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View Structure Prediction Details

Protein: nhr-105
Organism: Caenorhabditis elegans
Length: 429 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-105.

Description E-value Query
Range
Subject
Range
gi|73967652 - gi|73967652|ref|XP_548399.2| PREDICTED: similar to Retinoic acid receptor RXR-alpha (Retinoid X rece...
279.0 [0..3] [423..23]

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Predicted Domain #1
Region A:
Residues: [1-110]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTFSDPMDPS IPIFQHHEEE EAGPSTTIKA EEEDGPCCLV CGRVANTGHH YGVTACLGCK  60
   61 TFFRRVVLQK NSPKCKYKNH CRLEKSVNAK RLCRSCRYQK CLEVGMTEDA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.0
Match: 2hanB
Description: No description for 2hanB was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.96944106977308 bayes_pls_golite062009
DNA binding 2.64662954118345 bayes_pls_golite062009
nucleic acid binding 2.60185057203337 bayes_pls_golite062009
binding 2.32420977112004 bayes_pls_golite062009
transcription factor activity 1.93863380769331 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.48167714708574 bayes_pls_golite062009
protein binding 1.39455913713025 bayes_pls_golite062009
sequence-specific DNA binding 0.71958532653437 bayes_pls_golite062009
transcription activator activity 0.715538962910453 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 0.613774016982502 bayes_pls_golite062009
transcription factor binding 0.52161600305754 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.36842807815039 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [111-429]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LHPCRDVIGR RVRNNSSDSS PISSPPSIPT PLSICKLMNL SEGDHKLLQT ITDMDTDIRT  60
   61 RTAHILGEPA NGNEQIHFYS PTPDYTNVIV NHGIGPSLKV DILLLREWVD RIPGFRELSE 120
  121 RFQQHLMHRF CLRYTVIEHG LFTAQMPYHK NVWFLSDRTC LVSEFENLPQ EIKKHLTPKV 180
  181 INEQQLLASF TEMLIHEVAD PLRRLKPDSV EVATVKTLML LKPTCLREID GDYLSTETDI 240
  241 KSVNDVRNRV INGLYSHYIK NGMDPEQLPI RVSEILNLTG GVEQCAARAL EEMHPTRVFN 300
  301 LSSFDPYSSN VIFGYYRDV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.69897
Match: 1xdkB
Description: Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.49038190939006 bayes_pls_golite062009
DNA binding 3.96083427960775 bayes_pls_golite062009
nucleic acid binding 3.90952833171457 bayes_pls_golite062009
binding 3.21329762799781 bayes_pls_golite062009
transcription factor activity 3.12234353900549 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 3.01625722166173 bayes_pls_golite062009
transcription activator activity 2.29529712113489 bayes_pls_golite062009
protein binding 2.16479360297106 bayes_pls_golite062009
sequence-specific DNA binding 2.10605540558576 bayes_pls_golite062009
receptor activity 2.07573173722434 bayes_pls_golite062009
transcription factor binding 1.81682309019455 bayes_pls_golite062009
steroid hormone receptor activity 1.46458984705588 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.4555195551904 bayes_pls_golite062009
transcription repressor activity 1.33520830189299 bayes_pls_golite062009
signal transducer activity 1.19872119297817 bayes_pls_golite062009
molecular transducer activity 1.19872119297817 bayes_pls_golite062009
transcription cofactor activity 0.901297393989265 bayes_pls_golite062009
retinoic acid receptor binding 0.520157552022887 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.4518457324832 bayes_pls_golite062009
transcription coactivator activity 0.36873580106364 bayes_pls_golite062009
retinoid X receptor binding 0.250198693036147 bayes_pls_golite062009
catalytic activity 0.106902059021677 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle