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View Structure Prediction Details

Protein: mec-3
Organism: Caenorhabditis elegans
Length: 313 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mec-3.

Description E-value Query
Range
Subject
Range
LHX9 - LIM homeobox 9
gi|109018974 - gi|109018974|ref|XP_001110636.1| PREDICTED: LIM homeobox 9 isoform 2 [Macaca mulatta]
gi|114571650 - gi|114571650|ref|XP_525011.2| PREDICTED: LIM homeobox 9 isoform 6 [Pan troglodytes]
153.0 [0..20] [310..61]

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Predicted Domain #1
Region A:
Residues: [1-194]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRLHDIWLL TGDLLQESSK ITASSKNSET IIYFQMDNRS YHENCVKCTI CESPLAEKCF  60
   61 WKNGRIYCSQ HYYKDHSIHR CAGCKKGVSP TDMVYKLKAG LVFHVECHCC SLCGRHLSPG 120
  121 EQILVDDTMM TVSCMSHYPP QMDDNAPGAI GSAVDIPSCS TENPIAPYPI DESFSSAFQV 180
  181 KKEVDAYGYN FEHY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.69897
Match: 2dfyX
Description: No description for 2dfyX was found.

Predicted Domain #2
Region A:
Residues: [195-313]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFSDFCDDDS RMLKRRGPRT TIKQNQLDVL NEMFSNTPKP SKHARAKLAL ETGLSMRVIQ  60
   61 VWFQNRRSKE RRLKHLCNYL RHYEQRGLIP PPIHFRNEEM DTTDFNAFCG NFEEEDDED

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.522879
Match: 2cueA
Description: Solution structure of the homeobox domain of the human paired box protein Pax-6
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle