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Protein Overview: hrs-1

General Information:
Name(s) found: hrs-1 / CE33829 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00002001 locus:hars-1 Histidine--tRNA ligase status:Confirmed UniProt:P34183 protein_id:CAD89746.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 521 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: tRNA aminoacylation for protein translation [IEALink to PubMed article]
    histidyl-tRNA aminoacylation [IEALink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    histidine biosynthetic process [IEALink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    growth [IMPLink to PubMed article]
    translation [IEALink to PubMed article]
    Molecular Function: nucleotide binding [IEALink to PubMed article]
    histidine-tRNA ligase activity [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    aminoacyl-tRNA ligase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRTITSRLA FSVRQAEETV KPRIAYAQRS GRRIKEKVAL MQAKRKEAGE TGAPEKPGKF  60
   61 VLKTGKGTRD YGPAQSALRN SVLQTVTETF NRYGAETIDT PVFELRDVLM GKYGEEGGKL 120
  121 VYDLQDQGGE LLSLRYDLTV PFARYLAMNK ITNITRYQIA KVYRRDQPVM SRGRYREFYQ 180
  181 CDFDIAGQYD LMLPEAECLG IVDELLTKLE IGEFFINLNH RLILEGMFAV SGIPAKDFKT 240
  241 ICSSVDKLDK TPWEDVEQEM INEKFLTKEQ TGKLGELVRF RELNSDLNNL ELLEKMSQLP 300
  301 DLGQNDKFKK GAEELKVLIE YLNVDGVTTV RYEPSLARGL DYYTGAIYEA VAPKALEGTA 360
  361 VENSEDTAGQ PVGVGSVAAG GRYDGLVKMF DSKANVPCCG VSFGIERLFA IMEARQKVAI 420
  421 RTTQTEVYVA SAQKNLVRDR KKLVKMLRSA GIKTEMALKA NPKLLTQFQY AEERRIPLAI 480
  481 VIGEQELKDG VVKLRNVVTR DEQTIKLDQL ITAVRDTLAA L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..60] PSI-BLAST 14.09691 Crystal Structure of mammalian mitochondrial seryl-tRNA synthetase complexed with seryl-adenylate
    2 View Details [61..521] PSI-BLAST 81.69897 Histidyl-tRNA synthetase (HisRS), C-terminal domain; Histidyl-tRNA synthetase (HisRS)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  6.0520403280225 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  6.0520403280225 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  6.04138870254626 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  5.91343220471745 bayes_pls_golite062009
  • ligase activity
    		•  4.85905957427768 bayes_pls_golite062009
  • proline-tRNA ligase activity
    		•  3.10945929267718 bayes_pls_golite062009
  • phenylalanine-tRNA ligase activity
    		•  2.99105702052936 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  2.46505535069103 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  2.29229136935761 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  2.18642354927 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  1.82594054955281 bayes_pls_golite062009
  • lysine-tRNA ligase activity
    		•  1.72324031407565 bayes_pls_golite062009
  • binding
    		•  1.30923742450698 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  0.921492123574877 bayes_pls_golite062009
  • catalytic activity
    		•  0.902495165806215 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.375542987753806 bayes_pls_golite062009
  • protein binding
    		•  0.358563180490135 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.281662799812287 bayes_pls_golite062009
  • DNA binding
    		•  0.0309732052586011 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.00572514744734753 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle