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Protein Overview: nhr-105

General Information:
Name(s) found: nhr-105 / CE34659 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00003695 locus:nhr-105 status:Confirmed UniProt:Q86PJ4 protein_id:CCD83547.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 429 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: regulation of transcription, DNA-dependent [IEALink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    steroid hormone receptor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTFSDPMDPS IPIFQHHEEE EAGPSTTIKA EEEDGPCCLV CGRVANTGHH YGVTACLGCK  60
   61 TFFRRVVLQK NSPKCKYKNH CRLEKSVNAK RLCRSCRYQK CLEVGMTEDA LHPCRDVIGR 120
  121 RVRNNSSDSS PISSPPSIPT PLSICKLMNL SEGDHKLLQT ITDMDTDIRT RTAHILGEPA 180
  181 NGNEQIHFYS PTPDYTNVIV NHGIGPSLKV DILLLREWVD RIPGFRELSE RFQQHLMHRF 240
  241 CLRYTVIEHG LFTAQMPYHK NVWFLSDRTC LVSEFENLPQ EIKKHLTPKV INEQQLLASF 300
  301 TEMLIHEVAD PLRRLKPDSV EVATVKTLML LKPTCLREID GDYLSTETDI KSVNDVRNRV 360
  361 INGLYSHYIK NGMDPEQLPI RVSEILNLTG GVEQCAARAL EEMHPTRVFN LSSFDPYSSN 420
  421 VIFGYYRDV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] PSI-BLAST 18.0 No description for 2hanB was found.
    2 View Details [111..429] PSI-BLAST 32.69897 Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  2.96944106977308 bayes_pls_golite062009
  • DNA binding
    		•  2.64662954118345 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.60185057203337 bayes_pls_golite062009
  • binding
    		•  2.32420977112004 bayes_pls_golite062009
  • transcription factor activity
    		•  1.93863380769331 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.48167714708574 bayes_pls_golite062009
  • protein binding
    		•  1.39455913713025 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.71958532653437 bayes_pls_golite062009
  • transcription activator activity
    		•  0.715538962910453 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  0.613774016982502 bayes_pls_golite062009
  • transcription factor binding
    		•  0.52161600305754 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.36842807815039 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.49038190939006 bayes_pls_golite062009
  • DNA binding
    		•  3.96083427960775 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.90952833171457 bayes_pls_golite062009
  • binding
    		•  3.21329762799781 bayes_pls_golite062009
  • transcription factor activity
    		•  3.12234353900549 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  3.01625722166173 bayes_pls_golite062009
  • transcription activator activity
    		•  2.29529712113489 bayes_pls_golite062009
  • protein binding
    		•  2.16479360297106 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.10605540558576 bayes_pls_golite062009
  • receptor activity
    		•  2.07573173722434 bayes_pls_golite062009
  • transcription factor binding
    		•  1.81682309019455 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  1.46458984705588 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.4555195551904 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.33520830189299 bayes_pls_golite062009
  • signal transducer activity
    		•  1.19872119297817 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.19872119297817 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.901297393989265 bayes_pls_golite062009
  • retinoic acid receptor binding
    		•  0.520157552022887 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.4518457324832 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.36873580106364 bayes_pls_golite062009
  • retinoid X receptor binding
    		•  0.250198693036147 bayes_pls_golite062009
  • catalytic activity
    		•  0.106902059021677 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle