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Protein Overview: aph-2

General Information:
Name(s) found: aph-2 / CE34446 [WormBase]
Description(s) found:
Found 17 descriptions.
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  • WBGene00000148 locus:aph-2 Nicastrin status:Partially_confirmed UniProt:Q23316 protein_id:CAB00063.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 723 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    protein processing [IEALink to PubMed article]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKWLVIVLI IAGIRCDGFS DQVFRTLFIG EGNACYRTFN KTHEFGCQAN RENENGLIVR  60
   61 IDKQEDFKNL DSCWNSFYPK YSGKYWALLP VNLIRRDTIS QLKSSKCLSG IVLYNSGESI 120
  121 HPGDESTAAS HDAECPNAAS DYYLQDKNEE YCERKINSRG AITRDGLMKI DWRIQMVFID 180
  181 NSTDLEIIEK CYSMFNKPKE DGSSGYPYCG MSFRLANMAA GNSEICYRRG KNDAKLFQMN 240
  241 IDSGDAPQLC GAMHSDNIFA FPTPIPTSPT NETIITSKYM MVTARMDSFG MIPEISVGEV 300
  301 SVLTSIISVL AAARSMGTQI EKWQKASNTS NRNVFFAFFN GESLDYIGSG AAAYQMENGK 360
  361 FPQMIRSDRT HIHPIRPNEL DYILEVQQIG VAKGRKYYVH VDGERYQQNK TQTDRVIDRI 420
  421 ERGLRSHAFD LEKPSGSGDR VPPASWHSFA KADAHVQSVL LAPYGKEYEY QRVNSILDKN 480
  481 EWTEDEREKA IQEIEAVSTA ILAAAADYVG VETDEVVAKV DKKLITTIFD CLITSNFWFD 540
  541 CDFMQKLDGG RYHKLFNSYG FNQKSTYISM ESHTAFPTVL HWLTIFALGS DKETLNVKSE 600
  601 KSCSHLGQFQ AFQMYTYTWQ PNPYTGNFSC LKSAIVKKVM VSPAVDSQTP EEEMNTRYST 660
  661 WMESVYIIES VNLYLMEDAS FEYTMILIAV ISALLSIFAV GRCSETTFIV DEGEPAAEGG 720
  721 EPL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..134] MSA 1.03297 View MSA. No confident structure predictions are available.
    2 View Details [135..558] PSI-BLAST 31.09691 Transferrin receptor ectodomain, C-terminal domain; Transferrin receptor ectodomain, apical domain; Transferrin receptor ectodomain, protease-like domain
    3 View Details [559..723] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.76097450390625 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.68442839136734 bayes_pls_golite062009
  • receptor activity
    		•  3.43249110530054 bayes_pls_golite062009
  • hydrolase activity
    		•  2.71452093699272 bayes_pls_golite062009
  • signal transducer activity
    		•  2.61784313760368 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.61784313760368 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.16368706007937 bayes_pls_golite062009
  • catalytic activity
    		•  0.463274780485604 bayes_pls_golite062009
  • metallopeptidase activity
    		•  0.0887519845185331 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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