta]
  • locus:mec-3 status:Partially_confirmed TR:Q7YTQ4 protein_id:CAE17755.1 [wormpep115.fasta.reversed]
  • CE34792 WBGene00003167 locus:mec-3 status:Partially_confirmed UniProt:P09088 protein_id:CAE17755.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE34792 WBGene00003167 locus:mec-3 status:Partially_confirmed UniProt:P09088 protein_id:CAE17755.1| [wormORF-contam.fasta]
  • Hypothetical protein F01D4.6b [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • MEChanosensory abnormality family member (mec-3) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • mec-3 protein [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • Isoform of P09088, Isoform b of Mechanosensory protein 3 OS=Caenorhabditis elegans GN=mec-3 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 313 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: mechanosensory behavior [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    neuron development [IMPLink to PubMed articleLink to PubMed article]
    response to mechanical stimulus [IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRLHDIWLL TGDLLQESSK ITASSKNSET IIYFQMDNRS YHENCVKCTI CESPLAEKCF  60
   61 WKNGRIYCSQ HYYKDHSIHR CAGCKKGVSP TDMVYKLKAG LVFHVECHCC SLCGRHLSPG 120
  121 EQILVDDTMM TVSCMSHYPP QMDDNAPGAI GSAVDIPSCS TENPIAPYPI DESFSSAFQV 180
  181 KKEVDAYGYN FEHYSFSDFC DDDSRMLKRR GPRTTIKQNQ LDVLNEMFSN TPKPSKHARA 240
  241 KLALETGLSM RVIQVWFQNR RSKERRLKHL CNYLRHYEQR GLIPPPIHFR NEEMDTTDFN 300
  301 AFCGNFEEED DED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..194] PSI-BLAST 17.69897 No description for 2dfyX was found.
    2 View Details [195..313] PSI-BLAST 11.522879 Solution structure of the homeobox domain of the human paired box protein Pax-6

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  1.04132983826241 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle