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Protein Overview: lig-4

General Information:
Name(s) found: lig-4 / CE34522 [WormBase]
Description(s) found:
Found 15 descriptions.
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  • WBGene00002986 locus:lig-4 status:Partially_confirmed UniProt:Q95YE6 protein_id:CCD63588.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 741 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: DNA repair [IEALink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    DNA replication [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    DNA recombination [IEALink to PubMed article]
    meiosis [IMPLink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    DNA ligase (ATP) activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASDVIFDEV VDVFNKIRRT SNVKSKQATF QKNFESWKEK CSDPSDMFVI IRFFVSDYER  60
   61 FRKFDMGPTK LASFMAKTFH DVRADYVSTI SKDASTAARQ LAEKISEEYR TENDESTVVT 120
  121 VSELNEILDF LAAGPMDDGN KRDKMSKLVK RCSEDELEWI FNVILKNVES ALGAPSNRIL 180
  181 DWISPSACAI WDQTHDLKAV LKGKLVENKG TNELGETNDD DDEHLFKIWT PMLLQKQKRG 240
  241 DWYANIEKFG GQKFFLQTKF DGENVLLHKK GNEYRWFTRN NNDFSKEYGD SSMAIGKLSS 300
  301 RIHSFFNKEC ESAIFNCELM LWDKKTKKLC RHNDASTTSD AQVLSFRHVK PDDNQQLTVV 360
  361 LFDLLYLNGK PFFGAPLHQR LEMLKIAPLK KEREDTIFVA KHEEGSKKED IQQFFEIAMA 420
  421 NNEEGIVVKR TDSVYVKGQR SASNGWFKLK PSASKDCDLD LALVAVHPGA GRNGKTLYRF 480
  481 AAFDEKTQDY KLCLSCSYGL SDTVREAIRF EYGQLLEEAP EELTFYGKRP KNIARGDGGY 540
  541 IDFERWQVIK ITSNGVRNGK LVDPVMREWR LDKPVEQVNT WEEFSDYATK VQECKLGDNV 600
  601 DSDEEDSEDK KPDTLKVERI TRKAIHQSAP VRLKRAKLES SLTGIEVAVL QGTSETIRRK 660
  661 CEEILKHFDA TVVKGITPST KLCIATAPKS THPKTAQAIA SNSCTVLKPA WLERCNKDDL 720
  721 IQAWLPSDVF HAIEGGFEIQ E

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..634] PSI-BLAST 109.0 Crystal Structure of Human DNA Ligase I bound to 5'-adenylated, nicked DNA
    2 View Details [635..741] PSI-BLAST 20.154902 No description for 2e2wA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA ligase activity
    		•  10.0279903057926 bayes_pls_golite062009
  • ligase activity, forming phosphoric ester bonds
    		•  9.92846900587219 bayes_pls_golite062009
  • DNA ligase (ATP) activity
    		•  8.51283882444113 bayes_pls_golite062009
  • DNA ligase (NAD+) activity
    		•  3.17397926295565 bayes_pls_golite062009
  • ligase activity
    		•  2.36807839237461 bayes_pls_golite062009
  • catalytic activity
    		•  2.15370807854636 bayes_pls_golite062009
  • binding
    		•  1.82998145778732 bayes_pls_golite062009
  • protein binding
    		•  1.38006517521813 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.06318697852063 bayes_pls_golite062009
  • DNA binding
    		•  0.920391596538289 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle